The eastern part of Europe is very poorly represented in the Global Network for Isotopes in Precipitation (GNIP) database, mainly because the monitoring of the stable isotopes in precipitation started only recently compared with other regions. In this respect, the main objective of this article is to fill the gap in the GNIP database over the eastern part of Europe and show the temporal variability and potential drivers of an extended network of δ¹⁸O values in precipitation collected from 27 locations in Romania and the Republic of Moldova. We also present the first high-resolution map of the spatio-temporal distribution of δ¹⁸O values in precipitation in Romania and the Republic of Moldova, according to an observational dataset. According to our results, the stations from western and northern Romania tend to have LMWL_S with higher values than those from southwestern Romania. The monthly variation of the δ¹⁸O and δ²H showed a clearly interannual variation, with distinct seasonal differences, following the seasonal temperatures. The analysis of the spatial distribution of stable isotopes in precipitation water was made on the basis of both observational data and modeled data. This allowed us to study the origin of the air moisture and the interaction with regional and local patterns and to analyze the link between the spatial δ¹⁸O variations and the large-scale circulation patterns on a seasonal scale.