The design of molecular solar fuels is challenging because of the long list of requirements these molecules have to fulfil: storage density, solar harvesting capacity, robustness, and heat release ability. All of these features cause a paradoxical design due to the conflicting effects found when trying to improve any of these properties. In this contribution, we will review different types of compounds previously suggested for this application. Each of them present several advantages and disadvantages, and the scientific community is still struggling to find the ideal candidate suitable for practical applications. The most promising results have been found using norbornadiene-based systems, although the use of other alternatives like azobenzene or dihydroazulene cannot be discarded. In this review, we primarily focus on highlighting the optical and photochemical aspects of these three families, discussing the recently proposed systems and recent advances in the field.

Avobenzone is one of the most widely used sunscreens in skin care formulations, but suffers from some drawbacks, including photo instability. To mitigate this critical issue, the use of octocrylene as a stabilizer is a common approach in these products. However, octocrylene has been recently demonstrated to show potential phototoxicity. The aim of this work is to analyze the performance of a series of mycosporine-like amino acid (MAA)-inspired compounds to act as avobenzone stabilizers as an alternative to octocrylene. Different avobenzone/MAA analogue combinations included in galenic formulations were followed under increasing doses of solar-simulated UV radiation. Some of the synthetic MAA analogues analyzed were able to increase by up to two times the UV dose required for 50% of avobenzone photobleaching. We propose some of these MAA analogues as new candidates to act as avobenzone-stabilizing compounds in addition to their UV absorbance and antioxidant properties, together with a facile synthesis.

Introduction: The good results of home intravenous therapy, the greater complexity of patients and the increase in hospital pressure cause that every time the technical requirements on it are more demanding. Method: Of all drugs, a search was carried out in order using MESH terms searching: [“drug” and stability], [“drug” and storage], [“drug” and solvent]. Results: This article details the critical technical aspects when considering a home intravenous antibiotic therapy strategy: antimicrobials (antibiotics, antifungals and antivirals) candidates to be administered at home intravenously in an inpatient in charge of a home hospitalization service are reviewed: the candidate drugs, the concentration to be administered, the minimum infusion times, storage conditions, maximum stability, the most frequent compatible solvents and the vascular access in which we should administer according to the physicochemical properties of the drug, the delivery device and the expected duration of treatment. Conclusions: It is essential when considering a home antibiotic intravenous therapy that the drugs are correctly conditioned and selected. Introducción: Los buenos resultados de la terapia intravenosa domiciliaria, la mayor complejidad de los pacientes y el aumento de presión hospitalaria provocan que cada vez que los requerimientos técnicos sobre la misma sean más exigentes. Método: De todos los principios activos se realizó una búsqueda ordenada mediante términos MESH buscando: [“principio activo” and stability], [“principio activo” and storage], [“principio activo” and solvent]. Resultados: En este artículo se detallan los aspectos técnicos críticos a la hora de plantear una estrategia de antibioterapia intravenosa a domicilio: se revisan los antimicrobianos (antibióticos, antifúngicos y antivirales) candidatos a ser administrados en el domicilio por vía intravenosa en un paciente ingresado cargo de un servicio de hospitalización a domicilio: se revisan los principios activos candidatos, la concentración a la que se debe administrar, los tiempos de infusión mínimos, las condiciones de conservación, las estabilidades máximas, los solventes compatibles más frecuentes tipo de vía en la que deberíamos administrar según las propiedades fisicoquímicas del fármaco, el dispositivo de administración y la duración prevista del tratamiento. Conclusiones: Es fundamental a la hora de plantear una terapia intravenosa antibiótica domiciliaria que los fármacos se encuentren correctamente acondicionados y seleccionados.