Artificial intelligence (AI) and 3D printing will become technologies that profoundly impact humanity. 3D printing of patient-specific organ models is expected to replace animal carcasses, providing scenarios that simulate the surgical environment for preoperative training and educating patients to propose effective solutions. Due to the complexity of 3D printing manufacturing, it is still used on a small scale in clinical practice, and there are problems such as the low resolution of obtaining MRI/CT images, long consumption time, and insufficient realism. AI has been effectively used in 3D printing as a powerful problem-solving tool. This paper introduces 3D printed organ models, focusing on the idea of AI application in 3D printed manufacturing of organ models. Finally, the potential application of AI to 3D-printed organ models is discussed. Based on the synergy between AI and 3D printing that will benefit organ model manufacturing and facilitate clinical preoperative training in the medical field, the use of AI in 3D-printed organ model making is expected to become a reality.