A series of new conjugated compounds with a –SCH₂– linkage were synthesized by chemical methods from imidazole and coumarin derivatives. The experimental results indicate that of the twenty newly synthesized imidazole–coumarin conjugates, three of them exhibited appealing EC₅₀ values (5.1–8.4 μM) and selective indices >20 against hepatitis C virus. Their potency and selectivity were increased substantially by modification of their structure with two factors: imidazole nucleus with a hydrogen atom at the N(1) position and coumarin nucleus with a substituent, such as Cl, F, Br, Me, and OMe. These guidelines provide valuable information for further development of conjugated compounds as anti-viral agents.

New ways to synthesize or to utilize the nitro compounds, nitrones, nitrates, oximes, hydroxylamines, and amine oxides are described in this Account. Discussions cover the design and mechanisms of some novel reactions involving compounds bearing an N-O_x(x=1-3) moiety.