Zachary Axog Mark Valiukas

Mr. Zachary Axog Mark Valiukas


Research Focus & Metrics

Academic Career Length

5Years (2022-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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14 September 2022 in Vaccines
Verified
Journal Article
Open access
PDF file
ZVZachary Axog Mark Valiukas
Zachary Axog Mark Valiukas
RERamya Ephraim
Ramya Ephraim
KTKathy Tangalakis
Kathy Tangalakis
Majid DavidsonMajid Davidson
Majid Davidson
Vasso ApostolopoulosVasso Apostolopoulos
Vasso Apostolopoulos
Jack FeehanJack Feehan
Jack Feehan
Alzheimer’s disease (AD) is a chronic neurodegenerative disorder that falls under the umbrella of dementia and is characterised by the presence of highly neurotoxic amyloid-beta (Aβ) plaques and neurofibrillary tangles (NFTs) of tau protein within the brain. Historically, treatments for AD have consisted of medications that can slow the progression of symptoms but not halt or reverse them. The shortcomings of conventional drugs have led to a growing need for novel, effective approaches to the treatment of AD. In recent years, immunotherapies have been at the forefront of these efforts. Briefly, immunotherapies utilise the immune system of the patient to treat a condition, with common immunotherapies for AD consisting of the use of monoclonal antibodies or vaccines. Most of these treatments target the production and deposition of Aβ due to its neurotoxicity, but treatments specifically targeting tau protein are being researched as well. These treatments have had great variance in their efficacy and safety, leading to a constant need for the research and development of new safe and effective treatments.