Marine natural products (MNPs) continue to be in the spotlight in the global drug discovery endeavor. Currently, more than 30,000 structurally diverse secondary metabolites from marine sources have been isolated, making MNPs a profound, renewable source to investigate novel drug compounds. Marine sponges of the genus Suberea (family: Aplysinellidae) are recognized as producers of bromotyrosine derivatives, which are considered distinct chemotaxonomic markers for the marine sponges belonging to the order Verongida. This class of compounds exhibits structural diversity, ranging from simple monomeric molecules to more complex molecular scaffolds, displaying a myriad of biological and pharmacological potentialities. In this review, a comprehensive literature survey covering the period of 1998–2018, focusing on the chemistry and biological/pharmacological activities of marine natural products from marine sponges of the genus Suberea, with special attention to the biogenesis of the different skeletons of halogenated compounds, is presented.

Pyrroloquinoline and guanidine-derived alkaloids present distinct groups of marine secondary metabolites with structural diversity that displayed potentialities in biological research. A considerable number of these molecular architectures had been recorded from marine sponges belonging to different marine genera, including Batzella, Crambe, Monanchora, Clathria, Ptilocaulis and New Caledonian starfishes Fromia monilis and Celerina heffernani. In this review, we aim to comprehensively cover the chemodiversity and the bioactivities landmarks centered around the chemical constituents exclusively isolated from these three marine genera including Batzella, Crambe and Monanchora over the period 1981–2017, paying a special attention to the polycyclic guanidinic compounds and their proposed biomimetic landmarks. It is concluded that these marine sponge genera represent a rich source of novel compounds with potential applications for cancer and other therapeutic areas.

Phytochemical investigation of Thevetia peruviana leaves has resulted in isolation and identification of 12β-hydroxy-4,16-pregnadien-3,20-dione, using several chromatographic and spectral techniques, beside identification of thirty-seven volatile constituents of a biological interests from the pet. ether and the methylene chloride extracts using GC/MS analysis. The volatile constituents belonging to different classes, acetogenins (fat derivatives), terpenes, shikimates (phenolic constituents) and pregnanes.

Phytochemical investigation of Huernia saudi-arabica aerial parts has resulted in separation and identification of a pregnane glycoside, russelioside B, as its first report from this plant species, using chromatographic and spectroscopic techniques. Additionally, the flavonoid glycoside, luteolin 4'-O-β-D-neohesperidoside was also isolated and identified.