Low-dose X-ray computed tomography (CT) simulation from a high-dose scan is required in optimizing radiation dose to patients. In this paper, we propose a simple low-dose CT simulation strategy in the sinogram domain using the raw data from high-dose scan. Specially, a relationship between the incident fluxes of low- and high-dose scans is first determined according to the repeated projection measurements and analysis. Second, the incident flux level of the simulated low-dose scan is generated by properly scaling the incident flux level of the high-dose scan via the determined relationship in the first step. Third, the low-dose CT transmission data by energy integrating detection is simulated by adding a statistically independent Poisson noise distribution plus a statistically independent Gaussian noise distribution. Finally, a filtered back-projection (FBP) algorithm is implemented to reconstruct the resultant low-dose CT images. The present low-dose simulation strategy is verified on the simulations and real scans by comparing it with the existing low-dose CT simulation tool. Experimental results demonstrated that the present low-dose CT simulation strategy can generate accurate low-dose CT sinogram data from high-dose scans in terms of qualitative and quantitative measurements.

Conventional cone-beam computed tomography is often deteriorated by respiratory motion blur, which negatively affects target delineation. On the other side, the four dimensional cone-beam computed tomography (4D-CBCT) can be considered to describe tumor and organ motion. But for current on-board CBCT imaging system, the slow rotation speed limits the projection number at each phase, and the associated reconstructions are contaminated by noise and streak artifacts using the conventional algorithm. To address the problem, we propose a novel framework to reconstruct 4D-CBCT from the under-sampled measurements—Motion guided Spatiotemporal Sparsity (MgSS). In this algorithm, we try to divide the CBCT images at each phase into cubes (3D blocks) and track the cubes with estimated motion field vectors through phase, then apply regional spatiotemporal sparsity on the tracked cubes. Specifically, we recast the tracked cubes into four-dimensional matrix, and use the higher order singular value decomposition (HOSVD) technique to analyze the regional spatiotemporal sparsity. Subsequently, the blocky spatiotemporal sparsity is incorporated into a cost function for the image reconstruction. The phantom simulation and real patient data are used to evaluate this algorithm. Results show that the MgSS algorithm achieved improved 4D-CBCT image quality with less noise and artifacts compared to the conventional algorithms.

Dynamic CT myocardial perfusion imaging (DCT-MPI) is a reliable examination tool for the assessment of myocardium and vascular, while its special scan protocol may result in excessive radiation exposure to patients and inevitable inter-frame motion. Lowering the tube current is a simple way to reduce radiation exposure. However, low mAs will certainly cause severe image noise, thus may further impact the accuracy of functional hemodynamic parameters, which are used for the assessment of blood supply. In this work, we present a novel scheme applying motion compensation and local low rank regularization (MC-LLR) for obtaining high quality motion compensated DCT-MPI images. Specifically, motion compensation by using robust data decomposition registration (RDDR) was introduced. Robust principal component analysis coupled with optical flow-based registration algorithm were used in RDDR. Then, the local low rank constraint on the motion compensated time series images was applied for the DCT-MPI reconstruction. One healthy mini pig and two patient datasets were used to evaluate the proposed MC-LLR algorithm. Results show that the present method achieved satisfactory image quality with higher CNRs, smaller rRMSEs, and more accurate hemodynamic parameter maps.

Chest tomosynthesis (CTS) is a newly developed imaging technique which provides pseudo-3D volume anatomical information of thorax from limited-angle projections and contains much less of superimposed anatomy than the chest X-ray radiography. One of the relatively common problems in CTS is the patient respiratory motion during image acquisition, which negatively impacts the detectability. In this work, we propose a sin-quadratic model to analyze the respiratory motion during CTS scan, which is a real time method where the respiratory signal is generated by extracting the motion of diaphragm from projection radiographs. According to the estimated respiratory signal, the CTS projections were then amplitude-based sorted into four to eight phases, and an iterative reconstruction strategy with total variation regularization was adopted to reconstruct the CTS images at each phase. Simulated digital XCAT phantom data and three sets of patient data were adopted for the experiments to validate the performance of the sin-quadratic model and its application in four dimensional (4D) CTS reconstruction. Results of the XCAT phantom simulation study show that the correlation coefficient between the extracted respiratory signal and the originally designed respiratory signal is 0.9964, which suggests that the proposed model could exactly extract the respiratory signal from CTS projections. The 4D CTS reconstructions of both the phantom data and the patient data show clear reduction of motion-induced blur.

Megavoltage computed tomography (MVCT) plays a crucial role in patient positioning and dose reconstruction during tomotherapy. However, due to the limited scan field of view (sFOV), the entire cross-section of certain patients may not be fully covered, resulting in projection data truncation. Truncation artifacts in MVCT can compromise registration accuracy with the planned kilovoltage computed tomography (KVCT) and hinder subsequent MVCT-based adaptive planning. To address this issue, we propose a Prior-FOVNet to correct the truncation artifacts and extend the field of view (eFOV) by leveraging material and shape priors learned from the KVCT of the same patient. Specifically, to address the intensity discrepancies between different imaging modalities, we employ a contrastive learning-based GAN, named TransNet, to transform KVCT images into synthesized MVCT (sMVCT) images. The sMVCT images, along with pre-corrected MVCT images obtained via sinogram extrapolation, are then input into a Swin Transformer-based image inpainting network for artifact correction and FOV extension. Experimental results using both simulated and real patient data demonstrate that our method outperforms existing truncation correction techniques in reducing truncation artifacts and reconstructing anatomical structures beyond the sFOV. It achieves the lowest MAE of 23.8 ± 5.6 HU and the highest SSIM of 97.8 ± 0.6 across the test dataset, thereby enhancing the reliability and clinical applicability of MVCT in adaptive radiotherapy.