Dr. Barbara A. Wetmore is a toxicologist at the Center for Computational Toxicology and Exposure within the Office of Research and Development at the U.S. Environmental Protection Agency. Dr. Wetmore received her Ph.D. in toxicology from North Carolina State University. Her current research focuses on the development and assessment of new approach methods (NAMs) that harness in vitro experimental data and in silico modeling to evaluate commercial chemicals for human health risks and inform chemical testing priorities. She specializes in in vitro toxicokinetics and in vitro–in vivo extrapolation (IVIVE) modeling, tools that facilitate the incorporation of dosimetry and population variability into in vitro evaluations to enable risk-based priority setting. During her professional career, she has worked in various disciplines, starting in traditional mechanistic toxicology research for hazard identification and transitioning to the use of in vitro and omics tools and systems biology approaches before her current work. Dr. Wetmore has served as a subject matter expert and on committees for the U.S. National Academy of Sciences, the Organization for Economic Co-operation and Development (OECD), the European Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM), the United Nations Environment Programme, the U.S. Food and Drug Administration, and Health Canada.