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A sol-gel thiocyanatopropyl-functionalized silica sorbent was synthesized and employed for an automated on-line microcolumn preconcentration platform as a front-end to inductively coupled plasma atomic emission spectroscopy (ICP-AES) for the simultaneous determination of Cd(II), Pb(II), Cu(II), Cr(III), Co(II), Ni(II), Zn(II), Mn(II), Hg(II), and V(II). The developed system is based on an easy-to-repack microcolumn construction integrated into a flow injection manifold coupled directly to ICP-AES’s nebulizer. After on-line extraction/preconcentration of the target analyte onto the surface of the sorbent, successive elution with 1.0 mol L−1 HNO3 was performed. All main chemical and hydrodynamic factors affecting the effectiveness of the system were thoroughly investigated and optimized. Under optimized experimental conditions, for 60 s preconcentration time, the enhancement factor achieved for the target analytes was between 31 to 53. The limits of detection varied in the range of 0.05 to 0.24 μg L−1, while the limits of quantification ranged from 0.17 to 0.79 μg L−1. The precision of the method was expressed in terms of relative standard deviation (RSD%) and was less than 7.9%. Furthermore, good method accuracy was observed by analyzing three certified reference materials. The proposed method was also successfully employed for the analysis of environmental water samples.
Natalia Manousi; Abuzar Kabir; Kenneth Furton; George Zachariadis; Aristidis Anthemidis. Multi-Element Analysis Based on an Automated On-Line Microcolumn Separation/Preconcentration System Using a Novel Sol-Gel Thiocyanatopropyl-Functionalized Silica Sorbent Prior to ICP-AES for Environmental Water Samples. Molecules 2021, 26, 4461 .
AMA StyleNatalia Manousi, Abuzar Kabir, Kenneth Furton, George Zachariadis, Aristidis Anthemidis. Multi-Element Analysis Based on an Automated On-Line Microcolumn Separation/Preconcentration System Using a Novel Sol-Gel Thiocyanatopropyl-Functionalized Silica Sorbent Prior to ICP-AES for Environmental Water Samples. Molecules. 2021; 26 (15):4461.
Chicago/Turabian StyleNatalia Manousi; Abuzar Kabir; Kenneth Furton; George Zachariadis; Aristidis Anthemidis. 2021. "Multi-Element Analysis Based on an Automated On-Line Microcolumn Separation/Preconcentration System Using a Novel Sol-Gel Thiocyanatopropyl-Functionalized Silica Sorbent Prior to ICP-AES for Environmental Water Samples." Molecules 26, no. 15: 4461.
In this study a simple and sensitive on-line sorbent extraction platform coupled with flame atomic absorption spectrometry for trace metals determination was developed. The system utilized for the first time a novel sol-gel thiocyanatopropyl functionalized silica as adsorbent for metal’s separation and preconcentration. The main factors affecting the performance of the on-line system were investigated and optimized. The effect of potential interfering species that occur naturally in environmental and biological samples, as well as some toxic elements, was evaluated. Under optimum conditions the enhancement factors ranged between 73 and 152 for the target analytes. The LODs of the proposed methods were 0.15 μg L−1 for Cd(II), 0.5 μg L−1 for Co(II), 0.5 μg L−1 for Cu(II) and 1.9 μg L−1 for Pb(II) for 120 s preconcentration time. The relative standard deviation values for all elements were less than 3.8%, indicating good method precision. Moreover, the sol-gel thiocyanatopropyl functionalized silica-packed microcolumns exhibited limited flow resistance and excellent packing reproducibility. Finally, the proposed method was utilized for the analysis of environmental and biological samples.
Natalia Manousi; Abuzar Kabir; Kenneth Furton; George Zachariadis; Aristidis Anthemidis. Automated Solid Phase Extraction of Cd(II), Co(II), Cu(II) and Pb(II) Coupled with Flame Atomic Absorption Spectrometry Utilizing a New Sol-Gel Functionalized Silica Sorbent. Separations 2021, 8, 100 .
AMA StyleNatalia Manousi, Abuzar Kabir, Kenneth Furton, George Zachariadis, Aristidis Anthemidis. Automated Solid Phase Extraction of Cd(II), Co(II), Cu(II) and Pb(II) Coupled with Flame Atomic Absorption Spectrometry Utilizing a New Sol-Gel Functionalized Silica Sorbent. Separations. 2021; 8 (7):100.
Chicago/Turabian StyleNatalia Manousi; Abuzar Kabir; Kenneth Furton; George Zachariadis; Aristidis Anthemidis. 2021. "Automated Solid Phase Extraction of Cd(II), Co(II), Cu(II) and Pb(II) Coupled with Flame Atomic Absorption Spectrometry Utilizing a New Sol-Gel Functionalized Silica Sorbent." Separations 8, no. 7: 100.
In recent years, there has been an increase in public perception of the detrimental side-effects of fluoride to human health due to its effects on teeth and bones. Today, there is a plethora of techniques available for the removal of fluoride from drinking water. Among them, adsorption is a very prospective method because of its handy operation, cost efficiency, and high selectivity. Along with efforts to assist fluoride removal from drinking waters, extensive attention has been also paid to the accurate measurement of fluoride in water. Currently, the analytical methods that are used for fluoride determination can be classified into chromatographic methods (e.g., ionic chromatography), electrochemical methods (e.g., voltammetry, potentiometry, and polarography), spectroscopic methods (e.g., molecular absorption spectrometry), microfluidic analysis (e.g., flow injection analysis and sequential injection analysis), titration, and sensors. In this review article, we discuss the available techniques and the ongoing effort for achieving enhanced fluoride removal by applying novel adsorbents such as carbon-based materials (i.e., activated carbon, graphene oxide, and carbon nanotubes) and nanostructured materials, combining metals and their oxides or hydroxides as well as natural materials. Emphasis has been given to the use of lanthanum (La) in the modification of materials, both activated carbon and hybrid materials (i.e., La/Mg/Si-AC, La/MA, LaFeO3 NPs), and in the use of MgO nanostructures, which are found to exhibit an adsorption capacity of up to 29,131 mg g−1. The existing analytical methodologies and the current trends in analytical chemistry for fluoride determination in drinking water are also discussed.
Athanasia Tolkou; Natalia Manousi; George Zachariadis; Ioannis Katsoyiannis; Eleni Deliyanni. Recently Developed Adsorbing Materials for Fluoride Removal from Water and Fluoride Analytical Determination Techniques: A Review. Sustainability 2021, 13, 7061 .
AMA StyleAthanasia Tolkou, Natalia Manousi, George Zachariadis, Ioannis Katsoyiannis, Eleni Deliyanni. Recently Developed Adsorbing Materials for Fluoride Removal from Water and Fluoride Analytical Determination Techniques: A Review. Sustainability. 2021; 13 (13):7061.
Chicago/Turabian StyleAthanasia Tolkou; Natalia Manousi; George Zachariadis; Ioannis Katsoyiannis; Eleni Deliyanni. 2021. "Recently Developed Adsorbing Materials for Fluoride Removal from Water and Fluoride Analytical Determination Techniques: A Review." Sustainability 13, no. 13: 7061.
It is challenging to establish a correlation between the agronomical practices and the volatile profile of high-value agricultural products. In this study, the volatile metabolome of walnut oils from conventional and organic farming type was explored by HS-SPME-GC-MS. The SPME protocol was optimized after evaluating the effects of extraction time, extraction temperature, and sample mass. The optimum parameters involved the extraction of 0.500 g walnut oil at 40 °C within 60 min. Twenty Greek walnut oils produced with conventional and organic farming were analyzed and 41 volatile compounds were identified. The determined compounds were semi-quantified, and further processed with chemometrics. Agglomerative hierarchical clustering (AHC) and principal component analysis (PCA) were used. A robust classification model was developed using sparse partial least squares–discriminant analysis (sPLS-DA) for the discrimination of walnut oils into conventional and organic, establishing volatile markers that could be used to guarantee the type of farming.
Natasa P. Kalogiouri; Natalia Manousi; Erwin Rosenberg; George A. Zachariadis; Adamantini Paraskevopoulou; Victoria Samanidou. Exploring the volatile metabolome of conventional and organic walnut oils by solid-phase microextraction and analysis by GC-MS combined with chemometrics. Food Chemistry 2021, 363, 130331 .
AMA StyleNatasa P. Kalogiouri, Natalia Manousi, Erwin Rosenberg, George A. Zachariadis, Adamantini Paraskevopoulou, Victoria Samanidou. Exploring the volatile metabolome of conventional and organic walnut oils by solid-phase microextraction and analysis by GC-MS combined with chemometrics. Food Chemistry. 2021; 363 ():130331.
Chicago/Turabian StyleNatasa P. Kalogiouri; Natalia Manousi; Erwin Rosenberg; George A. Zachariadis; Adamantini Paraskevopoulou; Victoria Samanidou. 2021. "Exploring the volatile metabolome of conventional and organic walnut oils by solid-phase microextraction and analysis by GC-MS combined with chemometrics." Food Chemistry 363, no. : 130331.
A novel magnetic solid phase material based on a micro–meso porous activated carbon/Fe3O4 nanocomposite was used to extract caffeine from surface water samples. The method is efficient and rapid, and has minimum solvent consumption.
Natalia Manousi; Eleni A. Deliyanni; Erwin Rosenberg; George A. Zachariadis. Magnetic solid-phase extraction of caffeine from surface water samples with a micro–meso porous activated carbon/Fe3O4 nanocomposite prior to its determination by GC-MS. RSC Advances 2021, 11, 19492 -19499.
AMA StyleNatalia Manousi, Eleni A. Deliyanni, Erwin Rosenberg, George A. Zachariadis. Magnetic solid-phase extraction of caffeine from surface water samples with a micro–meso porous activated carbon/Fe3O4 nanocomposite prior to its determination by GC-MS. RSC Advances. 2021; 11 (32):19492-19499.
Chicago/Turabian StyleNatalia Manousi; Eleni A. Deliyanni; Erwin Rosenberg; George A. Zachariadis. 2021. "Magnetic solid-phase extraction of caffeine from surface water samples with a micro–meso porous activated carbon/Fe3O4 nanocomposite prior to its determination by GC-MS." RSC Advances 11, no. 32: 19492-19499.
Pesticides are excessively used in agriculture to improve the quality of crops by eliminating the negative effects of pests. Among the different groups of pesticides, triazine pesticides are a group of compounds that contain a substituted C3H3N3 heterocyclic ring, and they are widely used. Triazine pesticides can be dangerous for humans as well as for the aquatic environment due to their high toxicity and endocrine disrupting effect. However, the concentration of these chemical compounds in water samples is low. Moreover, other compounds that may exist in the water samples can interfere with the determination of triazine pesticides. As a result, it is important to develop sample preparation methods that provide preconcentration of the target analyte and sufficient clean-up of the samples. Recently, a wide variety of novel microextraction and miniaturized extraction techniques (e.g., solid-phase microextraction and liquid-phase microextraction, stir bar sorptive extraction, fabric phase sorptive extraction, dispersive solid-phase extraction, magnetic solid-phase extraction etc.) have been developed. In this review we aim to discuss the recent advances regarding the extraction of triazine pesticides from environmental water samples. Emphasis will be given to novel sample preparation methods and novel sorbents developed for sorbent-based extraction techniques. This article is protected by copyright. All rights reserved
Natalia Manousi; Abuzar Kabir; George A. Zachariadis. Recent advances in the extraction of triazine herbicides from water samples. Journal of Separation Science 2021, 1 .
AMA StyleNatalia Manousi, Abuzar Kabir, George A. Zachariadis. Recent advances in the extraction of triazine herbicides from water samples. Journal of Separation Science. 2021; ():1.
Chicago/Turabian StyleNatalia Manousi; Abuzar Kabir; George A. Zachariadis. 2021. "Recent advances in the extraction of triazine herbicides from water samples." Journal of Separation Science , no. : 1.
Flower waters, also known as aromatic waters, hydrosols, or herbal distillates, are typically considered to be by-products of essential oil. However, because of their bioactive content, flower waters currently exhibit various applications in the food industry as flavoring agents and food sanitizers. In this study, inductively coupled plasma–atomic emission spectrometry (ICP-AES) was employed for the assessment of the elemental composition (i.e., Ag, Al, B, Ba, Ca, Cd, Co, Cr, Cu, Fe, Mg, Mn, Ni, Pb, and Zn) of several flower waters. The reported method was optimized and validated in terms of linearity, limits of detections (LODs), limits of quantifications (LOQs), accuracy, and precision. The relative recoveries of the proposed method were between 80.0% and 120.0%, while the relative standard deviation values were less than 9.8%. The LODs and LOQs of the ICP-AES method ranged between 0.8 μg L−1(Cr) - 73.5 μg L−1 (Al), and between 2.5 μg L−1 (Cr) - 245.0 μg L−1 (Al), respectively . The validated ICP-AES method was successfully employed for the analysis of a variety of flower water samples.
N. Manousi; N. P. Kalogiouri; L. Kokokiris; A. Anthemidis; G. A. Zachariadis. Rapid Multielemental Inductively Coupled Plasma–Atomic Emission Spectrometric (ICP-AES) Method for the Assessment of the Quality of Flower Waters. Analytical Letters 2021, 1 -9.
AMA StyleN. Manousi, N. P. Kalogiouri, L. Kokokiris, A. Anthemidis, G. A. Zachariadis. Rapid Multielemental Inductively Coupled Plasma–Atomic Emission Spectrometric (ICP-AES) Method for the Assessment of the Quality of Flower Waters. Analytical Letters. 2021; ():1-9.
Chicago/Turabian StyleN. Manousi; N. P. Kalogiouri; L. Kokokiris; A. Anthemidis; G. A. Zachariadis. 2021. "Rapid Multielemental Inductively Coupled Plasma–Atomic Emission Spectrometric (ICP-AES) Method for the Assessment of the Quality of Flower Waters." Analytical Letters , no. : 1-9.
Bioanalysis is the scientific field of the quantitative determination of xenobiotics (e.g., drugs and their metabolites) and biotics (e.g., macromolecules) in biological matrices. The most common samples in bioanalysis include blood (i.e., serum, plasma and whole blood) and urine. However, the analysis of alternative biosamples, such as hair and nails are gaining more and more attention. The main limitations for the determination of small organic compounds in biological samples is their low concentration in these matrices, in combination with the sample complexity. Therefore, a sample preparation/analyte preconcentration step is typically required. Currently, the development of novel microextraction and miniaturized extraction techniques, as well as novel adsorbents for the analysis of biosamples, in compliance with the requirements of Green Analytical Chemistry, is in the forefront of research in analytical chemistry. Graphene oxide (GO) is undoubtedly a powerful adsorbent for sample preparation that has been successfully coupled with a plethora of green extraction techniques. GO is composed of carbon atoms in a sp2 single-atom layer of a hybrid connection, and it exhibits high surface area, as well as good mechanical and thermal stability. In this review, we aim to discuss the applications of GO and functionalized GO derivatives in microextraction and miniaturized extraction techniques for the determination of small organic molecules in biological samples.
Natalia Manousi; Orfeas-Evangelos Plastiras; Eleni Deliyanni; George Zachariadis. Green Bioanalytical Applications of Graphene Oxide for the Extraction of Small Organic Molecules. Molecules 2021, 26, 2790 .
AMA StyleNatalia Manousi, Orfeas-Evangelos Plastiras, Eleni Deliyanni, George Zachariadis. Green Bioanalytical Applications of Graphene Oxide for the Extraction of Small Organic Molecules. Molecules. 2021; 26 (9):2790.
Chicago/Turabian StyleNatalia Manousi; Orfeas-Evangelos Plastiras; Eleni Deliyanni; George Zachariadis. 2021. "Green Bioanalytical Applications of Graphene Oxide for the Extraction of Small Organic Molecules." Molecules 26, no. 9: 2790.
The quantitative determination of xenobiotic compounds, as well as biotics in biological matrices, is generally described with the term bioanalysis. Due to the complexity of biofluids, in combination with the low concentration of the small molecules, their determination in biological matrices is a challenging procedure. Apart from the conventional solid-phase extraction, liquid-liquid extraction, protein precipitation, and direct injection approaches, nowadays, a plethora of microextraction and miniaturized extraction techniques have been reported. Furthermore, the development and evaluation of novel extraction adsorbents for sample preparation has become a popular research field. Metal-organic frameworks (MOFs) are novel materials composed of metal ions or clusters in coordination with organic linkers. Unequivocally, MOFs are gaining more and more attention in analytical chemistry due to their superior properties, including high surface area and tunability of pore size and functionality. This review discusses the utilization of MOFs in the sample preparation of biological samples for the green extraction of small organic molecules. Their common preparation and characterization strategies are discussed, while emphasis is given to their applications for green sample preparation.
Natalia Manousi; Orfeas-Evangelos Plastiras; Natasa Kalogiouri; Constantinos Zacharis; George Zachariadis. Metal-Organic Frameworks in Bioanalysis: Extraction of Small Organic Molecules. Separations 2021, 8, 60 .
AMA StyleNatalia Manousi, Orfeas-Evangelos Plastiras, Natasa Kalogiouri, Constantinos Zacharis, George Zachariadis. Metal-Organic Frameworks in Bioanalysis: Extraction of Small Organic Molecules. Separations. 2021; 8 (5):60.
Chicago/Turabian StyleNatalia Manousi; Orfeas-Evangelos Plastiras; Natasa Kalogiouri; Constantinos Zacharis; George Zachariadis. 2021. "Metal-Organic Frameworks in Bioanalysis: Extraction of Small Organic Molecules." Separations 8, no. 5: 60.
Fabric phase sorptive extraction (FPSE) is a recently introduced sample preparation technique that has attracted substantial interest of the scientific community dealing with bioanalysis. This technique is based on a permeable and flexible substrate made of fabric, coated with a sol-gel organic-inorganic sorbent. Among the benefits of FPSE are its tunable selectivity, adjustable porosity, minimized sample preparation workflow, substantially reduced organic solvent consumption, rapid extraction kinetics and superior extraction efficiency, many of which are well-known criteria for Green Analytical Chemistry. As such, FPSE has established itself as a leading green sample preparation technology of 21st century. In this review, we discuss the principal steps for the development of an FPSE method, the main method optimization strategies, as well as the applications of FPSE in bioanalysis for the extraction of a wide range of analytes (e.g., estrogens, benzodiazepines, androgens and progestogens, penicillins, anti-inflammatory drugs, parabens etc.).
Natalia Manousi; Abuzar Kabir; George A Zachariadis. Green bioanalytical sample preparation: fabric phase sorptive extraction. Bioanalysis 2021, 13, 693 -710.
AMA StyleNatalia Manousi, Abuzar Kabir, George A Zachariadis. Green bioanalytical sample preparation: fabric phase sorptive extraction. Bioanalysis. 2021; 13 (9):693-710.
Chicago/Turabian StyleNatalia Manousi; Abuzar Kabir; George A Zachariadis. 2021. "Green bioanalytical sample preparation: fabric phase sorptive extraction." Bioanalysis 13, no. 9: 693-710.
Capsule phase microextraction (CPME) is a recently introduced environmentally friendly sample preparation technique that integrates both filtration and stirring mechanism into the extraction device. In this study, CPME was employed for the first time for the extraction of four polycyclic aromatic hydrocarbons (naphthalene, fluorene, phenanthrene and pyrene) from water samples prior to their determination by gas chromatography-mass spectrometry (GC–MS). The microextraction capsules were made of two porous polypropylene tubes that are welded to each other; one tube contained the magnetic rod, and the other tube contained the sorbent. Various sol–gel hybrid sorbents were evaluated. Microextraction capsules containing sol‐gel poly(caprolactone)-poly(dimethylsiloxane)-poly(caprolactone) (PCAP-PDMS-PCAP) sorbent provided the highest extraction efficiency. The main parameters (e.g., adsorption time, sample volume, stirring rate, addition of salt, type of eluent, desorption time and elution volume) affecting the steps of the CPME procedure were evaluated. Under the selected conditions, limits of detection (signal/noise = 3.3) ranged between 0.03 and 0.07 ng mL−1 for the selected PAHs. The relative standard deviation for the within-day and between-days repeatability were lower than 7.7% and 8.5%, respectively. Moreover, the CPME method exhibited good linearity and reusability of the microextraction capsules. The method was successfully applied to the analysis of tap water, mineral water and lake water samples. Relative recoveries ranged between 94.3 and 109.8%. The herein reported green method could efficiently simplify the overall sample preparation process, since it overcomes the requirements of sample filtration before the extraction and the solvent evaporation and sample reconstitution after the extraction.
N. Manousi; A. Kabir; K.G. Furton; E. Rosenberg; G.A. Zachariadis. Capsule phase microextraction of selected polycyclic aromatic hydrocarbons from water samples prior to their determination by gas chromatography-mass spectrometry. Microchemical Journal 2021, 166, 106210 .
AMA StyleN. Manousi, A. Kabir, K.G. Furton, E. Rosenberg, G.A. Zachariadis. Capsule phase microextraction of selected polycyclic aromatic hydrocarbons from water samples prior to their determination by gas chromatography-mass spectrometry. Microchemical Journal. 2021; 166 ():106210.
Chicago/Turabian StyleN. Manousi; A. Kabir; K.G. Furton; E. Rosenberg; G.A. Zachariadis. 2021. "Capsule phase microextraction of selected polycyclic aromatic hydrocarbons from water samples prior to their determination by gas chromatography-mass spectrometry." Microchemical Journal 166, no. : 106210.
A novel magnetic graphene oxide nanocomposite modified with polyaniline ([email protected]) was synthesized and applied for the magnetic solid-phase extraction of polycyclic aromatic hydrocarbons (PAHs) (i.e. fluorene, phenanthrene and pyrene) and nitrated polycyclic aromatic hydrocarbons (N-PAHs) (i.e. 2-nitrofluorene, 9-nitroanthracene, 1-nitropyrene and 3-nitrofluoranthene) prior to their determination by gas chromatography-mass spectrometry. The prepared nanomaterial was characterized by scanning electron microscopy, X-ray diffraction, and Fourier transform-infrared spectroscopy. The main experimental parameters affecting the extraction and desorption steps of the MSPE procedure were investigated and optimized. Under optimum conditions, coefficients of determination (r2) ranged between 0.9970 and 0.9995, limits of detection (LODs, S/N = 3) ranged between 0.04–0.05 ng mL−1 for PAHs and 0.01–0.11 ng mL−1 for N-PAHs, while the relative standard deviation for intra-day and inter-day repeatability were lower than 10.0% for PAHs and N-PAHs. The method was successfully applied to the analysis of tap, mineral and river water samples. Relative recoveries in spiked water samples ranged between from 91.6 to 114% and from 92.3 to 110% for PAHs and N-PAHs, respectively. The proposed method is simple, rapid, sensitive and the [email protected] sorbent can be reused for at least 15 times without significant decrease in extraction recovery.
N. Manousi; E.A. Deliyanni; E. Rosenberg; G.A. Zachariadis. Ultrasound-assisted magnetic solid-phase extraction of polycyclic aromatic hydrocarbons and nitrated polycyclic aromatic hydrocarbons from water samples with a magnetic polyaniline modified graphene oxide nanocomposite. Journal of Chromatography A 2021, 1645, 462104 .
AMA StyleN. Manousi, E.A. Deliyanni, E. Rosenberg, G.A. Zachariadis. Ultrasound-assisted magnetic solid-phase extraction of polycyclic aromatic hydrocarbons and nitrated polycyclic aromatic hydrocarbons from water samples with a magnetic polyaniline modified graphene oxide nanocomposite. Journal of Chromatography A. 2021; 1645 ():462104.
Chicago/Turabian StyleN. Manousi; E.A. Deliyanni; E. Rosenberg; G.A. Zachariadis. 2021. "Ultrasound-assisted magnetic solid-phase extraction of polycyclic aromatic hydrocarbons and nitrated polycyclic aromatic hydrocarbons from water samples with a magnetic polyaniline modified graphene oxide nanocomposite." Journal of Chromatography A 1645, no. : 462104.
Background: Polycyclic aromatic hydrocarbons (PAHs) are common environmental contaminants consisting of two or more fused benzene rings. PAHs can be introduced into foodstuffs through different ways, such as smoking, roasting and grilling for meat and fish, absorption from the environment for edible oils, chemical treatment of crops for plant-based products, or contamination through packaging during storage. Due to the low concentrations of PAHs in foodstuffs, a clean-up and preconcentration sample preparation technique is of high importance. Until recently, solid-phase and liquid-liquid extraction were the most popular sample preparation techniques for the extraction of PAHs from food matrices. However, due to the fundamental drawbacks of those extraction procedures, a plethora of novel methods, including micro-extraction techniques and miniaturized extraction techniques, have been developed. Moreover, a wide variety of novel adsorbent materials (e.g., metal-organic frameworks, carbon-based materials, etc.) have been synthesized and applied for PAHs’ extraction. Objective: This review aims to discuss recent advances in the extraction techniques of PAHs from food samples, utilizing novel sample preparation approaches and adsorbents. Conclusion: Compared with the traditional sample preparation techniques, the herein discussed green miniaturized extraction and microextraction techniques offer multiple benefits, including simplicity, reduced sample preparation time, as well as reduced consumption of organic solvents.
Natalia Manousi. Green Miniaturized Extraction and Microextraction of Polycyclic Aromatic Hydrocarbons from Foods and Beverages. Current Analytical Chemistry 2021, 17, 461 -477.
AMA StyleNatalia Manousi. Green Miniaturized Extraction and Microextraction of Polycyclic Aromatic Hydrocarbons from Foods and Beverages. Current Analytical Chemistry. 2021; 17 (4):461-477.
Chicago/Turabian StyleNatalia Manousi. 2021. "Green Miniaturized Extraction and Microextraction of Polycyclic Aromatic Hydrocarbons from Foods and Beverages." Current Analytical Chemistry 17, no. 4: 461-477.
Background:: Nuts have been incorporated into guidelines for healthy eating since they contain considerable amounts of antioxidants and their effects are related to health benefits since they contribute to the prevention of nutritional deficiencies. The micronutrient characterization is based mainly on the determination of phenolics, which is the most abundant class of bioactive compounds in nuts. Terpenes constitute another class of bioactive compounds that are present in nuts and show high volatility. The analysis of phenolic compounds and terpenes is a very demanding task that requires optimization of the chromatographic conditions to improve the separation of the components. Moreover, nuts are rich in unsaturated fatty acids and they are therefore considered as cardioprotective. Gas chromatography is the predominant instrumental analytical technique for the determination of derivatized fatty acids and terpenes in food matrices, while high performance liquid chromatography is currently the most popular technique for the determination of phenolic compounds. Objective:: This review summarizes all the recent advances in the optimization of the chromatographic conditions for the determination of phenolic compounds, fatty acids and terpenes in nuts. Conclusion:: The state-of-the art in the technology available is critically discussed, exploring new analytical approaches to reduce the time of analysis and improve the performance of the chromatographic systems in terms of precision, reproducibility, limits of detection and quantification and overall quality of the results.
Natasa P. Kalogiouri; Natalia Manousi; Erwin Rosenberg; George A. Zachariadis; Victoria F. Samanidou. Advances in the Chromatographic Separation and Determination of Bioactive Compounds for Assessing the Nutrient Profile of Nuts. Current Analytical Chemistry 2021, 17, 495 -511.
AMA StyleNatasa P. Kalogiouri, Natalia Manousi, Erwin Rosenberg, George A. Zachariadis, Victoria F. Samanidou. Advances in the Chromatographic Separation and Determination of Bioactive Compounds for Assessing the Nutrient Profile of Nuts. Current Analytical Chemistry. 2021; 17 (4):495-511.
Chicago/Turabian StyleNatasa P. Kalogiouri; Natalia Manousi; Erwin Rosenberg; George A. Zachariadis; Victoria F. Samanidou. 2021. "Advances in the Chromatographic Separation and Determination of Bioactive Compounds for Assessing the Nutrient Profile of Nuts." Current Analytical Chemistry 17, no. 4: 495-511.
The trace element content of thirty-two nuts including almonds, walnuts, hazelnuts and pistachios available in a Greek market was determined by inductively coupled plasma atomic emission spectrometry (ICP-AES). Wet acid digestion using nitric acid (65%) took place in Teflon autoclaves. The limits of detection (LODs) and limits of quantification (LOQs) ranged between 0.01 (Mg)–2.52 (Cu) μg g−1 and 0.02 (Mg)–8.40 (Cu) μg g−1, respectively. Good method linearity (r2 > 0.9990) was observed for each element at the selected emission lines. The metals were quantified and one-way analysis of variance (ANOVA) was used to examine whether or not there were any statistically significant differences among the metal concentrations inside the different nut species.
Natasa Kalogiouri; Natalia Manousi; George Zachariadis. Determination of the Toxic and Nutrient Element Content of Almonds, Walnuts, Hazelnuts and Pistachios by ICP-AES. Separations 2021, 8, 28 .
AMA StyleNatasa Kalogiouri, Natalia Manousi, George Zachariadis. Determination of the Toxic and Nutrient Element Content of Almonds, Walnuts, Hazelnuts and Pistachios by ICP-AES. Separations. 2021; 8 (3):28.
Chicago/Turabian StyleNatasa Kalogiouri; Natalia Manousi; George Zachariadis. 2021. "Determination of the Toxic and Nutrient Element Content of Almonds, Walnuts, Hazelnuts and Pistachios by ICP-AES." Separations 8, no. 3: 28.
Forensic toxicology is the scientific field that is associated with death investigations, matters involving drugs determination, sports doping etc. In forensic toxicology, reliable qualitative and quantitative toxicological analysis of a wide variety of drugs with different chemical properties (e.g., amphetamines, benzodiazepines, cannabis and opiates) is required. Alternative biosamples including hair, nails, saliva, sweat, cerebrospinal fluid and dried blood spots can be efficiently used in forensic toxicology to provide necessary or additional information. These samples exhibit certain benefits towards conventional blood and urine samples, such as ease in collection, stability, and provision of useful information for a long time period. Gas chromatography and liquid chromatography coupled with mass detectors or tandem mass detectors are the most powerful instrumentations for the determination of analytes of interest in forensic toxicology. Sample preparation is required to make the analyte compatible with these instrumentations, to remove matrix interferences and to preconcentrate them. For this purpose, solid-phase extraction (SPE) and liquid-liquid extraction (LLE) have been widely used. However, since the development of green analytical chemistry that emerged from green chemistry, a plethora of microextraction and miniaturized extraction techniques have been developed. In this review article we aim to discuss the green sample preparation techniques of alternative biosamples in forensic toxicology reported during the last 10 years.
Natalia Manousi; Victoria Samanidou. Green sample preparation of alternative biosamples in forensic toxicology. Sustainable Chemistry and Pharmacy 2021, 20, 100388 .
AMA StyleNatalia Manousi, Victoria Samanidou. Green sample preparation of alternative biosamples in forensic toxicology. Sustainable Chemistry and Pharmacy. 2021; 20 ():100388.
Chicago/Turabian StyleNatalia Manousi; Victoria Samanidou. 2021. "Green sample preparation of alternative biosamples in forensic toxicology." Sustainable Chemistry and Pharmacy 20, no. : 100388.
Pistachios are a nutritionally beneficial food source widely consumed all over the world. Pistachios exhibit high content of antioxidants, vitamins and other beneficial micronutrients, including nutrient elements and rare earth elements (REEs). Considering that the concentration of REEs depends on the climate and soil characteristics that vary among different geographical regions, REEs could constitute markers responsible for the geographical discrimination of this nut type. In this study, Greek pistachios with a protected designation of origin (PDO) label from Aegina Island and Fthiotida and Turkish pistachios from Adana were analyzed with inductively coupled plasma mass spectrometry (ICP-MS) to assess their REE profile. La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm and Yb were determined and quantified. The quantification results were further analyzed using the main effect plot, permutational analysis of variance (PERMANOVA), nonmetric multidimensional scaling (nMDS), principal component analysis (PCA) and hierarchical clustering (HCA) to investigate the similarities between the pistachios. A decision tree (DT) was developed for the classification of pistachios according to their geographical origin proving to be a promising and reliable tool for verifying the authenticity of food products on the basis of their REE profile.
Natasa Kalogiouri; Natalia Manousi; Dimitris Klaoudatos; Thomas Spanos; Vilson Topi; George Zachariadis. Rare Earths as Authenticity Markers for the Discrimination of Greek and Turkish Pistachios Using Elemental Metabolomics and Chemometrics. Foods 2021, 10, 349 .
AMA StyleNatasa Kalogiouri, Natalia Manousi, Dimitris Klaoudatos, Thomas Spanos, Vilson Topi, George Zachariadis. Rare Earths as Authenticity Markers for the Discrimination of Greek and Turkish Pistachios Using Elemental Metabolomics and Chemometrics. Foods. 2021; 10 (2):349.
Chicago/Turabian StyleNatasa Kalogiouri; Natalia Manousi; Dimitris Klaoudatos; Thomas Spanos; Vilson Topi; George Zachariadis. 2021. "Rare Earths as Authenticity Markers for the Discrimination of Greek and Turkish Pistachios Using Elemental Metabolomics and Chemometrics." Foods 10, no. 2: 349.
Plant-based drinks are non-dairy milk alternative beverages that are nowadays widely consumed across the world. Among them, nut-based milk alternative beverages such as almond drink, walnut drink, and peanut drink are gaining more and more popularity. This study presents the development and validation of an inductively coupled plasma–optical emission spectrometry (ICP-OES) method for the determination of nutrient and toxic metals elements in nut-based drinks. The determined metals were Ag, Al, Ba, Ca, Cd, Co, Cr, Cu, Fe, In, Mg, Mn, Ni, Pb, and Zn. The mineralization process of drink samples was optimized in order to achieve complete dissolution. Under optimized conditions, mineralization of 2 g of the nut-based drinks was achieved by the addition of 3 mL of nitric acid and heating at 120°C for 60 min into Teflon autoclaves. The proposed method was validated in terms of linearity, accuracy, precision, limits of detection (LODs), and limits of quantification (LOQs). The relative standard deviations (RSD%) for all elements were 0.4–10.8%, and the relative recovery values (RR%) were 90.0–109.7%, demonstrating that the method offered good precision and accuracy. The LODs for the determined elements were found to be 0.03–1.08 mg kg−1, while the LOQs were found to be 0.10–3.23 mg kg−1. The developed method was successfully employed for the analysis of different commercial nut-based drinks (e.g., almond-based drinks, walnut-based drinks, peanut-based drinks etc.) obtained from the local market.
N. Manousi; G. A. Zachariadis. A Simple and Rapid Analytical Method for the Determination of Nutrient and Toxic Elements in Nut-Based Milk Alternative Beverages by ICP-OES. Food Analytical Methods 2021, 14, 1315 -1321.
AMA StyleN. Manousi, G. A. Zachariadis. A Simple and Rapid Analytical Method for the Determination of Nutrient and Toxic Elements in Nut-Based Milk Alternative Beverages by ICP-OES. Food Analytical Methods. 2021; 14 (7):1315-1321.
Chicago/Turabian StyleN. Manousi; G. A. Zachariadis. 2021. "A Simple and Rapid Analytical Method for the Determination of Nutrient and Toxic Elements in Nut-Based Milk Alternative Beverages by ICP-OES." Food Analytical Methods 14, no. 7: 1315-1321.
A novel sample preparation method based on the use of the Arrow solid-phase microextraction device was used to extract and preconcentrate volatile organic compounds (VOCs) from milk samples prior to their determination by gas chromatography–mass spectrometry (GC-MS). The experimental parameters of the solid-phase microextraction (SPME) Arrow method were evaluated in terms of fiber type, sample volume, extraction temperature, extraction time, stirring rate and salt addition. Under the optimum extraction conditions, the SPME Arrow was compared with conventional SPME fibers to evaluate the effectiveness of the SPME Arrow method. Evaluation of the conventional SPME procedure was also performed under optimized conditions, for appropriate method comparison. Due to the larger sorption phase volume of SPME Arrow, a higher sensitivity and reproducibility were observed for the determined chromatographic peaks in comparison with conventional SPME fibers. The use of Carbon wide range (WR) SPME Arrow/polydimethylsiloxane (CAR/PDMS) SPME Arrow fibers leads to a compound-dependent improvement of a factor of 4–5x over the classical SPME setup. Moreover, the relative standard deviation (RSD) of the total volatiles for a conventional SPME procedure was 12.5%, while for SPME Arrow it was 6.2%. Finally, the novel method was successfully employed for the analysis of commercially available milk samples. The findings of this study indicate that SPME Arrow can be effectively used for the determination of volatile organic compounds in complex food matrixes.
Natalia Manousi; Erwin Rosenberg; George A. Zachariadis. Solid-Phase Microextraction Arrow for the Sampling of Volatile Organic Compounds in Milk Samples. Separations 2020, 7, 75 .
AMA StyleNatalia Manousi, Erwin Rosenberg, George A. Zachariadis. Solid-Phase Microextraction Arrow for the Sampling of Volatile Organic Compounds in Milk Samples. Separations. 2020; 7 (4):75.
Chicago/Turabian StyleNatalia Manousi; Erwin Rosenberg; George A. Zachariadis. 2020. "Solid-Phase Microextraction Arrow for the Sampling of Volatile Organic Compounds in Milk Samples." Separations 7, no. 4: 75.
This study presents the determination of toxic and nutrient elements in vinegar samples using inductively coupled plasma – atomic emission spectrometry (ICP-AES). The determined elements were Pb, Ni, Cr, Cu, Mg, Zn, Fe, Al, Ba, Ca, Co, and Cd. The aim of this study was to develop a simple and rapid method for the elemental analysis of vinegar samples without sample dilution that can result in sensitivity loss and without acidic digestion that could significantly increase the time and complexity of the overall process. Therefore, direct analysis of vinegars was employed and parameters including the radiofrequency power and the sample uptake were evaluated, in order to have stable plasma conditions. Under the optimum conditions, vinegar samples with a maximum concentration of 6% v/v were analyzed using a radiofrequency power of 1350 W and a sample uptake of 1.5 L min−1. The proposed method was validated in terms of linearity, limit of detection (LOD), limit of quantification (LOQ), accuracy, and precision. The LODs were between 0.1 and 22.1 μg L−1, while the LOQs were between 0.3 and 73.0 μg L−1 for the examined trace elements. The developed method was successfully employed for the analysis of 10 different commercially available vinegar samples that included white grape vinegar, red wine vinegar, apple cider vinegar, and balsamic vinegar.
Ioanna P. Paktsevanidou; N. Manousi; G. A. Zachariadis. Development and Validation of an Inductively Coupled Plasma – Atomic Emission Spectrometry (ICP-AES) Method for Trace Element Determination in Vinegar. Analytical Letters 2020, 54, 2227 -2238.
AMA StyleIoanna P. Paktsevanidou, N. Manousi, G. A. Zachariadis. Development and Validation of an Inductively Coupled Plasma – Atomic Emission Spectrometry (ICP-AES) Method for Trace Element Determination in Vinegar. Analytical Letters. 2020; 54 (13):2227-2238.
Chicago/Turabian StyleIoanna P. Paktsevanidou; N. Manousi; G. A. Zachariadis. 2020. "Development and Validation of an Inductively Coupled Plasma – Atomic Emission Spectrometry (ICP-AES) Method for Trace Element Determination in Vinegar." Analytical Letters 54, no. 13: 2227-2238.