Issues of rising waste generation are calling for proper management and the sustainable control of waste. This study examines waste- and energy-relevant policies and strategies in Ghana and the stakeholders’ perceptions on such policies and strategies. It explores the gaps and challenges in national policy documents to guide the implementation of waste-to-energy projects in Ghana. The approach adopted includes a comprehensive review of relevant policy documents and key informant interviews with selected key stakeholders. Factors such as limited funding, inadequate logistics, expertise and infrastructure, growing population and negative attitudes of general public towards the environment, amongst others, are the concerns identified. Findings from the policy review revealed that capacity to harness energy from waste could be improved through appropriate technologies suitable for Ghana. Adequate institutional framework, stakeholders and mechanisms to explore opportunities to coordinate implementation of various policy strategies and interventions have been established. Streamlining strategies to constitute components to improve governance on waste management, improving financing to ensure sustainable investment in waste-to-energy projects, improving research on waste-to-energy technologies as well as enhancing public interest and education on proper waste management could enhance the implementation of national waste and energy policies for feasible up-scaling of waste-to-energy technologies in Ghana.