Degui Zhi is the founding chair of the Department of Bioinformatics and Systems Medicine, McWilliams School of Biomedical Informatics, UTHealth at Houston. He is the Glassell Family Professor and founding director of the Center for AI and Genome Informatics (AIGI). He received his Ph.D. in bioinformatics from the University of California, San Diego. He is interested in developing AI deep learning and informatics methods for biomedical big data. His current funded projects cover topics in AI-powered brain imaging and retina imaging, genetics, population genetics informatics, and EHR predictive modeling. He is also interested in using LLM and genitive AI for scientific discovery. He has been teaching deep learning for biomedical informatics courses since 2018. He is an elected fellow of the American College of Medical Informatics (ACMI).