Extemporaneous preparations are still widely prescribed for pediatric patients with special treatments of certain doses and/or combinations of drugs. Several problems related to extemporaneous preparations have been linked to the incidence of adverse events or a lack of therapeutic effectiveness. Developing nations are facing the challenges of compounding practices. The prevalence of compounded medication in developing nations must be explored to determine the urgency of compounding practices. Furthermore, the risks and challenges are described and explained through investigation and collection of numerous scientific articles from reputable databases, including Web of Science, Scopus, and PubMed. Pediatric patients need compounded medication related to the appropriate dosage form and dosage adjustment. Notably, it is important to observe extemporaneous preparations in order to provide patient-oriented medication.

Objective: This research aims to evaluate the effect of olive oil, tween 60, and span 20 on the physical properties of quercetin nanoemulgel. Methods: In this research, quercetin was formulated into nanoemulgel using a variation of olive oil, tween 60, span 20, and sodium alginate as a gelling agent. The nanoemulgel physical properties (pH, viscosity, and spreadability), stability, and particle size were tested. The data were measured and evaluated using Minitab®18 software; if the p-value<0.05, it is stated that there is a statistically significant difference in the formula. Results: The result showed that tween 60 has the greatest significant impact on pH, viscosity, and transmittance value with a p-value<0.05 for all, meanwhile span 20 has the greatest significant impact on the spreadability of the nanoemulgel preparations with a p-value<0.05 indicating that they are significantly different. Conclusion: This study reported that the effect of olive oil, tween 60 and span 20, with different variations, significantly impacts the physical properties (pH, viscosity, and spreadability) of the nanoemulgel.

Oriental Journal of Chemistry is a peer reviewed quarterly research journal of pure and applied chemistry. It publishes standard research papers in almost all thrust areas of current chemistry of academic and commercial importance. It provides a platform for rapid publication of quality research papers, reviews and chemistry letters. Oriental Journal of Chemistry is abstracted and indexed in almost all reputed National and International agencies.

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