Parasites are a selective force that shape host community structure and dynamics, but host communities can also influence parasitism. Understanding the dual nature from host-parasite interactions can be facilitated by quantifying the variation in parasite prevalence among host species and then comparing that variation to other ecological factors that are known to also shape host communities. Avian haemosporidian parasites (e.g. Plasmodium and Haemoproteus) are abundant and widespread representing an excellent model for the study of host-parasite interactions. Several geographic and environmental factors have been suggested to determine prevalence of avian haemosporidians in bird communities. However, it remains unknown whether host and parasite traits, represented by phylogenetic distances among species and degree of specialization in host-parasite relationships, can influence infection status. The aims of this study were to analyze factors affecting infection status in a bird community and to test whether the degree of parasite specialization on their hosts is determined by host traits. Our statistical analyses suggest that infection status is mainly determined by the interaction between host species and parasite lineages where tolerance and/or susceptibility to parasites plays an essential role. Additionally, we found that although some of the parasite lineages infected a low number of bird individuals, the species they infected were distantly related and therefore the parasites themselves should not be considered typical host specialists. Infection status was higher for generalist than for specialist parasites in some, but not all, host species. These results suggest that detected prevalence in a species mainly results from the interaction between host immune defences and parasite exploitation strategies wherein the result of an association between particular parasite lineages and particular host species is idiosyncratic.

Animals have developed a wide range of defensive mechanisms against parasites to reduce the likelihood of infection and its negative fitness costs. The uropygial gland is an exocrine gland that produces antimicrobial and antifungal secretions with properties used as a defensive barrier on skin and plumage. This secretion has been proposed to affect the interaction between avian hosts and their ectoparasites. Because uropygial secretions may constitute a defense mechanism against ectoparasites, this may result in a reduction in prevalence of blood parasites that are transmitted by ectoparasitic vectors. Furthermore, other studies pointed out that vectors could be attracted by uropygial secretions and hence increase the probability of becoming infected. Here we explored the relationship between uropygial gland size, antimicrobial activity of uropygial secretions and malaria infection in house sparrows Passer domesticus. A nested-PCR was used to identify blood parasites infection. Flow cytometry detecting absolute cell counting assessed antimicrobial activity of the uropygial gland secretion Uninfected house sparrows had larger uropygial glands and higher antimicrobial activity in uropygial secretions than infected individuals. We found a positive association between uropygial gland size and scaled body mass index, but only in uninfected sparrows. Female house sparrows had larger uropygial glands and higher antimicrobial activity of gland secretions than males. These findings suggest that uropygial gland secretions may play an important role as a defensive mechanism against malaria infection.

Avian malaria and related haemosporidians (genera Haemoproteus, Plasmodium and Leucocytozoon) infect most clades of bird. Although these parasites are present in almost all continents, they have been irregularly studied across different geographical regions. Despite the high bird diversity in Asia, the diversity of avian haemosporidians in this region is largely unknown. Moreover, anthropogenic changes to habitats in tropical regions may have a profound impact on the overall composition of haemosporidian communities. Here we analyzed the diversity and host association of bird haemosporidians from areas with different degrees of anthropogenic disturbance in Myanmar, revealing an unexplored diversity of these parasites (27% of newly-discovered haemosporidian lineages, and 64% of new records of host–parasite assemblages) in these tropical environments. This newly discovered diversity will be valuable for detecting host range and transmission areas of haemosporidian parasites. We also found slightly higher haemosporidian prevalence and diversity in birds from paddy fields than in individuals from urban areas and hills, thus implying that human alteration of natural environments may affect the dynamics of vector-borne diseases. These outcomes provide valuable insights for biodiversity conservation management in threatened tropical ecosystems.