Efficient targeted oncogenic KRASG12C degradation via first reversible-covalent PROTAC

Discovery of a Highly Potent and Selective Dual PROTAC Degrader of CDK12 and CDK13

Directed Evolution of a Plant Glycosyltransferase for Chemo- and Regioselective Glycosylation of Pharmaceutically Significant Flavonoids

Targeting Gatekeeper Mutations for Kinase Drug Discovery

Conformational Constrained 4-(1-Sulfonyl-3-indol)yl-2-phenylaminopyrimidine Derivatives as New Fourth-Generation Epidermal Growth Factor Receptor Inhibitors Targeting T790M/C797S Mutations

Discovery of D6808, a Highly Selective and Potent Macrocyclic c-Met Inhibitor for Gastric Cancer Harboring MET Gene Alteration Treatment