Twenty-one analogs were synthesized based on benzimidazole, incorporating a substituted benzaldehyde moiety (1–21). These were then screened for their acetylcholinesterase and butyrylcholinesterase inhibition profiles. All the derivatives except 13, 14, and 20 showed various inhibitory potentials, ranging from IC₅₀ values of 0.050 ± 0.001 µM to 25.30 ± 0.40 µM against acetylcholinesterase, and 0.080 ± 0.001 µM to 25.80 ± 0.40 µM against butyrylcholinesterase, when compared with the standard drug donepezil (0.016 ± 0.12 µM and 0.30 ± 0.010 µM, against acetylcholinesterase and butyrylcholinesterase, respectively). Compound 3 in both cases was found to be the most potent compound due to the presence of chloro groups at the 3 and 4 positions of the phenyl ring. A structure-activity relationship study was performed for all the analogs except 13, 14, and 20, further, molecular dynamics simulations were performed for the top two compounds as well as the reference compound in a complex with acetylcholinesterase and butyrylcholinesterase. The molecular dynamics simulation analysis revealed that compound 3 formed the most stable complex with both acetylcholinesterase and butyrylcholinesterase, followed by compound 10. As compared to the standard inhibitor donepezil both compounds revealed greater stabilities and higher binding affinities for both acetylcholinesterase and butyrylcholinesterase.

The photocatalytic degradation of Rhodamine 6G dye was achieved using a Ficus elastica (F. elastic) leaf extract mediated zinc oxide-zirconium dioxide nanocatalyst (ZnO-ZrO₂ NC) under stimulated solar light, resulting in a substantial increase in photocatalytic activity at the highest calcination temperature. The crystal phase and crystallite size were determined using an X-ray diffractometer (XRD), and the degree of crystallinity was observed to rise with increasing calcination temperature. Energy dispersive X-ray (EDX) was used to investigate the elemental composition and purity of ZnO-ZrO₂ NC. Scanning electron microscopy (SEM) was used to investigate the surface morphology, and the morphological characteristics were altered when the calcination temperature was varied. For the ZnO-ZrO₂ NC calcined at 100, 300, 600, and 900 °C, the average grain size determined from SEM images is 79.56 nm, 98.78 (2) nm, 54.86 (2) nm, and 67.43 (2) nm, respectively. Using diffuse reflectance spectroscopy (DRS) data, the optical band gap energy was calculated using a Tauc’s plot. The ZnO in ZnO-ZrO₂ NC calcined at 100, 300, 600, and 900 °C had band gap energies of 3.31, 3.36, 3.38, and 3.29 eV. Similarly, ZrO₂ in ZnO-ZrO₂ NC calcined at 100, 300, 600, and 900 °C had band gap energies of 3.96, 3.99, 3.97, and 4.01 eV, respectively. Fourier transform infrared (FTIR) spectroscopy was used to identify the presence of various functional groups. The photocatalytic activity was also examined in relation to calcination temperature, pH, starting concentration, and catalyst dosage. Enhanced photocatalytic activity was observed at pH 11 and 15 ppm initial concentration with a catalyst dose of 25 mg. The photocatalytic activity of the sample calcined at 900 °C was the highest, with 98.94 percent of the dye mineralized in 330 min at a degradation rate of 0.01261/min.

Bergenia ciliate (B. ciliate) leaf extract was used as a reducing and stabilizing agent for the synthesis of silver-copper oxide nanocomposite (Ag-CuO NC). Scanning and transmission electron microscopies (SEM and TEM) were used to examine the structural morphology, and the average particle size was determined to be 47.65 nm. The phase confirmation and crystalline structure were examined through the X-ray diffraction (XRD) technique, where cubic and monoclinic geometries were assigned to Ag and CuO. The energy dispersive X-ray (EDX), Fourier transform infrared (FTIR) and ultra-violet and visible (UV-Visible) spectroscopies were operated to analyse the elemental composition, functional groups and light absorption phenomena of the Ag-CuO NC. Under the full light spectrum, the photodegradation of Rhodamine 6G was recorded, and 99.42 percent of the dye degraded in 80 min. The Agar well diffusion method was followed to perform antibacterial activity against selected pathogens, and the activity was found to increase with increasing concentration of Ag-CuO NC. The ABTS free radical scavenging activity suggests that the activity of Ag-CuO NC is higher than ascorbic acid.

The present study is an attempt to improve thermal, mechanical and electrical properties of poly (methyl methacrylate) (PMMA). For this purpose, vinyltriethoxysilane (VTES) was grafted covalently on the surface of graphene oxide (GO). This VTES functionalized graphene oxide (VGO) was dispersed in the PMMA matrix using the solution casting method. The morphology of the resultant PMMA/VGO nanocomposites was analyzed by SEM indicating well-dispersed VGO in the PMMA matrix. Thermal stability, tensile strength and thermal conductivity increased by 90%, 91% and 75%, respectively, whereas volume electrical resistivity and surface electrical resistivity reduced to 9.45 × 10⁵ Ω/cm and 5.45 × 10⁷ Ω/cm², respectively.