Horizontal well drills are difficult to operate and require high borehole cleaning operations. The impact of cuttings accumulation on friction and torque cannot be ignored. In the process of horizontal well drilling, it is very easy to form a cuttings bed in the highly inclined eccentric annulus. The formation of the cuttings bed will not only increase the friction torque but also have a greater impact on the annulus flow. Based on the application of gas drilling in horizontal wells, this paper uses laboratory experiments to study the influence of cuttings with different particle sizes and lithology on the friction coefficient between the drill string and the borehole wall of the horizontal well section. In addition, in view of the difficulty in the migration of cuttings in gas drilling horizontal wells and the formation of cuttings deposits, this paper carries out an experimental study on the effect of the cuttings bed on drill pipe coating height and cuttings bed thickness on friction coefficient. Experimental results show that the friction coefficient of gas drilling horizontal wells is about 0.44–0.58. When the coating height of the cuttings on the drill pipe exceeds a certain value (26 mm), the friction coefficient tends to be stable, but its value is as high as about 0.55. When the thickness of the accumulation of cuttings exceeds a certain value (10 mm), the subsidence hindering effect between the particles in the cuttings bed is weakened, so the friction coefficient of the casing section and the open hole section tends to be stable, about 0.53.