In this study, a novel series of 5-amino-1H-pyrazole derivatives involving 2-furoyl moieties were synthesized in good yields from 2-cyano-3 ethoxyacrylonitrile or ethyl-2-cyano-3-ethoxyacrylate and of various furan-2-carbohydrazide compounds under microwave irradiation. We studied the reactivity of these new compounds toward the orthoesters using the same methodology. All structures were confirmed by analytical and spectral (FT-IR, ¹H NMR, ¹³C NMR, and elemental analysis) techniques. Graphical Abstract

In the current study, we reported a cost-effective, simple strategy for the synthesis and reactivity of a novel series of chromenopyridine derivatives involving 2,4-diamino-3-carbonitrile moieties. These new compounds were synthesized in good yields from malononitrile and various chromene derivatives as a precursor, which was prepared by the reduction of iminocoumarin derivatives. The formed iminocoumarin was obtained by Knoevenagel condensation from malononitrile and different aromatic aldehydes. These novel chromenopyridine derivatives were further reacted with triethyl orthoformate under microwave irradiation to afford the final compounds, namely "chromenopyridine formimidate." The structures of all molecules were characterized by FT-IR, 1H NMR, 13C NMR, and elemental analysis.