Hawthorn (Crataegus) is a plant of the Rosaceae family and is widely grown throughout the world as one of the medicinal and edible plants, known as the “nutritious fruit” due to its richness in bioactive substances. Preparations derived from it are used in the formulation of dietary supplements, functional foods, and pharmaceutical products. Rich in amino acids, minerals, pectin, vitamin C, chlorogenic acid, epicatechol, and choline, hawthorn has a high therapeutic and health value. Many studies have shown that hawthorn has antioxidant, anti-inflammatory, anticancer, anti-cardiovascular disease, and digestive enhancing properties. This is related to its bioactive components such as polyphenols (chlorogenic acid, proanthocyanidin B2, epicatechin), flavonoids (proanthocyanidins, mucoxanthin, quercetin, rutin), and pentacyclic triterpenoids (ursolic acid, hawthornic acid, oleanolic acid), which are also its main chemical constituents. This paper briefly reviews the chemical composition, nutritional value, food applications, and the important biological and pharmacological activities of hawthorn. This will contribute to the development of functional foods or nutraceuticals from hawthorn.

C₁₈H₁₂F₄O, triclinic, P1̄ (no. 2), a = 7.9400(8) Å, b = 8.1071(9) Å, c = 13.3238(15) Å, α = 89.394(9)° , β = 76.343(9)° , γ = 63.411(11)° , V = 740.79(15) ų, Z = 2, Rgt (F) = 0.0472, wRref (F²) = 0.1244, T = 293 K.

C₃₇H₅₂O₃, orthorhombic, P2₁2₁2₁ (no. 19), a = 8.2477(3) Å, b = 19.2976(7) Å, c = 19.6372(4) Å, V = 3125.47(17) ų, Z = 4, R _gt (F) = 0.0558, wR _ref (F ²) = 0.1728, T = 293 K. CCDC No.: 2283347

Correction for ‘Discovery of dibenzylbutane lignan LCA derivatives as potent anti-inflammatory agents’ by Zhen Wang et al. , RSC Med. Chem. , 2024, https://doi.org/10.1039/d4md00053f.

A carbamothioate-mediated method for synthesizing benzenesulfonyl fluorides via Selectfluor™ oxidation is reported, enabling compatibility with α,β-unsaturated chalcone derivatives without Michael addition side reactions. This approach offers moderate yields, broad functional group tolerance, and applications in covalent drug discovery, facilitating the incorporation of sulfonyl fluoride warheads into complex electrophilic scaffolds.