Parkinson’s disease primarily affects people in their later years, and there is no cure for this disease; however, the proper medication of patients can lead to a healthy life. Appropriate care and treatment of Parkinson’s disease can be improved if the disease is detected in its early phase. Thus, there is an urgent need to develop novel methods for early illness detection. With this aim for the early detection of Parkinson’s disease, in this study, we utilized hand-drawn images by Parkinson’s disease patients to effectively reduce the clinical experimental costs for poor people. Initially, discrete wavelet coefficients were extracted for each pattern of images; thereafter, on top of that, histograms of oriented gradient features were also extracted to refine the level of features. Thereafter, the fusion approach-based features were fed to various machine learning algorithms. The proposed work was validated on two different datasets, each of which consisted of various patterns, including spiral, wave, cube, and triangle images. The main contribution of this work is the fusion of two feature extraction techniques, which are histograms of oriented gradient features and discrete wavelet transform coefficients. The extracted features were then provided as input into different machine learning algorithms. In our experiment(s) on two datasets, the results achieved an accuracy of 79.7% and 97.8%, respectively, for all four discrete wavelet transform coefficients. This work demonstrates the utilities of fusion-based features for all four discrete wavelet transformation coefficients to detect Parkinson’s disease, using image processing and machine learning techniques.

The rapid advancement of next-generation sequencing (NGS) technology and the expanding availability of NGS datasets have led to a significant surge in biomedical research. To better understand the molecular processes, underlying cancer and to support its development, diagnosis, prediction, and therapy; NGS data analysis is crucial. However, the NGS multi-layer omics high-dimensional dataset is highly complex. In recent times, some computational methods have been developed for cancer omics data interpretation. However, various existing methods face challenges in accounting for diverse types of cancer omics data and struggle to effectively extract informative features for the integrated identification of core units. To address these challenges, we proposed a hybrid feature selection (HFS) technique to detect optimal features from multi-layer omics datasets. Subsequently, this study proposes a novel hybrid deep recurrent neural network-based model DOMSCNet to classify stomach cancer. The proposed model was made generic for all four multi-layer omics datasets. To observe the robustness of the DOMSCNet model, the proposed model was validated with eight external datasets. Experimental results showed that the SelectKBest-maximum relevancy minimum redundancy-Boruta (SMB), HFS technique outperformed all other HFS techniques. Across four multi-layer omics datasets and validated datasets, the proposed DOMSCNet model outdid existing classifiers along with other proposed classifiers.

Pattern detection and classification of cervical cell dysplasia can assist with diagnosis and treatment. This study aims to develop a computational model for real-world applications for cervical dysplasia that has the highest degree of accuracy and the lowest computation time. Initially, an ML framework is created, which has been trained and evaluated to classify dysplasia. Three different color models, three multi-resolution transform-based techniques for feature extraction (each with different filters), two feature representation schemes, and two well-known classification approaches are developed in conjunction to determine the optimal combination of “transform (filter) ⇒ color model ⇒ feature representation ⇒ classifier”. Extensive evaluations of two datasets, one is indigenous (own generated database) and the other is publicly available, demonstrated that the Non-subsampled Contourlet Transform (NSCT) feature-based classification performs well, it reveals that the combination “NSCT (pyrexc,pkva), YCbCr, MLP” gives most satisfactory framework with a classification accuracy of 98.02% (average) using the F1 feature set. Compared to two other approaches, our proposed model yields the most satisfying results, with an accuracy in the range of 98.00–99.50%.