In recent decades, THz metamaterials have emerged as a promising technology for biosensing by extracting useful information (composition, structure and dynamics) of biological samples from the interaction between the THz wave and the biological samples. Advantages of biosensing with THz metamaterials include label-free and non-invasive detection with high sensitivity. In this review, we first summarize different THz sensing principles modulated by the metamaterial for bio-analyte detection. Then, we compare various resonance modes induced in the THz range for biosensing enhancement. In addition, non-conventional materials used in the THz metamaterial to improve the biosensing performance are evaluated. We categorize and review different types of bio-analyte detection using THz metamaterials. Finally, we discuss the future perspective of THz metamaterial in biosensing.

In this paper, we demonstrate an active metamaterial manifesting electromagnetically induced transparency (EIT) effect in the microwave regime. The metamaterial unit cell consists of a double-cross structure, between which a varactor diode is integrated. The capacitance of the diode is controlled by a reversed electrical bias voltage supplied through two connected strip lines. The diode behaves as a radiative resonant mode and the strip lines as a non-radiative resonant mode. The two modes destructively interference with each other through conductive coupling, which leads to a transmission peak in EIT effect. Through electrical control of the diode capacitance, the transmission peak frequency is shifted from 7.4 GHz to 8.7 GHz, and the peak-to-dip ratio is tuned from 1.02 to 1.66, demonstrating a significant tunability.

In this paper, we demonstrate a multi-functional metasurface for microwave beam-shaping application. The metasurface consists of an array of programmable unit cells, and each unit cell is integrated with one varactor diode. By turning the electrical bias on the diode on and off, the phase delay of the microwave reflected by the metasurface can be switched between 0 and π at a 6.2 GHz frequency, which makes the metasurface 1-bit-coded. By programming the 1-bit-coded metasurface, the generation of a single-focus beam, a double-focus beam and a focused vortex beam was experimentally demonstrated. Furthermore, the single-focus beam with tunable focal lengths of 54 mm, 103 mm and 152 mm was experimentally observed at 5.7 GHz. The proposed programmable metasurface manifests robust and flexible beam-shaping ability which allows its application to microwave imaging, information transmission and sensing applications.