In recent times, deep learning has emerged as a great resource to help research in medical sciences. A lot of work has been done with the help of computer science to expose and predict different diseases in human beings. This research uses the Deep Learning algorithm Convolutional Neural Network (CNN) to detect a Lung Nodule, which can be cancerous, from different CT Scan images given to the model. For this work, an Ensemble approach has been developed to address the issue of Lung Nodule Detection. Instead of using only one Deep Learning model, we combined the performance of two or more CNNs so they could perform and predict the outcome with more accuracy. The LUNA 16 Grand challenge dataset has been utilized, which is available online on their website. The dataset consists of a CT scan with annotations that better understand the data and information about each CT scan. Deep Learning works the same way our brain neurons work; therefore, deep learning is based on Artificial Neural Networks. An extensive CT scan dataset is collected to train the deep learning model. CNNs are prepared using the data set to classify cancerous and non-cancerous images. A set of training, validation, and testing datasets is developed, which is used by our Deep Ensemble 2D CNN. Deep Ensemble 2D CNN consists of three different CNNs with different layers, kernels, and pooling techniques. Our Deep Ensemble 2D CNN gave us a great result with 95% combined accuracy, which is higher than the baseline method.

Machine learning and deep learning algorithms are widely used in computer science domains. These algorithms are mostly used for classification and regression problems in almost every field of life. Semantic segmentation is an instantly growing research topic in the last few decades that refers to the association of each pixel in the image to the class it belongs. This paper illustrates the systematic survey of advanced research in the field of semantic segmentation till date. This study provides the brief knowledge about the latest proposed methods in the domain of semantic segmentation. The proposed study comprehends the concepts, techniques, tool, and results of different research frameworks proposed in the context of semantic segmentation. This study discusses the latest research papers in which machine learning and deep learning techniques are exploited for semantic segmentation and published between 2016 and 2021. The systematic literature review collected from seven different article libraries including ACM digital Library, Google Scholar, IEEE Xplore, Science Direct, Google Books, Refseek and Worldwide Science. For assuring the quality of the paper those papers are selected which have several citations on standardized platforms. Most of the studies used COCO, PASCAL, Cityscapes and CamVid dataset for training and validation of the machine learning and deep learning models. The results of the selected research articles are collected in the form of accuracy, mIoU value, F1 score, precision, and recall. In this study, we also conclude that most of the semantic segmentation studies use ResNet as the backbone of the architecture and none of the researchers used ensemble learning methods for semantic segmentation that is the loophole of the selected studies.

Glutamic acid is an alpha-amino acid used by all living beings in protein biosynthesis. One of the important glutamic acid modifications is post-translationally modified 4-carboxyglutamate. It has a significant role in blood coagulation. 4-carboxyglumates are required for the binding of calcium ions. On the contrary, this modification can also cause different diseases such as bone resorption, osteoporosis, papilloma, and plaque atherosclerosis. Considering its importance, it is necessary to predict the occurrence of glutamic acid carboxylation in amino acid stretches. As there is no computational based prediction model available to identify 4-carboxyglutamate modification, this study is, therefore, designed to predict 4-carboxyglutamate sites with a less computational cost. A machine learning model is devised with a Multilayered Perceptron (MLP) classifier using Chou’s 5-step rule. It may help in learning statistical moments and based on this learning, the prediction is to be made accurately either it is 4-carboxyglutamate residue site or detected residue site having no 4-carboxyglutamate. Prediction accuracy of the proposed model is 94% using an independent set test, while obtained prediction accuracy is 99% by self-consistency tests.

Cardiovascular disease (CVD) is rising as a significant concern for the healthcare sector around the world. Researchers have applied multiple traditional approaches to making healthcare systems find new solutions for the CVD concern. Artificial Intelligence (AI) and blockchain are emerging approaches that may be integrated into the healthcare sector to help responsible and secure decision-making in dealing with CVD concerns. Secure CVD information is needed while dealing with confidential patient healthcare data, especially with a decentralized blockchain technology (BCT) system that requires strong encryption. However, AI and blockchain-empowered approaches could make people trust the healthcare sector, mainly in diagnosing areas like cardiovascular care. This research proposed an explainable AI (XAI) approach entangled with BCT that enhances healthcare interpretability and responsibility to cardiovascular health medical experts. XAI is significant in addressing cardiovascular prediction issues and offers potential solutions for complex communication and decision-making in cardiovascular care. The proposed approach performs better, with the highest accuracy of 97.12% compared to earlier methods. This achievement shows its ability to tackle complex issues, accessible during healthcare sector communication and decision processes.

Drug-to-drug interaction (DDIs) occurs when a patient consumes multiple drugs. Therefore, it is possible that any medication can influence other drugs’ effectiveness. The drug-to-drug interactions are detected based on the interactions of chemical substructures, targets, pathways, and enzymes; therefore, machine learning (ML) and deep learning (DL) techniques are used to find the associated DDI events. The DL model, i.e., Convolutional Neural Network (CNN), is used to analyze the DDI. DDI is based on the 65 different drug-associated events, which is present in the drug bank database. Our model uses the inputs, which are chemical structures (i.e., smiles of drugs), enzymes, pathways, and the target of the drug. Therefore, for the multi-model CNN, we use several layers, activation functions, and features of drugs to achieve better accuracy as compared to traditional prediction algorithms. We perform different experiments on various hyperparameters. We have also carried out experiments on various iterations of drug features in different sets. Our Multi-Modal Convolutional Neural Network - Drug to Drug Interaction (MCNN-DDI) model achieved an accuracy of 90.00% and an AUPR of 94.78%. The results showed that a combination of the drug’s features (i.e., chemical substructure, target, and enzyme) performs better in DDIs-associated events prediction than other features.

Internet of Things (IoT) performs a vital role in providing connectivity between computing devices, processes, and things. It significantly increases the communication facilities and giving up-to-date information to distributed networks. On the other hand, the techniques of artificial intelligence offer numerous and valuable services in emerging fields. An IoT-based healthcare solution facilitates patients, hospitals, and professionals to observe real-time and critical data. In the literature, most of the solution suffers from data intermission, high ethical standards, and trustworthiness communication. Moreover, network interruption with recurrent expose of sensitive and personal health data decreases the reliance on network systems. Therefore, this paper intends to propose an IoT solution for AI-enabled privacy-preserving with big data transferring using blockchain. Firstly, the proposed algorithm uses a graph-modeling to develop a scalable and reliable system for gathering and transmitting data. In addition, it extracts the subset of nodes using the artificial intelligence approach and achieves efficient services for the healthcare system. Secondly, symmetric-based digital certificates are utilized to offer authentic and confidential transmission with communication resources using blockchain. The proposed algorithm is explored with existing solutions through multiple simulations and proved improvement in terms of realistic parameters.