An extended multiscale model is introduced for studying the formation of platelet thrombi in blood vessels. The model describes the interplay between viscous, incompressible blood plasma, activated and non-activated platelets, as well as other blood cells, activating chemicals, fibrinogen and vessel walls. The macroscale dynamics of the blood flow is represented by the continuous submodel in the form of the Navier–Stokes equations. The microscale cell-cell interactions are described by the stochastic Cellular Potts Model (CPM). Simulations indicate that increase in flow rates leads to greater structural heterogeneity of the clot. As heterogeneous structural domains within the clot affect thrombus stability, understanding the factors influencing thrombus structure is of significant biomedical importance.

Divergence-Free WENO Reconstruction-Based Finite Volume Scheme for Solving Ideal MHD Equations on Triangular Meshes - Volume 19 Issue 4 - Zhiliang Xu, Dinshaw S. Balsara, Huijing Du

Communications in Computational Physics (CiCP) publishes original research and survey papers of high scientific value in computational modeling of physical problems. Results in multi-physics and multi-scale innovative computational methods and modeling in all physical sciences will be featured. CiCP is a refereed, interdisciplinary journal edited by a group of world-wide leading scientists in diverse fields to guarantee its highest standard. The journal is published in a timely fashion in printed and electronic forms.