Dr. Dr. Vijayakumar Subramaniyan
Botany, AVVM Sri Pushpam College (Autonomous), Poondi, Thanjavur, Thanjavur, India
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Academic Career Length
13Years (2014-Present)
(Calculated once Scilit publication data is synced: current year − year of first publication + 1)
Representative Publications
View All Publications1 July 2014 in Journal of Ethnopharmacology
Journal Article
JYJ.E. Morvin Yabesh
J.E. Morvin Yabesh
SPS. Prabhu
S. Prabhu
Dr. Vijayakumar Subramaniyan1 April 2018 in Journal of Pharmaceutical Analysis
Journal Article
PSPrabhu Srinivasan
Prabhu Srinivasan
Dr. Vijayakumar SubramaniyanSKSwaminathan Kothandaraman
Swaminathan Kothandaraman
MPManogar Palani
Manogar Palani
In this study, molecular interactions of the ligands, quercetin, gallic acid, and metformin with various diabetes mellitus-related protein targets, such as glycogen phosphorylase and peroxisome proliferator-activated receptor gamma, were assessed. It was revealed that quercetin possesses good binding affinity to both targets. Quercetin is a major constituent of methanolic extracts of Phyllanthus emblica fruit. The antihyperglycemic effect of quercetin in streptozotocin (STZ)-induced diabetic rats was examined. The isolated quercetin administered at a dose of 75 mg/kg body weight produced a maximum decrease of 14.78% in blood glucose levels in the diabetic rats after 7 days of treatment. Furthermore, quercetin doses of 50 and 75 mg/kg were shown to significantly improve the profiles of triglycerides, high-density lipoprotein, very-low-density lipoprotein, low-density lipoprotein, and total cholesterol at the end of the study in STZ-induced diabetic rats. The administration of quercetin (25, 50, and 75 mg/kg body weight) daily for 28 days in STZ-induced diabetic rats resulted in a significant decrease in blood glucose and urine sugar levels, with a considerable rise in plasma insulin and hemoglobin levels. Therefore, quercetin is a potential drug with antidiabetic and antihyperglycemic action mediated by changes in the levels of glucose, cholesterol, and triglycerides as indicated by in silico and in vivo studies.
1 March 2018 in Microbial Pathogenesis
Journal Article
Dr. Vijayakumar SubramaniyanCKC. Krishnakumar
C. Krishnakumar
PAP. Arulmozhi
P. Arulmozhi
SMS. Mahadevan
S. Mahadevan
NPN. Parameswari
N. Parameswari
1 February 2015 in Journal of Ethnopharmacology
Journal Article
Dr. Vijayakumar SubramaniyanJYJ.E. Morvin Yabesh
J.E. Morvin Yabesh
SPS. Prabhu
S. Prabhu
RMR. Manikandan
R. Manikandan
BMB. Muralidharan
B. Muralidharan
1 October 2018 in Microbial Pathogenesis
Journal Article
PAP. Arulmozhi
P. Arulmozhi
Dr. Vijayakumar SubramaniyanTKT. Kumar
T. Kumar
1 December 2018 in Journal of Pharmaceutical Analysis
Journal Article
Dr. Vijayakumar SubramaniyanPMPalani Manogar
Palani Manogar
SPSrinivasan Prabhu
Srinivasan Prabhu
SSSanjeev Kumar Singh
Sanjeev Kumar SinghAcetylcholinesterase (AChE) plays an important role in Alzheimer's disease (AD). The excessive activity of AChE causes various neuronal problems, particularly dementia and neuronal cell deaths. Generally, anti-AChE drugs induce some serious neuronal side effects in humans. Therefore, this study sought to identify alternative drug molecules from natural products with fewer side effects than those of conventional drugs for treating AD. To achieve this, we developed computational methods for predicting drug and target binding affinities using the Schrodinger suite. The target and ligand molecules were retrieved from established databases. The target enzyme has 539 amino acid residues in its sequence alignment. Ligand molecules of 20 bioactive molecules were obtained from different kinds of plants, after which we performed critical analyses such as molecular docking; molecular dynamic (MD) simulations; and absorption, distribution, metabolism, and excretion (ADME) analysis. In the docking studies, the natural compound rutin showed a superior docking score of -12.335 with a good binding energy value of -73.313 kcal/mol. Based on these findings, rutin and the target complex was used to perform MD simulations to analyze rutin stability at 30 ns. In conclusion, our study demonstrates that rutin is a superior drug candidate for AD. Therefore, we propose that this molecule is worth further investigation using in vitro studies.
About Me
Subramaniyan Vijayakumar has received his doctorate degree from Barathidhasan University and has more than 18 years of teaching experience at U.G. and P.G. levels, and a research experience of 20 years. He is working as Assistant Professor in the Department of Botany and Microbiology, A.V.V.M. Sri Pushpam College (Autonomous), Poondi-613 503, Thanjavur district, Tamil Nadu. He has vast experience in research especially on algae, medicinal plants, environmental microbiology and computer aided drug design (CADD). He has guided many P.G. students for their projects in the field of fresh water algae, medicinal plants and bioremediation. At present, he has completed 15 Ph.D and is guiding 7 Ph.D. programmes in this line. So far, he has guided 27 M.Phil. candidates for their degree and published 136 research papers in SCI journals. He has received the best paper award from the National Symposium on “Algae, Man and Biosphere” and International Medicinal Plants and Pharmacological Research, Colombo University, Srilanka, a young scientist award from Washington University, USA, an innovative research award from Rajiv Gandhi Research centre, Mauritius, best chairperson award from the University of Malaya, and a Malaysia and best publication award from the Materials Science Research Association of China. He also completed one UGC Minor, UGC Major Project and DST-SERB major project in the area of Computer Aided Drug Design and Modelling.