Fabrizio Zaccheo

Dr. Fabrizio Zaccheo

Oral and Maxillofacial Sciences, Sapienza University of Rome, Rome, Lazio, Italy
orcid

Research Focus & Metrics

Academic Career Length

5Years (2022-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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8 August 2022 in Anatomia
Verified
Journal Article
Open access
PDF file
LSLaura Sferlazza
Laura Sferlazza
FZFabrizio Zaccheo
Fabrizio Zaccheo
MCMaria Elisabetta Camoogrande
Maria Elisabetta Camoogrande
GPGiulia Petroni
Giulia Petroni
ACAndrea Cicconetti
Andrea Cicconetti
(1) Background: The anatomical variations of neurovascular canals that are encountered in oral surgery are often overlooked by anatomy textbooks or provided with insufficient information. The aim of this study is to analyze the most common variations, describing their morphology, prevalence and clinical implications. (2) Methods: A review of published literature from the 20th century onwards was performed using the PubMed electronic database as well as anatomical textbooks. The variations being investigated were: retromolar canal (RMC) and foramen (RMF), accessory mental foramen (AMF), midline (MLF) and lateral (MLF) lingual foramina and canalis sinuosus (CS). (3) Results: Anatomical variants of neurovascular canals and foramina have a significant incidence and important clinical implications in the most common oral surgery procedures such as third molar extraction, bone harvesting and implantology. (4) Conclusions: Knowledge of these variables is highly important both for students to have a more accurate anatomical awareness and for professional surgeons to be able to provide better diagnoses and prevent complications during oral surgery techniques.

10 April 2023 in Applied Sciences
Verified
Journal Article
Open access
PDF file
FZFabrizio Zaccheo
Fabrizio Zaccheo
GPGiulia Petroni
Giulia Petroni
AGAlessandro Guttadauro
Alessandro Guttadauro
APAlfredo Passaretti
Alfredo Passaretti
MCMaria Elisabetta Camoogrande
Maria Elisabetta Camoogrande
ACAndrea Cicconetti
Andrea Cicconetti
Background: The aim of this study was to identify variations in the origins of the anterior branches of the external carotid artery (ECA) and to propose an update of the current classification. Methods: The study included 100 carotids arteries from fifty human donors. Classification of anterior branches of external carotid artery was performed according to Vaz’quez et al. (2009). Results: The configuration origins of anterior branches were found as follows: Type I, 82%; Type II, 1%; Type III, 16%. No Type IV was observed. The study identified seven subgroups of anterior branch variations in the external carotid artery. The most frequently observed variations were Subtype Ia in 40% (n = 20) of cases on the right side and Subtype Ib in 38% (n = 19) on the left side. In addition, a rare and previously unclassified configuration was observed in a 72-year-old male donor, where the carotid artery was pentafurcated on the left side. Conclusions: In conclusion, the presence of anatomical variants not previously included in the anterior external carotid artery branching classifications supports the consideration of a revision to the present classification system.

1 December 2022 in Anatomia
Verified
Journal Article
Open access
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FZFabrizio Zaccheo
Fabrizio Zaccheo
FMFrancesco Mariotti
Francesco Mariotti
AGAlessandro Guttadauro
Alessandro Guttadauro
APAlfredo Passaretti
Alfredo Passaretti
MCMaria Elisabetta Camoogrande
Maria Elisabetta Camoogrande
ACAndrea Cicconetti
Andrea Cicconetti
Detailed knowledge about the normal anatomy and its variations is a necessity in good clinical and surgical practice. The case we are reporting here shows a rare configuration origin of the superior thyroid, lingual and facial arteries arising directly from a pentafurcated common carotid artery. A fresh frozen latex-infiltrated cadaver was dissected. The superior thyroid artery, the lingual artery and the facial artery were found to be directly detached from the common carotid artery as terminations of the five terminal rami variations. The current classifications of anatomical variants are discussed in detail in relation to this case.

27 August 2024 in Applied Sciences
Verified
Journal Article
Open access
PDF file
GPGiulia Petroni
Giulia Petroni
FZFabrizio Zaccheo
Fabrizio Zaccheo
CGCira Rosaria Tiziana Di Gioia
Cira Rosaria Tiziana Di Gioia
FAFlavia Adotti
Flavia Adotti
ACAndrea Cicconetti
Andrea Cicconetti
The objective of this study is to present an uncommon case of adenomatoid odontogenic tumor (AOT) with an impacted maxillary canine, initially mimicking a follicular cyst. AOT is a rare odontogenic tumor, accounting for approximately 1% to 9% of all odontogenic tumors. It primarily occurs in the maxilla and is often associated with an unerupted permanent tooth. Follicular cysts, also known as dentigerous cysts, are benign odontogenic cysts that encase the crown of an unerupted or impacted tooth. We describe a case of AOT occurring in a 14-year-old male. Both the follicular cyst and adenomatoid odontogenic tumor (AOT) can exhibit similar clinical and radiographic presentations. It is crucial to accurately differentiate between the two to ensure appropriate treatment and prognosis.

31 March 2025 in Dentistry Journal
Verified
Journal Article
Open access
PDF file
FZFabrizio Zaccheo
Fabrizio Zaccheo
GPGiulia Petroni
Giulia Petroni
Marco TallaricoMarco Tallarico
Marco Tallarico
CGCherana Gioga
Cherana Gioga
RCRaffaella Carletti
Raffaella Carletti
ACAndrea Cicconetti
Andrea Cicconetti
Objectives: This study aimed to histologically evaluate, in humans, the orientation of collagen fibers around screw-less, Morse taper, hemispherical base abutments. Methods: This study was designed as an observational, case–control, clinical trial to evaluate the histological orientation of collagen fibers around implants. Biopsies of the peri-implant tissue were performed 8 (group A, control) or 16 (group B, test) weeks of implant uncovering, and histologically analyzed under optical microscope using Hematoxylin and Eosin, Masson, and Picro Sirius histochemical staining and a scanning electron microscope. Results: Eight patients were enrolled in this study and 16 biopsies were performed. All the biopsies were correctly analyzed. The histological examination of cross-sectional portions of the tissue taken 8 weeks after implant uncovering showed the almost complete absence of epithelial lining, while the connective tissue bundles in the superficial portion showed a lower circular pattern. The histochemical cross-section examination of the tissue taken 16 weeks after implant uncovering showed the partial presence of non-keratinizing epithelial lining at the implant site and the collagen bundles showed a greater organization, with a circumferential course around the abutment. At 8 weeks, the final histological analysis showed an average height of 1.01 mm for the keratinized epithelium, 0.83 mm for the non-keratinized epithelium, and 1.39 mm for the connective tissue. While, at 16 weeks, the values were 1.20 mm, 0.48 mm, and 1.11 mm, respectively. No statistically significant differences were found between the groups (p > 0.05). Conclusions: Histologically, there were not any differences in the height and profile of the gingiva between 8 and 16 weeks of healing after prosthesis delivery. Greater organization of the collagen fibers with a circumferential course around the abutment was found in the test group (16 weeks) compared with the control group (8 weeks).

2 December 2025 in Applied Sciences
Verified
Journal Article
Open access
PDF file
FZFabrizio Zaccheo
Fabrizio Zaccheo
GPGiulia Petroni
Giulia Petroni
ACAndrea Cicconetti
Andrea Cicconetti
Background: Mandibular third molars (MTMs) are the most frequently impacted teeth and a common indication for oral surgery. Anatomical root variations can complicate extractions and increase intra- and postoperative risks. Methods: This narrative review analyzes the most frequent MTM root anomalies—supernumerary roots, fusion, taurodontism, C-shaped canals, hypercementosis, and apical dilacerations—focusing on their clinical implications and the diagnostic role of cone-beam computed tomography (CBCT). Results: Root anomalies markedly influence surgical complexity. Supernumerary roots and fusions may hinder elevator use and require modified sectioning. Taurodontism and hypercementosis prolong procedures and increase incomplete extraction risk. C-shaped canals and severe apical curvatures raise the likelihood of root fracture, displacement, or nerve injury. Panoramic radiographs, though common, provide limited two-dimensional detail and may underestimate anomalies. CBCT, by contrast, offers three-dimensional visualization, enhancing diagnosis, planning, and safety. Conclusions: Knowledge of MTM root anomalies, combined with selective CBCT use, is essential for optimizing surgical strategies, minimizing complications, and improving outcomes.