Riccardo Manfredi

Dr. Riccardo Manfredi

1. Department of Radiology, Fondazione Policlinico Universitario Agostino Gemelli – IRCCS, Largo Agostino Gemelli 8, 00168 Rome, Italy
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Research Focus & Metrics

Academic Career Length

19Years (2008-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 November 2018 in International Journal of Radiation Oncology, Biology, Physics
Verified
Journal Article
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Nicola DinapoliNicola Dinapoli
Nicola Dinapoli
BBBrunella Barbaro
Brunella Barbaro
RGRoberto Gatta
Roberto Gatta
GCGiuditta Chiloiro
Giuditta Chiloiro
Calogero CasàCalogero Casà
Calogero Casà
VVVincenzo Valentini
Vincenzo Valentini

12 May 2021 in La radiologia medica
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Journal Article
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MBMaria Gabriella Brizi
Maria Gabriella Brizi
FPFederica Perillo
Federica Perillo
FCFederico Cannone
Federico Cannone
LTLaura Tuzza
Laura Tuzza
RMRiccardo Manfredi
Riccardo Manfredi
Acute pancreatitis is one of the most commonly encountered etiologies in the emergency setting, with a broad spectrum of findings that varies in severity from mild interstitial pancreas to severe forms with significant local and systemic complications that are associated with a substantial degree of morbidity and mortality. In this article the radiological aspect of the terminology and classification of acute pancreatitis are reviewed. The roles of ultrasound, computed tomography, and magnetic resonance imaging in the diagnosis and evaluation of acute pancreatitis and its complications are discussed. The authors present a practical image-rich guide, applying the revised Atlanta classification system, with the goal of facilitating radiologists to write a correct report, and reinforcing the radiologist’s role as a key member of a multidisciplinary team in treating patients with acute pancreatitis. Computed tomography is the most performed imaging test for acute pancreatitis. Nevertheless, MRI is useful in many specific situations, due to its superiority soft tissue contrast resolution and better assessment of biliary and pancreatic duct, for example in the ductal disconnection. The purpose if this article is to review recent advances in imaging acquisition and analytic techniques in the evaluation of AP.

31 May 2022 in Cancers
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Journal Article
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GAGiacomo Avesani
Giacomo Avesani
HTHuong Elena Tran
Huong Elena Tran
GCGiulio Cammarata
Giulio Cammarata
FBFrancesca Botta
Francesca Botta
SRSara Raimondi
Sara Raimondi
RMRiccardo Manfredi
Riccardo Manfredi
Purpose: Build predictive radiomic models for early relapse and BRCA mutation based on a multicentric database of high-grade serous ovarian cancer (HGSOC) and validate them in a test set coming from different institutions. Methods: Preoperative CTs of patients with HGSOC treated at four referral centers were retrospectively acquired and manually segmented. Hand-crafted features and deep radiomics features were extracted respectively by dedicated software (MODDICOM) and a dedicated convolutional neural network (CNN). Features were selected with and without prior harmonization (ComBat harmonization), and models were built using different machine learning algorithms, including clinical variables. Results: We included 218 patients. Radiomic models showed low performance in predicting both BRCA mutation (AUC in test set between 0.46 and 0.59) and 1-year relapse (AUC in test set between 0.46 and 0.56); deep learning models demonstrated similar results (AUC in the test of 0.48 for BRCA and 0.50 for relapse). The inclusion of clinical variables improved the performance of the radiomic models to predict BRCA mutation (AUC in the test set of 0.74). Conclusions: In our multicentric dataset, representative of a real-life clinical scenario, we could not find a good radiomic predicting model for PFS and BRCA mutational status, with both traditional radiomics and deep learning, but the combination of clinical and radiomic models improved model performance for the prediction of BRCA mutation. These findings highlight the need for standardization through the whole radiomic pipelines and robust multicentric external validations of results.

1 May 2021 in American Journal of Roentgenology
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Journal Article
Closed access
JSJordan Swensson
Jordan Swensson
AZAtif Zaheer
Atif Zaheer
DCDarwin Conwell
Darwin Conwell
KSKumar Sandrasegaran
Kumar Sandrasegaran
RMRiccardo Manfredi
Riccardo Manfredi
TTTemel Tirkes
Temel Tirkes
Secretin-enhanced MRCP (S-MRCP) has advantages over standard MRCP for imaging of the pancreaticobiliary tree. Through the use of secretin to induce fluid production from the pancreas and leveraging...

28 October 2019 in Sensors
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Journal Article
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FVFilippo Vurro
Filippo Vurro
MIchela JanniMIchela Janni
MIchela Janni
NCNicola Coppedè
Nicola Coppedè
FGFrancesco Gentile
Francesco Gentile
RMRiccardo Manfredi
Riccardo Manfredi
AZAndrea Zappettini
Andrea Zappettini
Environment, biodiversity and ecosystem services are essential to ensure food security and nutrition. Managing natural resources and mainstreaming biodiversity across agriculture sectors are keys towards a sustainable agriculture focused on resource efficiency. Vapour Pressure Deficit (VPD) is considered the main driving force of water movements in the plant vascular system, however the tools available to monitor this parameter are usually based on environmental monitoring. The driving motif of this paper is the development of an in-vivo sensor to monitor the effects of VPD changes in the plant. We have used an in vivo sensor, termed “bioristor”, to continuously monitor the changes occurring in the sap ion’s status when plants experience different VPD conditions and we observed a specific R (sensor response) trend in response to VPD. The possibility to directly monitor the physiological changes occurring in the plant in different VPD conditions, can be used to increase efficiency of the water management in controlled conditions thus achieving a more sustainable use of natural resources.

24 March 2022 in La radiologia medica
Verified
Journal Article
Open access
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RARosa Autorino
Rosa Autorino
BGBenedetta Gui
Benedetta Gui
GPGiulia Panza
Giulia Panza
LBLuca Boldrini
Luca Boldrini
DCDavide Cusumano
Davide Cusumano
RMRiccardo Manfredi
Riccardo Manfredi
Purpose: The aim of this study is to determine if radiomics features extracted from staging magnetic resonance (MR) images could predict 2-year long-term clinical outcome in patients with locally advanced cervical cancer (LACC) after neoadjuvant chemoradiotherapy (NACRT). Materials and methods: We retrospectively enrolled patients with LACC diagnosis who underwent NACRT followed by radical surgery in two different institutions. Radiomics features were extracted from pre-treatment 1.5 T T2w MR images. The predictive performance of each feature was quantified in terms of Wilcoxon–Mann–Whitney test. Among the significant features, Pearson correlation coefficient (PCC) was calculated to quantify the correlation among the different predictors. A logistic regression model was calculated considering the two most significant features at the univariate analysis showing the lowest PCC value. The predictive performance of the model created was quantified out using the area under the receiver operating characteristic curve (AUC). Results: A total of 175 patients were retrospectively enrolled (142 for the training cohort and 33 for the validation one). 1896 radiomic feature were extracted, 91 of which showed significance (p < 0.05) at the univariate analysis. The radiomic model showing the highest predictive value combined the features calculated starting from the gray level co-occurrence-based features. This model achieved an AUC of 0.73 in the training set and 0.91 in the validation set. Conclusions: The proposed radiomic model showed promising performances in predicting 2-year overall survival before NACRT. Nevertheless, the observed results should be tested in larger studies with consistent external validation cohorts, to confirm their potential clinical use.