Human retroelements (HERVs) are retroviral origin sequences fixed in the human genome. HERVs induction is associated with neurogenesis, cellular development, immune activation, and neurological disorders. Arboviruses are often associated with the development of encephalitis. The interplay between these viruses and HERVs has not been fully elucidated. In this work, we analyzed RNAseq data derived from infected human primary astrocytes by Zika (ZikV), Mayaro (MayV), Oropouche (OroV) and Chikungunya (ChikV) viruses, and evaluated the modulation of HERVs and their nearby genes. Our data show common HERVs expression modulation by both alphaviruses, suggesting conserved evolutionary routes of transcription regulation. A total of 15 HERVs were co-modulated by the four arboviruses, including the highly upregulated HERV4_4q22. Data on the upregulation of genes nearby to these elements in ChikV, MayV and OroV infections were also obtained, and interaction networks were built. The upregulation of 14 genes common among all viruses was observed in the networks, and 93 genes between MayV and ChikV. These genes are related to cellular processes such as cellular replication, cytoskeleton, cell vesicle traffic and antiviral response. Together, our results support the role of HERVs induction in the transcription regulation process of genes during arboviral infections.

A prática de hortas de agricultura natural nas escolas, conforme o conceito de Mokichi Okada, é uma abordagem eficaz para promover a educação ambiental, a alimentação saudável e o desenvolvimento integral dos estudantes. Este trabalho propõe-se a destacar os benefícios dessa prática, destacando a conscientização ambiental e o incentivo à alimentação sustentável. A agricultura natural de Okada enfatiza o cultivo sem produtos químicos, respeitando os ciclos naturais e promovendo uma relação harmoniosa entre ser humano e natureza. As hortas escolares oferecem um espaço para aprendizado prático sobre cultivo e ecologia e servem como ambiente para interação social e trabalho em equipe. Além disso, essas iniciativas contribuem para formar uma cultura de respeito à natureza entre as crianças, preparando-as para serem cidadãos mais conscientes. A revisão conclui que as hortas de agricultura natural são ferramentas valiosas no contexto educacional, proporcionando benefícios que vão além do cultivo de alimentos.