Background/Objectives: Rotator cuff (RC) tears are a leading cause of shoulder pain and disability. Artificial intelligence (AI)-based chatbots are increasingly applied in healthcare for diagnostic support and patient education, but the reliability, quality, and readability of their outputs remain uncertain. International guidelines (AMA, NIH, European health communication frameworks) recommend that patient materials be written at a 6th–8th grade reading level, yet most online and AI-generated content exceeds this threshold. Methods: We compared responses from three AI chatbots—ChatGPT-4o (OpenAI), Gemini 1.5 Flash (Google), and DeepSeek-V3 (Deepseek AI)—to 20 frequently asked patient questions about RC tears. Four orthopedic surgeons independently rated reliability and usefulness (7-point Likert) and overall quality (5-point Global Quality Scale). Readability was assessed using six validated indices. Statistical analysis included Kruskal–Wallis and ANOVA with Bonferroni correction; inter-rater agreement was measured using intraclass correlation coefficients (ICCs). Results: Inter-rater reliability was good to excellent (ICC 0.726–0.900). Gemini 1.5 Flash achieved the highest reliability and quality, ChatGPT-4o performed comparably but slightly lower in diagnostic content, and DeepSeek-V3 consistently scored lowest in reliability and quality but produced the most readable text (FKGL ≈ 6.5, within the 6th–8th grade target). None of the models reached a Flesch Reading Ease (FRE) score above 60, indicating that even the most readable outputs remained more complex than plain-language standards. Conclusions: Gemini 1.5 Flash and ChatGPT-4o generated more accurate and higher-quality responses, whereas DeepSeek-V3 provided more accessible content. No single model fully balanced accuracy and readability. Clinical Implications: Hybrid use of AI platforms—leveraging high-accuracy models alongside more readable outputs, with clinician oversight—may optimize patient education by ensuring both accuracy and accessibility. Future work should assess real-world comprehension and address the legal, ethical, and generalizability challenges of AI-driven patient education.

As a two-stage surgical procedure, Masquelet's technique has been used to care for critical-size bone defects (CSD). We aimed to determine the effects of modified and altered bone cement with biological or chemical enriching agents on the progression of Masquelet's induced membrane (IM) applied to a rat femur CSD model, and to compare the histopathological, biochemical, and immunohistochemical findings of these cements to enhance IM capacity. Thirty-five male rats were included in five groups: plain polymethyl methacrylate (PMMA), estrogen-impregnated PMMA (E+PMMA), bone chip added PMMA (BC+PMMA), hydroxyapatite-coated PMMA (HA) and calcium phosphate cement (CPC). The levels of bone alkaline phosphatase (BALP), osteocalcin (OC), and tumor necrosis factor-alpha (TNF-α) were analyzed in intracardiac blood samples collected at the end of 4 weeks of the right femur CSD intervention. All IMs collected were fixed and prepared for histopathological scoring. The tissue levels of rat-specific Transforming Growth Factor-Beta (TGF-β), Runt-related Transcription Factor 2 (Runx2), and Vascular Endothelial Growth Factor (VEGF) were analyzed immunohistochemically. Serum levels of BALP and OC were significantly higher in E+PMMA and BC+PMMA groups than those of other groups (P = 0.0061 and 0.0019, respectively). In contrast, TNF-α levels of all groups with alternative bone cement significantly decreased compared to bare PMMA (P = 0.0116). Histopathological scores of E+PMMA, BC+PMMA, and CPC groups were 6.86 ± 1.57, 4.71 ± 0.76, and 6.57 ± 1.51, respectively, which were considerably higher than those of PMMA and HA groups (3.14 ± 0.70 and 1.86 ± 0.69, respectively) (P < 0.0001). Significant increases in TGF-β and VEGF expressions were observed in E+PMMA and CPC groups (P = 0.0001 and <0.0001, respectively) whereas Runx2 expression significantly increased only in the HA group compared to other groups (P < 0.0001). The modified PMMA with E and BC, and CPC as an alternative spacer resulted in a well-differentiated IM and increased IM progression by elevating BALP and OC levels in serum and by mediating expressions of TGF-β and VEGF at the tissue level. Estrogen-supplemented cement spacer has yielded promising findings between modified and alternative bone cement.

Objective: The aim of the study is to compare the effects of exercise training plus neuromuscular electrical stimulation with exercise training alone on shoulder function, pain, range of motion, and muscle strength in patients with subacromial impingement syndrome. Design: Patients were randomly divided into groups of exercise training (n = 24) and exercise training + neuromuscular electrical stimulation (n = 24). Shoulder function was evaluated with the Disabilities of the Arm, Shoulder and Hand Questionnaire, pain level was assessed with a visual analog scale, range of motion was measured with a goniometer, and muscle strength was assessed with a handheld dynamometer baseline and at the end of treatment (week 8). Results: In both groups, shoulder function, range of motion, and muscle strength (except flexion muscle strength in the exercise training group) increased, while pain decreased (P < 0.05). Compared with the exercise training group, visual analog scale–activity and visual analog scale–night decreased more, and external-rotation range of motion and whole muscle strength increased more in the exercise training + neuromuscular electrical stimulation group (P < 0.05). On the other hand, the effect sizes were medium to large for both groups. Conclusions: The addition of neuromuscular electrical stimulation treatment to exercise training did not improve shoulder function, which is the primary outcome, more than exercise training alone, but increased muscle strength and range of motion (external-rotation only) and decreased pain (activity-night), which are the secondary outcomes.