Journal of Medical Internet Research - International Scientific Journal for Medical Research, Information and Communication on the Internet #Preprint #PeerReviewMe: Warning: This is a unreviewed preprint. Readers are warned that the document has not been peer-reviewed by expert/patient reviewers or an academic editor, may contain misleading claims, and is likely to undergo changes before final publication, if accepted, or may have been rejected/withdrawn. Readers with interest and expertise are encouraged to sign up as peer-reviewer, if the paper is within an open peer-review period. Please cite this preprint only for review purposes or for grant applications and CVs (if you are the author). Background: Using a Mobile Health (mHealth) intervention, consisting of a smartphone and compatible medical device, has the potential to enhance Chronic Obstructive Pulmonary Disease (COPD) treatment outcomes while mitigating health care costs. The purpose of this study is to understand the perceptions of health care providers (HCPs) regarding the use of mHealth in COPD management. Objective: To explore the potential facilitators and barriers among HCPs regarding the use of mHealth interventions for COPD management. Methods: This is a qualitative study. Semi-structured individual interviews were conducted with 30 HCPs, including nurses, pharmacists, and physicians who work directly with COPD patients. A flexible prompts guide was used to facilitate discussions. Topics included: demographics, mHealth usage, perceptions towards challenges of mHealth adoption, factors facilitating mHealth adoption, and preferences regarding features of the mHealth intervention for COPD management. Interviews were conversational in nature and items were not asked verbatim or in the order presented. The interviews were transcribed verbatim and compared against the digital recordings to ensure the accuracy of the content. After creating a codebook for analysis, two researchers independently coded the remaining interview data using pattern coding. They discussed commonalities and differences in coding until consensus was reached. Results: A total of 30 nurses, physicians, and pharmacists participated. The main facilitators to mHealth adoption are possible health benefits for patients, ease of use, educating patients and their HCPs, credibility, and reducing the cost to the healthcare system. Alternatively, the barriers adoption are technical issues, privacy and confidentiality issues, lack of awareness, potential limited uptake from the elderly, potential limited connection between patients and HCPs, and finances. Conclusions: It is important to understand the perceptions of HCPs regarding adoption of innovative mHealth interventions for COPD management. This study identifies some potential facilitators and barriers that may inform the successful development and implementation of mHealth interventions for COPD management.