Objectives To explore genetic/genomic nursing competency and associated factors among nurses from tertiary general and specialist cancer hospitals in mainland China and compare the competencies of nurses from the two types of hospitals. Design and setting A cross-sectional survey was conducted from November 2019 to January 2020, wherein 2118 nurses were recruited from 8 tertiary general hospitals and 4 cancer hospitals in mainland China. We distributed electronic questionnaires to collect data on nurses’ demographics, work-related variables and genomic nursing competency. Participants 2118 nurses were recruited via a three-stage stratified cluster sampling method. Results More than half (59.1%, 1252/2118) of the participants reported that their curriculum included genetics/genomics content. The mean nurses’ genomic knowledge score was 8.30/12 (95% CI=8.21 to 8.39). Only 5.4% had always collected a complete family history in the past 3 months. Compared with general hospital nurses, slightly more cancer hospital nurses (75.6% vs 70.6%, p=0.010) recognised the importance of genomics, while there was no significant difference in the knowledge scores (8.38 vs 8.21, p>0.05). Gender (β=0.06, p=0.005), years of clinical nursing (β=−0.07, p=0.002), initial level of nursing education (β=0.10, p<0.001), membership of the Chinese Nursing Association (β=0.06, p=0.004), whether their curriculum included genetics/genomics content (β=0.08, p=0.001) and attitude towards becoming more educated in genetics/genomics (β=0.25, p<0.001) were significantly associated with the nurses’ genomic knowledge score. Conclusion The levels of genomic knowledge among mainland Chinese nurses in tertiary hospitals were moderate. The overall genomic competency of cancer hospital nurses was comparable to that of general hospital nurses. Further genomic training is needed for nurses in China to increase their genomic competency and accelerate the integration of genomics into nursing practice.

Background: People living with HIV/AIDS face multiple challenges that collectively impede their adaptation outcomes. These outcomes include quality of life (QoL), acceptance of illness, mental health (including symptoms of anxiety and depression), and antiretroviral therapy (ART) adherence. While existing evidence addresses specific challenges, it often overlooks the interactions among the various problems people living with HIV/AIDS encounter. The comprehensive-task disease management framework and positive self-management framework provide a theoretical basis for understanding the adaptation process. A culturally tailored, theory-based intervention may be necessary and effective in facilitating better adaptation outcomes for people living with HIV/AIDS. Objective: This study aimed to evaluate the effect of a hybrid intervention called AiCare (Adaptation intervention with Comprehensive-task disease management framework to achieve renormal life) on improving QoL, acceptance of illness, mental health (anxiety and depression), and ART adherence among people living with HIV/AIDS in China. Methods: We conducted a 2-arm randomized controlled trial, recruiting 92 people living with HIV/AIDS from an HIV clinic in Hunan, China. Participants were randomly assigned in a 1:1 ratio to either the control group (receiving standard care) or the intervention group (receiving AiCare in addition to standard care). All analyses were performed from an intention-to-treat perspective. Sociodemographic and HIV-specific clinical characteristics, along with key adaptation outcomes—including QoL, acceptance of illness, mental health (anxiety and depression), and ART adherence—were assessed at baseline (T0), post intervention (T1), and 3 months post intervention (T2). We used generalized estimating equation models and difference-in-difference analysis to evaluate the interventions’ effects. Results: The difference-in-difference model showed that at T1, the intervention group experienced significant improvements compared to the control group. QoL increased by 6.35 (95% CI 2.62-10.93, P=.001), acceptance of illness improved by 4.49 (95% CI 2.29-6.68, P<.001), and anxiety decreased by 2.15 (95% CI 1.19-3.11; P=.01). At T2, the intervention group’s improvement in QoL was not statistically significant (β 3.62, 95% CI –1.53 to 8.77; P=.17). However, acceptance of illness remained significantly improved by 3.65 (95% CI 1.22-6.08; P=.003), and anxiety decreased by 1.58 (95% CI 0.42-2.74; P=.007). No significant changes were observed in depression or ART adherence between the intervention and control groups. Feedback regarding the AiCare program indicated its acceptability and feasibility. Conclusions: The AiCare program demonstrated promising effects in improving disease adaptation outcomes among people living with HIV/AIDS, notably in enhancing QoL, fostering acceptance of illness, and mitigating anxiety symptoms. These findings underscore the hybrid program’s potential clinical utility to facilitate the adaptation of people living with HIV/AIDS. Trial Registration: Chinese Clinical Trial Registry ChiCTR2400087255; https://www.chictr.org.cn/showproj.html?proj=220729

Purpose: Undetectable = Untransmittable (U=U) is the scientific consensus that people living with HIV (PLWH) who maintain an undetectable viral load cannot sexually transmit HIV to others. This study aimed to explore the status of PLWH’s perception of U=U (including knowledge, attitude, and acceptance) and the relationships with their sexual behaviors and potential physical and psychological benefits (satisfaction of health, depression, self-stigma, quality of life, ART adherence, viral load and CD4+ cell level). Patients and Methods: We analyzed data from 730 PLWH aged 18 years or older from the outpatient clinic at the Affiliated Changsha Hospital of Xiangya School of Medicine, Central South University, between October 2021 and January 2022. Data were collected using a structured, anonymous, paper-based questionnaire. It gathered information on U=U perception, sexual risk behaviors, potential physical and psychological benefits and socio-demographic and clinical characteristics. To examine associations between U=U perception and sexual risk behaviors and potential physical and psychological benefits, for categorical outcome variable, multiple logistic regression was adopted for the CD4+ cells and HIV viral load level; for count outcome variable, generalized linear model (GLM) with Poisson regressor was used for sexual risk behaviors; and since all the other response variables were skewed, GLM with Gamma regressor was used. Results: The mean age of the participants was 33.6 years (SD = 10.8). Majority (95.1%) of the participants were male and initiated ART (97%). Nearly half had bachelor’s degree or higher (45.6%) and were identified as homosexuality (48.5%). More than half heard U=U (63.8%) and perceived U=U accurate (57.4%), however only 13.6% had a comprehensive understanding of U=U and 19.9% accepted U=U as a strategy for HIV prevention. The acceptance level of U=U was positively correlated with increased unprotected sexual behaviors [β(95% CI)=0.21(0.045,0.365); P< 0.05)]. The U=U perception was not related to depression, antiretroviral therapy adherence, self-stigma and perceived quality of life. We only found that less U=U knowledge was associated with the detectable [β(95% CI)=0.69(0.503,0.903); P< 0.05)] or unavailable viral load [β(95% CI)=0.68(0.0528,0.884); P< 0.01)], and unavailable CD4+ cell counts was more like to less U=U knowledge [β(95% CI)=0.62(0.395,0.959); P< 0.05)]. Furthermore, those with unavailable viral data exhibited a more negative attitude towards U=U [β(95% CI)=0.79(0.635,0.977); P< 0.05)]. In addition, lower level of U=U acceptance was related to the unavailable CD4 cell counts [β(95% CI)=0.67(0.474,0.940); P< 0.05)]. Conclusion: This study suggests that PLWH have not fully reaped the benefits of U=U. Further research is necessary to explore strategies for promoting clear and accurate information about U=U and for effectively communicating the personal and societal benefits of U=U to PLWH.

Purpose: in this scoping review, previously reported data were described and synthesized to document transition interventions in CCSs, and the features of intervention components of the current transition studies for CCSs were summarized. Methods: A literature search was conducted in PubMed, Web of Science, EMBASE, PsycINFO, CINAHL, Ovid, and the Cochrane Library following the PRISMA-ScR statement. All original studies (n = 9) investigating transition interventions in CCSs were included. Results: The current studies identified essential elements for transition programs, such as delivering knowledge, developing skills for coordination of care, and addressing psychosocial needs. However, the current transition interventions were generally in their infancy, and major deficits were found, including poorly reported intervention components and procedures, a limited number of relevant validated outcomes, and a failure to incorporate conceptual frameworks and international consensus statements. Conclusions: This scoping review mapped current evidence of transition interventions for CCSs and highlighted the paucity of data in this area. More high-quality and well-reported randomized controlled trials are needed for the enrichment and standardization of future transition interventions.

Introduction Fatigue is a common symptom among people living with HIV (PLWH). It has a substantial adverse impact on functional status and the ability to conduct activities of daily living. Identifying effective strategies to prevent or reduce fatigue is significant to promote the quality of life of this vulnerable population. The purpose of this review is to synthesise the non-pharmacological evidence and assess the effects of interventions on reducing HIV-related fatigue among PLWH. Methods and analysis We will comprehensively search literature available up to 30 June 2020, in the following databases: PubMed, Embase, CINAHL, Cochrane Library, Web of Science and PsycINFO. The reference list of selected studies and relevant published reviews will also be screened to retrieve potential articles. Two reviewers will identify the eligible articles, extract data and identify the biases in the selected studies. Any disagreements will be referred to a third reviewer. We will qualitatively synthesise the evidence and pool data with meta-analysis according to the heterogeneity of different studies. Ethics and dissemination This systematic review will not raise any ethical issues since it is a secondary data collection and analysis. The results will inform effective strategies to reduce fatigue among PLWH. The final report will be published in a peer-reviewed journal and academic conferences. PROSPERO registration number CRD42020153715.