Several factors may increase the risk of development of ovarian cancer. In this study, we investigated the relationship between social, genetic, and histopathologic factors in women with ovarian serous cystadenocarcinoma and titin (TTN) mutations, whether the TTN gene mutation may be a predictor, and its impact on mortality and survival in these patients. A total of 585 samples from patients with ovarian serous cystadenocarcinoma were collected from The Cancer Genome Atlas and PanCancer Atlas through the cBioPortal for analysis of social, genetic, and histopathological factors. Logistic regression was used to investigate whether TTN mutation could be a predictor, and the Kaplan–Meier method was applied to analyze survival time. TTN mutation frequency did not differ between age at diagnosis, tumor stage, and race, and was related to increased Buffa hypoxia score (p = 0.004), mutation count (p < 0.0001), Winter hypoxia Score (p = 0.030), nonsynonymous tumor mutation burden (TMB) (p < 0.0001), and reduced microsatellite instability sensor score (p = 0.010). The number of mutations (p < 0.0001) and winter hypoxia score (p = 0.008) were positively associated with TTN mutations, and nonsynonymous TMB (p < 0.0001) proved to be a predictor. Mutated TTN affects the score of genetic variables involved in cancer cell metabolism in ovarian cystadenocarcinoma.

Objetivo: Analisar as variáveis sociais, clínicas e hemodinâmicas dos pacientes internados em Unidade de Terapia Intensiva (UTI) que evoluíram com sepse. Metodologia: Estudo retrospectivo, observacional e transversal. Foram elegíveis 224 prontuários, divididos em dois grupos: sepse presente (SP) n=165 e sepse ausente (SA) n=59. Foram descritas e analisadas as variáveis sociais, clínicas e hemodinâmicas. Resultados: As variáveis que tiveram associação com a sepse foram a baixa escolaridade e o estado civil casado. Nas variáveis clínicas observou-se que pacientes que precisam de intervenções invasivas foram associadas à sepse. As variáveis hemodinâmicas PaCO2, Be, Bicarbonato, leucócitos, hemácias, uréia, sódio e potássio alterados foram associados ao quadro de sepse. Estes pacientes permaneceram maior tempo na UTI e tiveram o óbito como desfecho. Conclusão: Existem variáveis sociais, clínicas e hemodinâmicas específicas que estão relacionadas à sepse. O conhecimento destas variáveis pode direcionar para que investimentos e recursos sejam direcionados visando prevenir esta complicação clínica.