Dr. Antonio Speciale
University of Messina, Messina, Sicilia, Italy
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Academic Career Length
21Years (2006-Present)
(Calculated once Scilit publication data is synced: current year − year of first publication + 1)
Representative Publications
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Journal Article
Maria Laura IlardoAntonio SpecialeNowadays, the classic perception of the pharmaceutical profession in community pharmacies is facing worldwide extinction due to many factors. Among the numerous factors, online pharmacies are increasingly gaining ground thanks to their ability to facilitate customer demand. Nevertheless, they are endangering “face-to-face” contact, affecting the building of customer loyalty based on direct “human” interaction, and consequently reducing pharmacists to mere commercial figures. Patient-centered care communication is emphasized as the essential element to build a solid and appropriate interpersonal relationship with the patient, to make the consultancy process effective, and to strengthen the pharmacist’s professionalism in community pharmacy. This paper presents a narrative review of existing literature with the first aim of pinpointing the factors affecting pharmacy professional practice, and secondly, of how to improve patient-centered communication skills. A more widespread introduction of in-depth study and practice of behavioral, communication, educational, and sociological methodologies and techniques would allow for the development of more effective skills used for providing an efficient consultancy service, improving the capacity of future professionals to approach public relations.
1 August 2018 in Phytochemistry
Journal Article
Edoardo NapoliLSLaura Siracusa
Laura Siracusa
GRGiuseppe Ruberto
Giuseppe Ruberto
ACAlessandra Carrubba
Alessandra CarrubbaSLSilvia Lazzara
Silvia Lazzara
MCMariateresa Cristani
Mariateresa Cristani
+3
1 December 2016 in Toxicology Letters
Journal Article
DFDaniela Ferrari
Daniela FerrariAntonio SpecialeCMCristani Mariateresa
Cristani Mariateresa
Deborah FratantonioMMMaria Sofia Molonia
Maria Sofia Molonia
Francesco Cimino +2
1 December 2011 in Current Molecular Medicine
Journal Article
Antonio SpecialeJCJ. Chirafisi
J. Chirafisi
Antonina SaijaFrancesco CiminoMany plant antioxidants, intaken through the daily diet or plant-derived dietary supplements, have been shown able to prevent free radical-related diseases by counteracting cell oxidative stress. However, it is now considered that the in vivo beneficial effects of these phytochemicals are unlikely to be explained just by their antioxidant capability. Several plant antioxidants exhibit hormetic properties, by acting as ‘low-dose stressors’ that may prepare cells to resist more severe stress. In fact, low doses of these phytochemicals activate cell signaling pathways (being the most prominent examples the modulation of the Nrf2/Keap1 pathway, the NF-κB pathway and the Sirtuin-FOXO pathway) but high doses are cytotoxic. Herein we review the adaptive responses induced by the most known plant hormetic antioxidants, which are sulforaphane, resveratrol, curcumin, flavonoids, green tea catechins and diallylsulphides, as well as the molecular mechanisms involved in such responses. Furthermore, this review outlines that the hormetic properties of these bioactive plant antioxidants might be successfully employed for realizing health-promoting dietary interventions especially in the field of neurodegenerative diseases and cancer.
19 October 2010 in Journal of Agricultural and Food Chemistry
Journal Article
Antonio SpecialeRCRaffaella Canali
Raffaella CanaliJCJoselita Chirafisi
Joselita Chirafisi
Antonina Saija
Fabio VirgiliFrancesco Cimino31 July 2013 in Molecular Nutrition & Food Research
Journal Article
Antonio Speciale
Sirajudheen AnwarRCRaffaella Canali
Raffaella CanaliJCJoselita Chirafisi
Joselita Chirafisi
Antonina SaijaFrancesco Cimino +1
About Me
Dr. Antonio Speciale is Researcher (RTD-B, SSD BIO/14) at the department of Chemical, Biological, Pharmaceutical and Environmental Sciences, Università degli Studi di Messina, Italy. He received a degree in Chimica e Tecnologie Farmaceutiche in 2004, and obtained a Ph.D. in Toxicology in 2009, and a degree as Specialist in Pharmacognosy in 2013 at the University of Messina, and completed is training in the Pharmacogenetics Working Group at Virginia Commonwealth University (Richmond, VA, USA).
Dr. Speciale teaches the course of Pharmacovigilance and Pharmacoeconomics - Chemotherapy and Immunofarmacology in the Master degree in Pharmacy, and teaches the course of Evidence-Based Pharmacotherapy in the Specialization School in Hospital Pharmacy at the Università degli Studi di Messina, Italy.
His research interests are mainly focused in elucidating the mode-of-action of bioactive compounds by using in vitro cellular models. In particular, his research focuses on natural products and their capacity to modulate cellular adaptive response pathways, such as Nrf2/Keap1 pathway and NF-κB pathway, and in the discovery of natural products-based anticancer agents.
Up to November 13, 2018, as downloaded from ISI he has got 47 (51 Scopus) papers, 602 (688 Scopus, 876 Google Scholar) times cited with an Average Citation per Year of 51.92, an Average Citation per Item of 10.42 and an H-index of 15 (15 Scopus, 17 Google Scholar with i10-index of 26), with a Total Impact Factor of 140.2