Purpose: During the COVID-19 pandemic, the physical and mental health of general population has been adversely affected. This study aims to investigate if there are age-related differences in functional capacity, physical activity, life satisfaction, well-being and quality of life among adults of different age groups during this era. Methods: One-hundred fifty participants aged between 18-65 years were included. Participants were divided into 5 age groups, with 30 people in each age group i.e., 18-25, 25-35, 35-45, 45-55, and 55-65 years, using a block randomization. Functional capacity was evaluated with 1-minute sit-to-stand test (1-min STST); level of physical activity with International Physical Activity Questionnaire-Short Form (IPAQ-SF); life satisfaction with The Satisfaction with Life Scale (SWLS); well-being with WHO-5 Well-Being Index (WHO-5); and the quality of life with Short Form-12 (SF-12). All assessments were applied via an online form. Results: Age negatively correlated to 1-min STST (p<0.01, r=-0.214) and IPAQ total score (p<0.01, r=-0.173), whereas positively correlated to SWLS score (p<0.05, r=0.168) and MCS-12 score (p<0.01, r=0.339). There were statistically significant age-related differences in IPAQ total scores (p=0.001; F=5.169), MCS-12 scores (p<0.001; F=8.624) and SWLS scores (p=0.046; F=2.485). Individuals aged 18-25 years had the best IPAQ-SF score, and the worst SWLS and MCS-12 scores among other age groups. Conclusion: Younger individuals seem to have worse impairment in mental aspects of their lives compared to older counterparts, despite having relatively higher functional capacity and physical activity participation during COVID-19. These age-related differences should be taken into account when tailoring rehabilitation and/or counselling programs during this era.

Amaç: Koronavirüs 2019 (Covid-19) pandemisi, yüksek morbidite ve mortalite oranlarına neden olmaktadır. Bu çalışma, diyabetik Covid-19 hastaları (grup I), diyabetik olmayan Covid-19 hastaları (grup II) ve sağlıklı kontroller ( Grup III) arasındaki hemoglobin A1c (HbA1c), lipid profilleri, homosistein, oksidatif stres ve fiziksel aktivite düzeylerini karşılaştırmayı amaçlamaktadır. Yöntem: Katılımcıların venöz kan örneklerinden HbA1c, lipid profilleri, homosistein, oksidatif stres, oksidan ve antioksidan seviyesi analiz edildi ve Uluslararası Fiziksel Aktivite Anketi ile fiziksel aktivite seviyeleri ölçüldü. Tüm parametreler gruplar arasında karşılaştırıldı (her grup için n=16). Bulgular: Grup I'de HbA1c ve açlık kan şekeri düzeyleri grup II ve III'e göre yüksekti (p<0.001). Gruplar arasında serum total kolesterol, trigliserit, yüksek yoğunluklu lipoprotein kolesterol ve düşük yoğunluklu lipoprotein kolesterol düzeyleri arasında anlamlı fark vardı (p<0.001). Grup III ile karşılaştırıldığında grup I ve grup II'de daha düşük süperoksit dismutaz (p<0.001) ve toplam antioksidan seviyesi (TAS) (p<0.001), daha yüksek malondialdehit, total oksidan seviyesi (TOS) (p<0.001), oksidatif stres indeksi (p<0.001), C-reaktif protein seviyesi (p=0.001) ve nötrofil/lenfosit oranı (p<0.001) (p<0.001) vardı. Grup I ve II'deki hastaların fiziksel aktivite düzeyleri grup III'e göre daha düşük olmasına rağmen, yalnızca grup II'deki hastaların fiziksel aktivite düzeyleri grup III'e göre anlamlı olarak daha düşüktü (p=0,006). Sonuç: Diyabetik Covid-19 hastalarının kan şekeri belirteçleri, diyabetik olmayan Covid-19 hastalarına ve sağlıklı kontrollere göre daha yüksek olabilir. Diyabetik ve diyabetik olmayan hastalarda sağlıklı kontrollere göre daha yüksek oksidan ve daha düşük antioksidan aktiviteler, dolayısıyla daha yüksek oksidatif stres düzeyi görülebilmektedir. Ayrıca diyabetik olmayan Covid-19 hastalarının fiziksel aktivite düzeyleri, diyabetik Covid-19 hastalarına ve sağlıklı kontrollere göre daha düşük olabilir. Objective: The coronavirus disease 2019 (Covid-19) pandemic results in higher morbidity and mortality rates. This study aims to compare hemoglobin A1c (HbA1c), lipid profiles, homocysteine, oxidative stress, and physical activity levels between diabetic Covid-19 patients (group I), non-diabetic Covid-19 patients (group II), and healthy controls (group III). Method: HbA1c, lipid profiles, homocysteine, oxidative stress, oxidant, and antioxidant status were analyzed from the venous blood samples and physical activity levels were measured with International Physical Activity Questionnaire. All the parameters were compared between the groups (n=16 for each group). Results: HbA1c and fasting blood glucose levels in group I were higher than group II and III (p<0.001). There were significant differences in serum levels of total cholesterol, triglyceride, high density lipoprotein cholesterol and low-density lipoprotein cholesterol between the groups (p<0.001). There was lower superoxide dismutase and total antioxidant status (TAS), and higher malondialdehyde, total oxidant status (TOS), oxidative stress index, C-reactive protein levels (p=0.001), and neutrophil/lymphocyte ratio (p<0.001) in group I and II compared with group III (p<0.001). Although the patients in group I and II had lower physical activity levels than group III, only the patients in group II had significantly lower physical activity levels than group III (p=0.006). Conclusion: Diabetic Covid-19 patients may have higher blood glucose markers than non-diabetic Covid-19 patients and healthy controls. Higher oxidant and lower antioxidant activities, thus higher oxidative stress level could be seen in diabetic and non-diabetic patients than healthy controls. In addition, Moreover, the physical activity levels of non-diabetic Covid-19 patients may be lower than diabetic Covid-19 patients and healthy controls.