Sepsis is a clinical syndrome with high mortality and morbidity rates. In sepsis, the abrupt release of cytokines by the innate immune system may cause multiorgan failure, leading to septic shock and associated complications. In the presence of a number of systemic disorders, such as sepsis, infections, diabetes, and systemic lupus erythematosus (SLE), cardiorenal syndrome (CRS) type 5 is defined by concomitant cardiac and renal dysfunctions Thus, our study suggests that certain mRNAs and unexplored pathways may pave a way to unravel critical therapeutic targets in three debilitating and interrelated illnesses, namely, sepsis, SLE, and CRS. Sepsis, SLE, and CRS are closely interrelated complex diseases likely sharing an overlapping pathogenesis caused by erroneous gene network activities. We sought to identify the shared gene networks and the key genes for sepsis, SLE, and CRS by completing an integrative analysis. Initially, 868 DEGs were identified in 16 GSE datasets. Based on degree centrality, 27 hub genes were revealed. The gProfiler webtool was used to perform functional annotations and enriched molecular pathway analyses. Finally, core hub genes (EGR1, MMP9, and CD44) were validated using RT-PCR analysis. Our comprehensive multiplex network approach to hub gene discovery is effective, as evidenced by the findings. This work provides a novel research path for a new research direction in multi-omics biological data analysis.

Background/Objectives: Demyelination and neuroinflammation are central features of multiple sclerosis (MS), contributing to motor deficits and cognitive decline. Cuprizone (CPZ)-induced demyelination is a well-established model for studying multiple sclerosis-like neurotoxicity. This study investigated the neuroprotective and immunomodulatory effects of self-nanoemulsifying drug delivery systems (SNEDDSs) incorporating curcumin, piperine, and Zanthoxylum rhetsa seed oil. Methods: Male mice were divided into five groups: control, CPZ-only, and CPZ co-treated with three nanoformulations BFZ (blank SNEDDS), CFZ (curcumin-SNEDDS), and PFZ (curcumin–piperine SNEDDS). CPZ was administered for 5 weeks, followed by a 2-week recovery or treatment phase. Key neuroinflammatory markers like CD4, CD8, cholinergic (acetylcholinesterase, AChE), myelin integrity (MBP), BDNF, CREB, TNFα, Il-1β were assessed at weeks 5 and 7 using ELISA. Alterations in antioxidant enzymes, brain histology, and behavioral outcomes were also investigated. Results: At week 5, CPZ significantly increased CD4 and CD8 expression and reduced AChE and MBP levels, indicating neuroinflammation, cholinergic impairment, and demyelination. Nanoformulation treatments (both prophylactic and therapeutic) markedly reduced CD4 and CD8 levels, with PFZ showing the most pronounced effect. AChE activity was significantly restored in all treatment groups, with PFZ and CFZ exceeding baseline levels, suggesting enhanced cholinergic function. MBP levels were highest in PFZ-treated mice, surpassing control values and indicating strong remyelination potential. These improvements persisted and further advanced at week 7, especially in PFZ and CFZ groups. Conclusions: Curcumin-based SNEDDS, particularly PFZ, significantly mitigated CPZ-induced neuroinflammation, promoted remyelination, and restored cholinergic activity in the frontal cortex. These findings highlight the therapeutic potential of bioenhanced curcumin nanoformulations for treating demyelinating and neuroinflammatory disorders.

Far-infrared radiation (FIR), an invisible part of the electromagnetic spectrum, is recognised for its potential therapeutic effects, particularly in promoting cardiovascular health. It has been proposed that FIR therapy enhances endothelial function and reduces arterial stiffness-both key markers of cardiovascular integrity. This study aims to elucidate the underlying mechanisms by which FIR therapy influences vascular function, specifically examining its impact on redox-associated gene expression and vascular responses in healthy subjects. In this single-blinded, pilot study, 50 healthy participants were subjected to receive either FIR radiation, heat treatment or a placebo treatment to the upper back. Vascular function was assessed by measuring endothelial function using laser Doppler imaging with iontophoresis and assessing arterial stiffness via SphygmoCor. Gene expression analysis was performed on peripheral blood mononuclear cells (PBMCs), focusing on redox-associated cytoprotective genes and nitric oxide synthase (NOS). FIR radiation led to a significant enhancement in endothelial function and a reduction in arterial stiffness in healthy individuals. Gene expression analyses demonstrated an upregulation of cytoprotective genes, including NOS3, TXNRD1 and HSP70, post-FIR radiation. FIR radiation has been shown to effectively enhance vascular function by improving endothelial function and decreasing arterial stiffness, which likely occurs through activation of cytoprotective pathways. This study suggests that FIR therapy could serve as a non-invasive modality to support cardiovascular health. These results offer valuable biochemical insights into the vascular protective effects of FIR and highlight its potential as a therapeutic strategy for cardiovascular disease prevention. Aim: The primary aim of this study is to investigate the effect of localised FIR radiation on vascular function, in particular, endothelial function and arterial stiffness in healthy subjects. Endothelial function was examined using LDI combined with the iontophoresis of ACh and SNP, and using circulatory biomarkers for endothelial cells function and oxidation, while arterial stiffness was assessed through the AI@75 %. The hypothesis of this study is that FIR confers beneficial effects on endothelial function and arterial stiffness through antioxidative and anti-inflammatory mechanisms, mediated in part by the upregulation of cytoprotective genes.

Undergraduate selection, especially for medical degree programs, is a challenging and controversial matter for both national and international institutions. The importance of this paper lies in trying to identify the process of selecting prospective students for medical studies in Saudi Arabia. The currently applied admission criteria are the weighted average score (WAS) of the three pre-university attainments, the general secondary school (GSS), the general aptitude test (GAT), and the scientific achievement test (SAT). There is a different weightage assigned to WAS throughout the national medical institutions. It raises concern about the scientific rationale behind the differences. The present research correlates longitudinal school and university data of medical graduates using a robust methodology of multinomial logistic regression in an attempt to find statistically significant ratios of WAS. A quantitative critique of the admission process was conducted for relatively large 440 graduates of the six-year medicine program, enrolled in five academic years. Several scenarios of admission criteria have been investigated for their significant association and prediction of the academic and clinical performance of medical students. The findings suggest several choices of WAS according to the decision of educational policymakers. The future implications that may influence forthcoming decisions regarding selection criteria are humbly offered. Keywords: Admission test, entrance exam, medical study, logistic regression, Qiyas tests, Saudi Arabia.