Elisabeth Mechlenburg Møller

Prof. Elisabeth Mechlenburg Møller

orcid

Research Focus & Metrics

Academic Career Length

23Years (2004-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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18 July 2019 in PLOS Medicine
Verified
Journal Article
Open access
ALAntti P. Launonen
Antti P. Launonen
BSBakir O. Sumrein
Bakir O. Sumrein
ARAleksi Reito
Aleksi Reito
VLVesa Lepola
Vesa Lepola
JPJuha Paloneva
Juha Paloneva
AGas the NITEP group
as the NITEP group
Although increasingly used, the benefit of surgical treatment of displaced 2-part proximal humerus fractures has not been proven. This trial evaluates the clinical effectiveness of surgery with locking plate compared with non-operative treatment for these fractures. The NITEP group conducted a superiority, assessor-blinded, multicenter randomized trial in 6 hospitals in Finland, Estonia, Sweden, and Denmark. Eighty-eight patients aged 60 years or older with displaced (more than 1 cm or 45 degrees) 2-part surgical or anatomical neck proximal humerus fracture were randomly assigned in a 1:1 ratio to undergo either operative treatment with a locking plate or non-operative treatment. The mean age of patients was 72 years in the non-operative group and 73 years in the operative group, with a female sex distribution of 95% and 87%, respectively. Patients were recruited between February 2011 and April 2016. The primary outcome measure was Disabilities of Arm, Shoulder, and Hand (DASH) score at 2-year follow-up. Secondary outcomes included Constant-Murley score, the visual analogue scale for pain, the quality of life questionnaire 15D, EuroQol Group's 5-dimension self-reported questionnaire EQ-5D, the Oxford Shoulder Score, and complications. The mean DASH score (0 best, 100 worst) at 2 years was 18.5 points for the operative treatment group and 17.4 points for the non-operative group (mean difference 1.1 [95% CI -7.8 to 9.4], p = 0.81). At 2 years, there were no statistically or clinically significant between-group differences in any of the outcome measures. All 3 complications resulting in secondary surgery occurred in the operative group. The lack of blinding in patient-reported outcome assessment is a limitation of the study. Our assessor physiotherapists were, however, blinded. This trial found no significant difference in clinical outcomes at 2 years between surgery and non-operative treatment in patients 60 years of age or older with displaced 2-part fractures of the proximal humerus. These results suggest that the current practice of performing surgery on the majority of displaced proximal 2-part fractures of the humerus in older adults may not be beneficial. ClinicalTrials.gov NCT01246167.

25 November 2019 in Acta Orthopaedica
Verified
Journal Article
Open access
SBSara Birch
Sara Birch
Maiken StillingMaiken Stilling
Maiken Stilling
EMElisabeth Mechlenburg Møller
Elisabeth Mechlenburg Møller
THTorben Bæk Hansen
Torben Bæk Hansen
Background and purpose - Pain catastrophizing contributes to acute and long-term pain after total knee arthroplasty (TKA) but currently there are only limited treatment options. This study investigates the effectiveness of patient education in pain coping among patients with moderate to high pain catastrophizing score before TKA. Secondary outcomes were physical function, quality of life, self-efficacy, and pain catastrophizing.Patients and methods - The study was a parallel-group randomized controlled trial including patients with moderate to high levels of pain catastrophizing. 60 patients were recruited from December 2015 to June 2018. The mean age of the patients was 66 (47-82) years and 40 were women. The patients were randomized to either cognitive-behavioral therapy (CBT) based pain education or usual care. The primary outcome measure was pain under activity measured with the Visual Analog Scale (VAS). All outcomes were measured preoperatively, at 3 months, and at 1 year after surgery.Results - We found no difference in the primary outcome measure, VAS during activity, between the 2 groups but both groups had large reductions over time. The CBT-based pain education group reduced their VAS score by 37 mm (95% CI 27-46) and the control group by 40 mm (CI 31-49). We found no statistically significantly differences between the 2 groups in any of the secondary outcomes.Interpretation - Future research is warranted to identify predictors of persistent pain and interventions for the approximately 20% of patients with persisting pain after a TKA.

14 November 2016 in British Journal of Sports Medicine
Verified
Journal Article
Closed access
PDF file
SKSigne Kierkegaard
Signe Kierkegaard
MLMartin Langeskov-Christensen
Martin Langeskov-Christensen
BLBent Lund
Bent Lund
FNFlorian D Naal
Florian D Naal
EMElisabeth Mechlenburg Møller
Elisabeth Mechlenburg Møller
NCNicola Casartelli
Nicola Casartelli
Aim To investigate pain, activities of daily living (ADL) function, sport function, quality of life and satisfaction at different time points after hip arthroscopy in patients with femoroacetabular impingement (FAI). Design Systematic review with meta-analysis. Weighted mean differences between preoperative and postoperative outcomes were calculated and used for meta-analysis. Data sources EMBASE, MEDLINE, SportsDiscus, CINAHL, Cochrane Library, and PEDro. Eligibility criteria for selecting studies Studies that evaluated hip pain, ADL function, sport function and quality of life before and after hip arthroscopy and postoperative satisfaction in patients with symptomatic FAI. Results Twenty-six studies (22 case series, 3 cohort studies, 1 randomised controlled trial (RCT)) were included in the systematic review and 19 in the meta-analysis. Clinically relevant pain and ADL function improvements were first reported between 3 and 6 months, and sport function improvements between 6 months and 1 year after surgery. It is not clear when quality of life improvements were first achieved. On average, residual mild pain and ADL and sport function scores lower than their healthy counterparts were reported by patients following surgery. Postoperative patient satisfaction ranged from 68% to 100%. Conclusions On average, patients reported earlier pain and ADL function improvements, and slower sport function improvements after hip arthroscopy for FAI. However, average scores from patients indicate residual mild hip pain and/or hip function lower than their healthy counterparts after surgery. Owing to the current low level of evidence, future RCTs and cohort studies should investigate the effectiveness of hip arthroscopy in patients with FAI. Trial registration number CRD42015019649.

1 January 2009 in Acta Orthopaedica
Verified
Journal Article
Open access
ATAnders Troelsen
Anders Troelsen
EMElisabeth Mechlenburg Møller
Elisabeth Mechlenburg Møller
JGJohn Gelineck
John Gelineck
LBLars Bolvig
Lars Bolvig
SJSteffen Jacobsen
Steffen Jacobsen
KSKjeld Soballe
Kjeld Soballe
An acetabular labral tear is a diagnostic challenge. Various clinical tests have been described, but little is known about their diagnostic sensitivity and specificity. We investigated the diagnostic validity of clinical tests and ultrasound as compared with MR arthrography. We examined 18 patients (18 hips, 2 men, median age 43 (32-56) years) with impingement test, FABER test, resisted straight leg raise test, ultrasound, and MR arthrography. They had had previous periacetabular osteotomies due to symptomatic, acetabular dysplasia. All hips showed no or only slight signs of osteoarthritis (Tönnis grade 0-1). MR arthrography identified labral tears in 17 of the 18 hips. Ultrasound had a sensitivity of 94%, a positive predictive value of 94%, and was false negative in only 1 case compared to MR arthrography. The impingement test had the best diagnostic ability of the clinical tests, with a sensitivity of 59% and a specificity of 100%. The positive predictive value was 100% while the negative predictive value was 13%. The impingement test is helpful in identifying acetabular labral tears. If this test is negative and if a labral tear is still suspected, ultrasound can reliably diagnose most tears of the acetabular labrum. MR arthrography is indicated in cases where ultrasound is negative, but the patient suffers continued, specific symptoms.

28 July 2016 in Arthritis Care & Research
Verified
Journal Article
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BSBirgit Skoffer
Birgit Skoffer
Thomas MariboThomas Maribo
Thomas Maribo
EMElisabeth Mechlenburg Møller
Elisabeth Mechlenburg Møller
PHPer M. Hansen
Per M. Hansen
KSKjeld Soballe
Kjeld Soballe
UDUlrik Dalgas
Ulrik Dalgas

1 December 2017 in Journal of Science and Medicine in Sport
Verified
Journal Article
Closed access
SKSigne Kierkegaard
Signe Kierkegaard
EMElisabeth Mechlenburg Møller
Elisabeth Mechlenburg Møller
BLBent Lund
Bent Lund
KSKjeld Soballe
Kjeld Soballe
UDUlrik Dalgas
Ulrik Dalgas