Fibroblast growth factors (FGFs) are crucial signaling proteins that govern numerous cellular activities, such as proliferation, differentiation, and tissue repair. Recent studies indicate that FGFs, particularly FGF-2, are pivotal in viral replication by altering the host cell environment to promote viral survival, replication, and immune evasion. Viruses rely on host cell components for their replication and often manipulate host signaling pathways, including FGF signaling, to optimize their environment for viral growth. Among the various FGFs, FGF-2 (basic FGF) stands out as particularly influential in viral replication due to its roles in angiogenesis, cell survival, and immune modulation. This chapter explores the molecular processes via which various FGFs affect viral life cycles, particularly highlighting FGF-2, which is notably important in promoting viral replication via its impact on cell survival, angiogenesis, and inflammation. Understanding FGF-mediated viral replication may offer new therapeutic targets for viral infections.