Merging produced a structured jet: The binary neutron star merger event GW170817 was observed with gravitational waves and across the electromagnetic spectrum. However, the physical processes that produced that emission remain poorly understood, particularly the late-time x-ray and radio emission. Ghirlanda et al. observed the radio afterglow with an interferometric array of 32 radio telescopes spread across the globe. The size and position of the radio source are not compatible with a uniformly expanding cocoon, as some have suggested. Instead, the data indicate that GW170817 produced a structured jet of material that escaped the surrounding ejecta and is now expanding into the interstellar medium at relativistic speeds. Science , this issue p. 968

Increasing evidence suggests that long noncoding RNAs (lncRNAs) play crucial roles in various biological processes. However, little is known about the effects of lncRNAs on autophagy. Here we report that a lncRNA, termed cardiac autophagy inhibitory factor (CAIF), suppresses cardiac autophagy and attenuates myocardial infarction by targeting p53-mediated myocardin transcription. Myocardin expression is upregulated upon H₂O₂ and ischemia/reperfusion, and knockdown of myocardin inhibits autophagy and attenuates myocardial infarction. p53 regulates cardiomyocytes autophagy and myocardial ischemia/reperfusion injury by regulating myocardin expression. CAIF directly binds to p53 protein and blocks p53-mediated myocardin transcription, which results in the decrease of myocardin expression. Collectively, our data reveal a novel CAIF-p53-myocardin axis as a critical regulator in cardiomyocyte autophagy, which will be potential therapeutic targets in treatment of defective autophagy-associated cardiovascular diseases.

The evolution of symmetric extragalactic radio sources can be characterized by four distinct growth stages of the radio luminosity versus size of the source. The interaction of the jet with the ambient medium results in the formation and evolution of sources with non-standard (flaring) morphology. In addition, cessation or restarting of the jet power and obstruction of the jet will also result in distinct morphological structures. The radio source population may thus be classified in morphological types that indicate the prevailing physical processes. Compact symmetric objects (CSOs) occupy the earliest evolutionary phase of symmetric radio sources and their dynamical behavior is fundamental for any further evolution. Analysis of CSO dynamics is presented for a sample of 24 CSOs with known redshift and hotspot separation velocity and with a large range of radio power. Observables such as radio power, separation between two hotspots, hotspot separation velocity, and kinematic age of the source are found to be generally consistent with the self-similar predictions for individual sources that reflect the varying density structure of the ambient interstellar medium. Individual sources behave different from the group as a whole. The age and size statistics confirm that a large fraction of CSOs does not evolve into extended doubles.

We describe a new low-frequency wideband radio survey of the southern sky. Observations covering 72–231 MHz and Declinations south of $+30^\circ$ have been performed with the Murchison Widefield Array “extended” Phase II configuration over 2018–2020 and will be processed to form data products including continuum and polarisation images and mosaics, multi-frequency catalogues, transient search data, and ionospheric measurements. From a pilot field described in this work, we publish an initial data release covering 1,447 $\mathrm{deg}^2$ over $4\,\mathrm{h}\leq \mathrm{RA}\leq 13\,\mathrm{h}$ , $-32.7^\circ \leq \mathrm{Dec} \leq -20.7^\circ$ . We process twenty frequency bands sampling 72–231 MHz, with a resolution of 2′–45^′′, and produce a wideband source-finding image across 170–231 MHz with a root mean square noise of $1.27\pm0.15\,\mathrm{mJy\,beam}^{-1}$ . Source-finding yields 78,967 components, of which 71,320 are fitted spectrally. The catalogue has a completeness of 98% at ${{\sim}}50\,\mathrm{mJy}$ , and a reliability of 98.2% at $5\sigma$ rising to 99.7% at $7\sigma$ . A catalogue is available from Vizier; images are made available via the PASA datastore, AAO Data Central, and SkyView. This is the first in a series of data releases from the GLEAM-X survey.