Screening mammography reduces breast cancer mortality, but studies analyzing interval cancers diagnosed after negative screens have shown that many cancers are missed. Supplemental screening using magnetic resonance imaging (MRI) can reduce the number of missed cancers. However, as qualified MRI staff are lacking, the equipment is expensive to purchase and cost-effectiveness for screening may not be convincing, the utilization of MRI is currently limited. An effective method for triaging individuals to supplemental MRI screening is therefore needed. We conducted a randomized clinical trial, ScreenTrustMRI, using a recently developed artificial intelligence (AI) tool to score each mammogram. We offered trial participation to individuals with a negative screening mammogram and a high AI score (top 6.9%). Upon agreeing to participate, individuals were assigned randomly to one of two groups: those receiving supplemental MRI and those not receiving MRI. The primary endpoint of ScreenTrustMRI is advanced breast cancer defined as either interval cancer, invasive component larger than 15 mm or lymph node positive cancer, based on a 27-month follow-up time from the initial screening. Secondary endpoints, prespecified in the study protocol to be reported before the primary outcome, include cancer detected by supplemental MRI, which is the focus of the current paper. Compared with traditional breast density measures used in a previous clinical trial, the current AI method was nearly four times more efficient in terms of cancers detected per 1,000 MRI examinations (64 versus 16.5). Most additional cancers detected were invasive and several were multifocal, suggesting that their detection was timely. Altogether, our results show that using an AI-based score to select a small proportion (6.9%) of individuals for supplemental MRI after negative mammography detects many missed cancers, making the cost per cancer detected comparable with screening mammography. ClinicalTrials.gov registration: NCT04832594.

The special issue entitled “Developments in Quantitative Assessment and Modeling of Mineral Resource Potential” is composed of 17 papers that cover a diverse range of approaches to mineral resource assessment, including mainly multivariate statistical analysis, fractal and multifractal modeling, geostatistical modeling, machine learning, mathematical morphology and 3D mineral exploration. This introductory article first provides an overview of the developments and existing methods in quantitative assessment of mineral resources. Then, brief introductions of each of the 17 papers are provided. These papers can be grouped into three themes: (1) multifractal theory for mineral resource assessment; (2) machine learning for mineral prospectivity mapping; and (3) GIS-based 3D modeling for mineral exploration. The 17 papers either proposed novel methods or demonstrated innovative applications of existing methods.

The current study aims at assessing the capabilities of five machine learning models in terms of mapping tungsten polymetallic prospectivity in the Gannan region, China. The five models include logistic regression (LR), support vector machine (SVM), random forest, convolutional neural network (CNN), and light gradient boosting machine (LGBM) models. Three types of data sets including geochemical data, lithostratigraphic contacts, and faults were employed to generate 16 evidential maps that were used to build the machine learning models. Tungsten polymetallic deposits were randomly separated into two parts: 80% for training and 20% for validating. Performance of the models was evaluated through receiver operating characteristic and K‐fold cross validation, with an emphasis on the variable influence within different machine learning methods. The results show that the models are especially sensitive to the chemical elements: Be, Bi, Pb, and Cd, implying that they are closely related to tungsten polymetallic mineralization. Compared to other models, the LGBM and CNN models performed best, while the LR model was the most stable. The results also indicated that the CNN model can predict the maximum number of tungsten polymetallic deposits within the minimum area based on the prediction‐area plot analysis, while the SVM model can capture the least amount of tungsten polymetallic deposits within the largest area. Finally, 18 prospective areas were delineated according to the prediction results of the machine learning models, which provided important guidance for tungsten polymetallic exploration in the study area.

The flexible geometry configuration of the bistatic synthetic aperture radar (SAR) has many advantages. However, it causes serious measurement error in the bistatic SAR system, which degrades the quality of the SAR images and the precision of the digital elevation model (DEM) obtained using stereoscopy bistatic SAR. In this paper, the influence of the scene height estimation error, trigger delay, transmitter position measurement error, receiver position measurement error, and transmission line length measurement error are analyzed. These analyses are very useful in bistatic SAR system design. The scene height estimation error, trigger delay, transmitter position measurement error, and synchronization receiver position measurement error affect both the quality of the images and the precision of the DEM obtained by stereoscopy bistatic SAR slightly. The echo receiver position measurement error and transmission line length measurement error affect the quality of the imaging only slightly, but seriously affect the precision of the DEM obtained by stereoscopy bistatic SAR. Luckily, their measurement precision can be quite satisfactory. Simulations and real bistatic experimental results verify the proposed theoretical analysis.