Background: Pilomatrix carcinoma (PC) is a rare skin tumor arising from hair follicle matrix cells. It is locally aggressive with a high rate of local recurrence after surgical excision. Few cases in the literature have been described and the management is not well defined. Objectives: The aim of this study was to present two cases of PC located on the head and review the relevant literature about epidemiology, clinical and dermoscopic evaluation, characteristics of local and distant metastases, local recurrence rate and management of this rare skin tumor. Methods: We consulted databases from PubMed, Research Gate and Google Scholar, from January 2012 to November 2022. We reviewed the literature and reported two additional cases. Results: We selected 52 tumors in middle-aged to older patients located mostly on the head. Dermoscopy evaluation was rarely performed in the pre-operative diagnostic setting. The most definitive treatment was wide local excision, but local recurrences were common. In total, we observed 11 cases of recurrences and 9 patients with locoregional or distant metastases. Four patients received adjuvant radiotherapy, two patients needed chemotherapy and local cancer therapy and one patient received radiochemotherapy. Conclusion: Our reports and the review of the literature can provide a better awareness and management of this rare tumor.

Citation: Bazzacco G, Conforti C, Toffoli L, Zelin E, Zalaudek I, di Meo N. Dermoscopic Features of Herpes Zoster: Case Series and Review of the Literature. Dermatol Pract Concept. 2023;13(3):e2023149. DOI: https://doi.org/10.5826/dpc.1303a149 Accepted: January 14, 2023; Published: July 2023 Copyright: ©2023 Bazzacco et al. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (BY-NC-4.0), https://creativecommons.org/licenses/by-nc/4.0/, which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original authors and source are credited. Funding: None. Competing interests: None. Authorship: All authors have contributed significantly to this publication. Corresponding author: Giulia Bazzacco, MD, Dermatology Clinic of Trieste, Maggiore Hospital, University of Trieste, Trieste, Italy Phone: +39 0403992056 Email: giuliabazzacco@gmail.com Keywords : Herpes, zoster, dermoscopy, clues, halo This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Recently, ultrasound has emerged as an important tool for studying hidradenitis suppurativa (HS), enabling differentiation between abscesses and fistulas and the assessment of various disease features. However, data on the use of ultrasound to evaluate treatment response to medical therapy remain limited. This study aims to evaluate the clinical utility of ultrasound in monitoring disease activity in HS patients treated with adalimumab over a 52-week period. This research employs a retrospective approach to analyze ultrasound scores related to fibrosis, edema, power-Doppler (PD) signal, and resistive index (RI) at baseline and after 52 weeks of adalimumab treatment. In total, 311 fistulas from 69 patients were included. Multivariate regression analysis revealed that PD score and edema were associated with the International Hidradenitis Suppurativa Severity Score System (IHS4)-55, as well as with changes in the Dermatology Life Quality Index (DLQI) and pain Visual Analogue Scale (VAS) scores. Moreover, at baseline, healed and non-healed fistulas showed significant differences in PD signal, fibrosis, edema, and RI. Limitations include the retrospective design of the study, a limited population size, and the absence of a control group. However, our data provide evidence that ultrasound can be a reliable tool for assessing patients’ responses to medical therapies.

Citation: Bazzacco G, Zelin E, Maronese CA, et al. Rosette-like structure: a main dermoscopic feature in a small trichilemmal cyst.  Dermatol Pract Concept. 2022;12(1):e2022021. DOI: https://doi.org/10.5826/dpc.1201a21 Accepted: May 26, 2021; Published: January 2022 Copyright: ©2022 Bazzacco et al. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (BY-NC-4.0), https://creativecommons.org/licenses/by-nc/4.0/, which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original authors and source are credited. Funding: None. Competing interests: None. Authorship: All authors have contributed significantly to this publication and approved the final version of the submitted paper. NDM and IZ defined the design and intellectual content of the paper. GB searched for literature, wrote the draft, edited the manuscript and the tables, preparing them for submission. EZ, CAM, and VR reviewed the article with consistent integrations. DS analyzed the histology samples and contributed to image collection. Corresponding author: Enrico Zelin, MD, Dermatology Clinic, Hospital Maggiore, , Trieste, Italy. Email address: enrico.zelin@gmail.com Keywords : trichilemmal cyst, rosette, dermoscopy This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

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