Dimitris Zacharoulis

Dr. Dimitris Zacharoulis

Department of Surgery, University of Thessaly, Biopolis, Larissa, Greece

Research Focus & Metrics

Academic Career Length

22Years (2005-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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5 April 2018 in Gastroenterology Research and Practice
Verified
Journal Article
Open access
PDF file
ESEleni Sioka
Eleni Sioka
GTGeorge Tzovaras
George Tzovaras
KPKonstantinos Perivoliotis
Konstantinos Perivoliotis
VBVissarion Bakalis
Vissarion Bakalis
EZEleni Zachari
Eleni Zachari
Dimitris ZacharoulisDimitris Zacharoulis
Dimitris Zacharoulis
Objective. Laparoscopic sleeve gastrectomy (LSG) was considered mainly as a restrictive procedure due to anatomic alterations in the upper gastrointestinal tract. Additionally, due to neurohormonal alterations, LSG modifies the gastrointestinal motility, which controls appetite and feeling of satiety. Aim. The aim of the study was to review the impact of laparoscopic sleeve gastrectomy on gastrointestinal motility. Material and Methods. A search of the medical literature was undertaken in Pubmed, Web of Science, and Cochrane library. Esophageal, gastric, bowel motility were assessed separately. Results. Nine studies assessed esophageal motility. The data remain debatable attributing to the heterogeneity of follow-up timing, surgical technique, bougie size, and distance from pylorus. The stomach motility was assessed in eighteen studies. Functionally, the sleeve was divided into a passive sleeve and an accelerated antrum. All scintigraphic studies revealed accelerated gastric emptying after LSG except of one. Patients demonstrated a rapid gastroduodenal transit time. The resection of the gastric pacemaker had as a consequence aberrant distal ectopic pacemaking or bioelectrical quiescence after LSG. The bowel motility was the least studied. Small bowel transit time was reduced; opposite to that the initiation of cecal filling and the ileocecal valve transit was delayed. Conclusion. Laparoscopic sleeve gastrectomy has impacts on gastrointestinal motility. The data remain debatable for esophageal motility. Stomach and small bowel motility were accelerated, while the initiation of cecal filling and the ileocecal valve transit was delayed. Further pathophysiological studies are needed to evaluate the correlation of motility data with clinical symptoms.

24 July 2010 in Obesity Surgery
Verified
Journal Article
Closed access
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GTGeorge Triantafyllidis
George Triantafyllidis
OLOlga Lazoura
Olga Lazoura
ESEleni Sioka
Eleni Sioka
GTGeorge Tzovaras
George Tzovaras
AAAfroditi Antoniou
Afroditi Antoniou
Dimitris ZacharoulisDimitris Zacharoulis
Dimitris Zacharoulis

12 May 2011 in Obesity Surgery
Verified
Journal Article
Closed access
PDF file
Dimitris ZacharoulisDimitris Zacharoulis
Dimitris Zacharoulis
ESEleni Sioka
Eleni Sioka
DPDimitris Papamargaritis
Dimitris Papamargaritis
OLOlga Lazoura
Olga Lazoura
CRChristos Rountas
Christos Rountas
GTGeorge Tzovaras
George Tzovaras

3 July 2014 in Journal of Obesity
Verified
Journal Article
Open access
PDF file
ESEleni Sioka
Eleni Sioka
Dimitris ZacharoulisDimitris Zacharoulis
Dimitris Zacharoulis
EZEleni Zachari
Eleni Zachari
DPDimitris Papamargaritis
Dimitris Papamargaritis
OPOurania Pinaka
Ourania Pinaka
GTGeorge Tzovaras
George Tzovaras
Background.The natural history of gallstone formation after laparoscopic sleeve gastrectomy (LSG), the incidence of symptomatic gallstones, and timing of cholecystectomy are not well established.Methods.A retrospective review of prospectively collected database of 150 patients that underwent LSG was reviewed.Results.Preoperatively, gallbladder disease was identified in 32 of the patients (23.2%). Postoperatively, eight of 138 patients (5.8%) became symptomatic. Namely, three of 23 patients (13%) who had evident cholelithiasis preoperatively developed complicated cholelithiasis. From the cohort of patients without preoperative cholelithiasis, five of 106 patients (4.7%) experienced complicated gallstones after LSG. Total cumulative incidence of complicated gallstones was 4.7% (95% CI: 1.3–8.1%). The gallbladder disease-free survival rate was 92.2% at 2 years. No patient underwent cholecystectomy earlier than 9 months or later than 23 months indicating the post-LSG effect.Conclusion.A significant proportion of bariatric patients compared to the general population became symptomatic and soon developed complications after LSG, thus early cholecystectomy is warranted. Routine concomitant cholecystectomy could be considered because the proportion of patients who developed complications especially those with potentially significant morbidities is high and the time to develop complications is short and because of the real technical difficulties during subsequent cholecystectomy.

28 December 2012 in Journal of Investigative Surgery
Verified
Journal Article
Closed access
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Dimitris ZacharoulisDimitris Zacharoulis
Dimitris Zacharoulis
OLOlga Lazoura
Olga Lazoura
ESEleni Sioka
Eleni Sioka
SPSpyros Potamianos
Spyros Potamianos
GTGeorge Tzovaras
George Tzovaras
NHNagy Habib
Nagy Habib
Background: The Habib EndoHPB is a bipolar radiofrequency (RF) catheter developed to be introduced across malignant strictures of the bile ducts, so that RF energy can locally ablate the tumor prior to stent placement. This experiment aims to assess the ability of the catheter to coagulate the wall of the common bile duct (CBD) in a porcine model, to establish power requirement and time parameters and correlate them to the depth of thermal injury, and to assess the ease of operation of the device. Methods: The CBD was catheterized using the device in 20 pigs. RF energy was applied to the CBD wall with various generator settings. The pigs were sacrificed 24 hr after the application and the CBD was excised for histological analysis. Results: The device was easy to handle. Statistically significant correlations between the power, the time of RF application, and the thermal injury depth were found. Conclusion: The Habib EndoHPB catheter can effectively deliver RF energy intraluminally in the porcine CBD. Clinical studies are warranted in order to define proper settings for safe and efficient use in malignant biliary obstruction.

30 November 2012 in Obesity Surgery
Verified
Journal Article
Closed access
PDF file
ESEleni Sioka
Eleni Sioka
GTGeorge Tzovaras
George Tzovaras
KOKonstantinos Oikonomou
Konstantinos Oikonomou
GKGeorgia Katsogridaki
Georgia Katsogridaki
EZEleni Zachari
Eleni Zachari
Dimitris ZacharoulisDimitris Zacharoulis
Dimitris Zacharoulis