Prof. Dr. Hassan Azzazy
American University in Cairo
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Academic Career Length
33Years (1994-Present)
(Calculated once Scilit publication data is synced: current year − year of first publication + 1)
Representative Publications
View All Publications31 January 2023 in ACS Omega
Journal Article
YMYasmin R. Maghraby
Yasmin R. MaghrabyRERehan M. El-Shabasy
Rehan M. El-Shabasy
AIAhmed H. Ibrahim
Ahmed H. Ibrahim
Hassan AzzazyEnzymes play vital roles in diverse industrial sectors and are essential components of many industrial products. Immobilized enzymes possess higher resistance to environmental changes and can be recovered/recycled easily when compared to the free forms. The primary benefit of immobilization is protecting the enzymes from the harsh environmental conditions (e.g., elevated temperatures, extreme pH values, etc.). The immobilized enzymes can be utilized in various large-scale industries, e.g., medical, food, detergent, textile, and pharmaceutical industries, besides being used in water treatment plants. According to the required application, a suitable enzyme immobilization technique and suitable carrier materials are chosen. Enzyme immobilization techniques involve covalent binding, encapsulation, entrapment, adsorption, etc. This review mainly covers enzyme immobilization by various techniques and their usage in different industrial applications starting from 1992 until 2022. It also focuses on the multiscale operation of immobilized enzymes to maximize yields of certain products. Lastly, the severe consequence of the COVID-19 pandemic on global enzyme production is briefly discussed.
1 September 2002 in Clinical Biochemistry
Journal Article
Hassan AzzazyWHW.EDward Highsmith
W.EDward Highsmith
1 September 2007 in Clinical Biochemistry
Journal Article
Hassan AzzazyMMMai M.H. Mansour
Mai M.H. Mansour
SKSteven C. Kazmierczak
Steven C. Kazmierczak
1 July 2006 in Clinical Chemistry
Journal Article
Hassan AzzazyMMMai M.H. Mansour
Mai M.H. MansourSKSteven C. Kazmierczak
Steven C. Kazmierczak
Background: The use of nanotechnologies for diagnostic applications shows great promise to meet the rigorous demands of the clinical laboratory for sensitivity and cost-effectiveness. New nanodiagnostic tools include quantum dots (QDs), gold nanoparticles, and cantilevers. QDs, which are the most promising nanostructures for diagnostic applications, are semiconductor nanocrystals characterized by high photostability, single-wavelength excitation, and size-tunable emission. QDs and magnetic nanoparticles can be used for barcoding of specific analytes. Gold and magnetic nanoparticles are key components of the bio-barcode assay, which has been proposed as a future alternative to the PCR.
1 July 2009 in Expert Review of Molecular Diagnostics
Journal Article
SRSarah H Radwan
Sarah H RadwanHassan AzzazyGold nanoparticles (AuNPs) exhibit a unique phenomenon, known as surface plasmon resonance, which is responsible for their large absorption and scattering cross-sections, which are four to five orders of magnitude larger than those of conventional dyes. In addition, their optical properties can be controlled by varying their sizes, shapes and compositions. AuNPs can be easily synthesized and functionalized with different biomolecules including oligonucleotides. Numerous methods have been utilized for detecting AuNPs such as colorimetric, scanometric, fluorescence, surface-enhanced Raman scattering and electrochemical techniques. These unique aspects have permitted the development of novel AuNP-based assays for molecular diagnostics which promise increased sensitivity and specificity, multiplexing capability, and short turnaround times. AuNP-based colorimetric assays in particular show great potential in point-of-care testing assays. This review discusses properties of AuNPs and their utilization for the development of novel molecular assays.
1 August 2015 in Analytica Chimica Acta
Journal Article
About Me
Dr. Hassan Azzazy is a tenured Distinguished University Professor and Chairman of the Department of Chemistry at the American University in Cairo. Before joining AUC, Dr. Azzazy was a postdoctoral fellow and assistant professor at the University of Maryland School of Medicine, Baltimore, MD. He holds board certifications in Clinical Chemistry and Molecular Diagnostics from the American Board of Clinical Chemistry, Washington, DC. He is certified as a Specialist in Chemistry by the American Society for Clinical Pathology in Chicago (USA) and is a fellow of the Royal Society of Chemistry (UK).
He has over 30 years of biomedical research experience with a focus on developing novel diagnostics for the detection of infectious agents and cancer markers, optical chemosensors for the detection of environmental toxins, biodegradable nanofibrous wound dressings, and targeted drug delivery using nanocarriers. Dr. Azzazy has received many awards, including the State Prize in Laboratory Medicine (Egypt), Global Innovator Award (Texas Christian University), Arab Innovation and Entrepreneurship Award (UAE), Shoman Award in Medical Sciences (Jordan), Life Achievement Award (American Society for Clinical Pathology), and State Merit Prize in Advanced Technological Sciences (Egypt). Dr. Azzazy is a strong advocate of entrepreneurship and has cofounded two biomedical startup companies.