Background: The hypothalamic–pituitary axis by secreting neuropeptides plays a key role in metabolic homeostasis. In light of the metabolic regulation, oxytocin is a potential neuropeptide for therapies against obesity and related disorders. The aim of our study is to measure ghrelin-induced oxytocin secretion in rats and to detect the changes after administration of ghrelin antagonist. Methods: Ghrelin was administrated centrally (intracerebroventricular, i.c.v., 1.0, 10.0, and 100.0 pmol) or systemically (intravenous, i.v., 1.0, and 10.0 nmol). [d-Lys³]-GHRP-6 ghrelin antagonist was injected 15 min before ghrelin injection in a dose of 10.0 pmol i.c.v. and 10.0 nmol i.v. Results: Either i.c.v. or i.v. administration of ghrelin dose-dependently increased the plasma oxytocin concentration. Following pretreatment with the ghrelin antagonist [d-Lys³]-GHRP-6, the high plasma oxytocin level induced by ghrelin was significantly reduced. Conclusion: The results indicate that the release of oxytocin is influenced directly by the ghrelin system. Examination of the mechanism of ghrelin-induced oxytocin secretion is a new horizon for potential therapeutic options.

The KIDSCREEN-27 represents a standardized, worldwide instrument, employed to assess the health-related quality of life in children. The purpose of the present study is to validate the KIDSCREEN-27 questionnaire for 6-year-old preparatory school children and verify its reliability, as well as to perform a comparison regarding the quality of children’s lives living in two cities in Romania: Arad, a provincial city, versus the second most developed city in the country, Cluj-Napoca. A total of 256 children of 6 years of age, who come from families with both parents, with a medium to high socioeconomic status and a good health status, were included in the analysis, using the KIDSCREEN-27 questionnaire at three assessment time points with a re-test period of two weeks. Results indicated that the KIDSCREEN-27 turned out to be suitable for use in 6-year-old Romanian children. Analysis regarding the psychometric properties showed that the Cronbach’s alpha ranged from 0.554 to 0.661 at the end of the study. The Pearson correlation coefficients showed statistically significant differences between the items of each area investigated. In conclusion, there is a growing need to periodically monitor the health status of children to avoid possible problems which may occur.

Exercise addiction (EA) is a maladaptive behavior characterized by excessive physical activity, often linked to negative psychological outcomes. This study investigated the relationships between perfectionism, sport commitment, and EA in a sample of 219 Hungarian athletes (M = 22.19 years). Using path analysis, we tested a model hypothesizing that adaptive and maladaptive perfectionism differentially predict enthusiastic and constrained commitment, which in turn influences EA. Our results showed that maladaptive perfectionism positively predicted constrained commitment (β = 0.70) and EA (β = 0.63), while negatively relating to enthusiastic commitment (β = −0.17). Conversely, adaptive perfectionism was positively associated with enthusiastic commitment (β = 0.24) and negatively with constrained commitment (β = −0.12). Moreover, enthusiastic commitment positively predicted EA (β = 0.24). We found a significant indirect effect between adaptive and maladaptive perfectionism when controlling for enthusiastic commitment, suggesting its dual role in this context. Our study suggests that enthusiastic commitment serves as a source of exercise addiction (EA) and has a dual role, acting as both a protective factor and a risk factor for it. Additionally, we found that maladaptive perfectionism is associated with higher levels of constrained commitment and EA, while correlating with lower levels of enthusiastic commitment. Conversely, adaptive perfectionism increases enthusiastic commitment and decreases constrained commitment. These findings highlight the associations between motivational and personality factors in EA, indicating that even adaptive traits can contribute to unhealthy exercise patterns in athletic environments.