The effectiveness of enterprise human resource management is an important topic of human resource management in academic studies, and it is the key for enterprises to achieve long-term sustainable development. Up to now, fruitful research achievements have been achieved, but there is still a lack of a systematic literature review. Based on 218 research results collected in the CNKI and SSCI databases of the WOS from 1975 to 2021, this paper systematically reviews the enterprise human resource management effectiveness from the aspects of evolution, topic overview, and content sorting by using bibliometrics with Citespace software and a systematic literature review. This paper expounds the concept of enterprise human resource management effectiveness, analyzes the existing research results, and finds out where the research gap is. Based on this, this paper puts forward the prospect of future research topics from the aspects of measurement methods, influencing factors, and results, which not only helps to systematically reveal the overview of the existing research in the field of enterprise human resource management effectiveness, but also provides direction for further research.