The construction industry is considered to have a high potential in achieving the sustainable development goals. The circular economy is a promising framework that supports the shift from a linear-construction industry to an environmental-friendly and efficient sector. On the other hand, there is a lack of effort in measuring the impact of construction-related activities on users and society. The gap is greater when the context of social impacts is related to circular and bio-based construction. For this purpose, a social impact assessment framework was developed in the Interreg 2 seas CBCI project and tested on a residential prototype: Living Lab (LL) Ghent. Under 13 impact categories relevant to 4 stakeholder categories, circular and bio-based construction materials and methods were assessed for production and construction phases. Qualitative and quantitative data were collected through expert workshops and questionnaires. The results include identification of new indicators (urban mining, social economy, and post-intervention manuals) for several circular construction methods. The social impacts of the LL were discussed depending on each stakeholder category. It was seen that there are several positive impacts related to workers and the local community. Certain recommendations were also provided specifically on a construction-sector basis which may be integrated into existing social impact assessment guidelines.