Marko Mladenović

Dr. Marko Mladenović

Chemistry, University of Nis, Faculty of Sciences and Mathematics, Niš, Serbia
orcid
Senior Research Associate/Assistant Professor (Faculty of Sc...

Research Focus & Metrics

Academic Career Length

6Years (2021-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 February 2022 in Journal of Ethnopharmacology
Verified
Journal Article
Closed access
Nikola M StojanovićNikola M Stojanović
Nikola M Stojanović
MMMarko Mladenović
Marko Mladenović
AMAleksandra Maslovarić
Aleksandra Maslovarić
NSNenad I. Stojiljković
Nenad I. Stojiljković
Pavle RandjelovicPavle Randjelovic
Pavle Randjelovic
NRNiko S. Radulović
Niko S. Radulović


1 December 2022 in Plants
Verified
Journal Article
Open access
PDF file
NRNiko S. Radulović
Niko S. Radulović
MMMarko Mladenović
Marko Mladenović
DVDušan R. Vukićević
Dušan R. Vukićević
Nikola M StojanovićNikola M Stojanović
Nikola M Stojanović
Pavle RandjelovicPavle Randjelovic
Pavle Randjelovic
Fabio BoylanFabio Boylan
Fabio Boylan
Motivated by the ethnopharmacological use of Pulicaria dysenterica, in the present study, the antimicrobial potential of the extracted essential oil was investigated against a panel of eighteen microorganism strains. Additionally, anti-acetylcholinesterase and antispasmodic (isolated rat distal colon) activities, general acute toxicity (Artemia salina model), and immunomodulatory properties (cytotoxicity on isolated mouse macrophages) were studied. Detailed analyses of the essential oil led to the identification of 3-methoxycuminyl 2-methylbutanoate (a new natural product) and 3-methoxycuminyl 3-methylbutanoate (a rare natural product). The obtained esters and intermediates in the synthesis of the starting alcohol (3-methoxycuminol) were subjected to a battery of 1D- and 2D-NMR experiments. The synthesized esters were additionally characterized by GC–MS, IR, and UV–Vis. The synthesized compounds (ten in total) were biologically tested in the same way as the extracted P. dysenterica essential oil. The obtained low acute toxicity and promising antimicrobial potential suggest that the P. dysenterica essential oil might partially explain the ethnopharmacological application of P. dysenterica plant material for the treatment of gastrointestinal infections.


14 January 2025 in Molecules
Verified
Journal Article
Open access
PDF file
MDMilan Dimitrijević
Milan Dimitrijević
MMMarko Mladenović
Marko Mladenović
MNMilica Nešić
Milica Nešić
MDMilan Dekic
Milan Dekic
VRVidak Raicevic
Vidak Raicevic
NRNiko S. Radulović
Niko S. Radulović
Species of the genus Doronicum are known for their pharmacological properties and essential oils, the chemical composition of which remains inadequately studied. In this work, GC-MS analysis, synthesis, and spectral techniques (UV, IR, MS, and NMR) were employed to identify 83 constituents in the essential oil from D. columnae roots, which accounted for 98.1% of the total GC-peak area. The major components were thymyl isobutyrate (32.8%) and thymyl 2-methylbutyrate (22.8%), while the minor constituents were methoxy-p-cymene derivatives. Six new natural products were identified through synthesis, GC co-injection experiments and spectral characterization, including esters (isobutyrate, 2-methylbutyrate, and/or isovalerate) of 2-methoxycuminol, 6-methoxythymol, and 6-hydroxythymyl methyl ether, as well as methyl 3-methoxycuminate. Their identification was made possible by synthesis efforts, as isolating pure compounds was impracticable because of their low abundance and the overall structural similarity within the highly complex mixture that was the essential oil.

1 March 2021 in Journal of Molecular Structure
Verified
Journal Article
Closed access
NRNiko S. Radulović
Niko S. Radulović
MTMagdalena M. Tasić
Magdalena M. Tasić
MMMarko Mladenović
Marko Mladenović