Regina Klimova

Dr. Regina Klimova

Gamaleya National Research Center for Epidemiology and Microbiology of the Russian Ministry of Health, Moscow, Moskva, Russia
orcid

Research Focus & Metrics

Academic Career Length

24Years (2003-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 June 2012 in Virus Research
Verified
Journal Article
Closed access
IRIrina Rudneva
Irina Rudneva
AIAnna Ignatieva
Anna Ignatieva
TTTatiana Timofeeva
Tatiana Timofeeva
ASAleksandr Shilov
Aleksandr Shilov
AKAlla Kushch
Alla Kushch
NKNikolai Kaverin
Nikolai Kaverin

1 September 2012 in Mendeleev Communications
Verified
Journal Article
Closed access
NFNataliya E. Fedorova
Nataliya E. Fedorova
RKRegina Klimova
Regina Klimova
YTYurii A. Tulenev
Yurii A. Tulenev
ECEvgenii V. Chichev
Evgenii V. Chichev
AKAlexey B. Kornev
Alexey B. Kornev
AKAlla Kushch
Alla Kushch

1 January 2011 in Herpesviridae
Verified
Journal Article
Open access
PDF file
VNVictor A Naumenko
Victor A Naumenko
YTYurii A Tyulenev
Yurii A Tyulenev
SYSergei A Yakovenko
Sergei A Yakovenko
LKLubov' F Kurilo
Lubov' F Kurilo
LSLudmila V Shileyko
Ludmila V Shileyko
AKAlla Kushch
Alla Kushch
The presence of human cytomegalovirus (HCMV) in male genital tract suggests its vertical transmission with spermatozoa and the development of a potentially dangerous fetal infection. The objective of the present study was to evaluate the possibility of intracellular HCMV localization in male germ cells and to examine the effect of the virus on human spermatogenesis.

1 April 2010 in Viral Immunology
Verified
Journal Article
Closed access
IRIrina A. Rudneva
Irina A. Rudneva
AKAlla Kushch
Alla Kushch
OMOlga Masalova
Olga Masalova
TTTatiana A. Timofeeva
Tatiana A. Timofeeva
RKRegina Klimova
Regina Klimova
NKNikolai V. Kaverin
Nikolai V. Kaverin
The highly pathogenic avian influenza H5N1 viruses have become widespread and evolved into several clades. In our previous studies, the antigenic sites of the H5 hemagglutinin (HA) were characterized by selection and sequencing of escape mutants. In the present studies we analyzed the antigenic epitopes recognized by monoclonal antibodies against avian influenza A/Duck/Novosibirsk/56/05 (H5N1) virus isolated in western Siberia and belonging to subclade 2.2 of the H5N1 viruses. The analysis revealed several antigenically relevant positions of amino acid residues in the globular head of the HA not encountered earlier in the escape mutants of the H5 subtype. The newly recognized positions (113, 117, 118, 120, and 123, mature H5 numbering) are concentrated in an area adjacent to the region described in earlier studies as corresponding to site B in H3 HA, but extending far beyond this area. The amino acid positions recognized by the monoclonal antibodies against A/Duck/Novosibirsk/56/05 (H5N1) virus differ from the positions recognized by the monoclonal antibodies against H5N2 influenza viruses. The data suggest that the evolution of the HA of H5 avian influenza viruses is associated not only with the changes of antigenic epitopes recognized by antibodies, but also with a change in the dominance of the immunogenicity of different sites in the HA.

1 February 2007 in Doklady Biological Sciences
Verified
Journal Article
Closed access
PDF file
EBE. N. Bocharova
E. N. Bocharova
LZL. E. Zavalishina
L. E. Zavalishina
EBE. E. Bragina
E. E. Bragina
RKRegina Klimova
Regina Klimova
YGYu. K. Gusak
Yu. K. Gusak
AKAlla Kushch
Alla Kushch

1 May 2018 in Bioorganic & Medicinal Chemistry
Verified
Journal Article
Closed access
VKVasiliy S. Koval
Vasiliy S. Koval
AAAlbert F. Arutyunyan
Albert F. Arutyunyan
VSVictor L. Salyanov
Victor L. Salyanov
RKRegina Klimova
Regina Klimova
AKAlla Kushch
Alla Kushch
AZAlexei L. Zhuze
Alexei L. Zhuze