2 February 2021 in Scientific Reports
Parkinson's disease (PD) is characterized by motor impairment, affecting quality of life and increasing fall risk, due to ineffective postural control. To this day, the diagnosis remains based on clinical approach. Similarly, motor evaluation is based on heterogeneous, operator-dependent observational criteria. A synthetic, replicable index to quantify motor impairment is still lacking. Hence, we have designed a new measure of postural stability which assesses the trunk displacement in relation to the center of mass, that we named trunk displacement index (TDI). Twenty-three PD patients and twenty-three healthy controls underwent motor examination through a stereophotogrammetric system. A correlation analysis was performed to assess the relationship of TDI with gait parameters and clinical motor scale (UPDRS-III). The TDI sensitivity was estimated, comparing pre- and post- L-DOPA subclinical dose intake. The TDI showed significant correlations with many gait parameters and with the UPDRS-III. Furthermore, the TDI resulted capable in discriminating between off and on state in PD, whereas gait parameters failed two show any difference between those two conditions. Our results suggest that the TDI may be considered a highly sensitive biomechanical index, reflecting the overall motor condition in PD, and provided of clinical relevance due to the correlation with the clinical evaluation.
31 December 2022 in Form@re - Open Journal per la formazione in rete
Physical activity is involved in increasing health potential. However, in sports practice a state of well-being may depend on the management of emotions. The purpose of the present study was to analyse the relationship between the type of exercise and alexithymia. Three groups of people were analyzed for the study: triathlon practitioners, people practicing Tai Chi, and sedentary people. All participants were assessed for both physical activity level and alexithymia. The results show that more athletes with alexithymia practice high-intensity exercise. Thus, there seems to be an association between alexithymia and exercise addiction. Through competitive exercise, athletes can overcome difficult challenges by employing cognitive resources on external factors, without focusing attention inward. A question emerges from this study: is alexithymia a determining factor in choosing a specific type of physical activity, or could alexithymia be triggered by overtraining? This aspect could be investigated in future studies, which could further investigate the relationship between the choice orientation of a specific sport and alexithymia. Esercizio fisico e Alessitimia: rischio o beneficio? L’attività fisica è coinvolta nell’aumento del potenziale di salute. Tuttavia, nella pratica sportiva uno stato di benessere può dipendere dalla gestione delle emozioni. Lo scopo del presente studio è stato quello di analizzare la relazione tra il tipo di esercizio fisico e l’alessitimia. Per lo studio sono stati analizzati tre gruppi di persone: praticanti di triathlon, persone che praticano il Tai Chi e persone sedentarie. Tutti i partecipanti sono stati sottoposti a una valutazione sia del livello di attività fisica che dell’alessitimia. I risultati mostrano che un maggior numero di atleti con alessitimia pratica esercizi ad alta intensità. Sembra quindi esistere un’associazione tra alessitimia e dipendenza da esercizio fisico. Attraverso l’esercizio agonistico, gli atleti possono superare sfide difficili impiegando le risorse cognitive su fattori esterni, senza focalizzare l’attenzione verso l’interno. Da questo studio emerge una domanda: l’alessitimia è un fattore determinante nella scelta di uno specifico tipo di attività fisica, oppure l’alessitimia potrebbe essere innescata dal sovrallenamento? Questo aspetto potrebbe essere indagato in studi futuri, che potrebbero approfondire la relazione tra l’orientamento alla scelta di uno sport specifico e l’alessitimia.
10 October 2020 in bioRxiv
Brain connectome fingerprinting is rapidly rising as a novel influential field in brain network analysis. Yet, it is still unclear whether connectivity fingerprints could be effectively used for mapping and predicting disease progression from human brain data. We hypothesize that dysregulation of brain activity in disease would reflect in worse subject identification. Hence, we propose a novel framework, Clinical Connectome Fingerprinting , to detect individual connectome features from clinical populations. We show that “clinical fingerprints” can map individual variations between elderly healthy subjects and patients undergoing cognitive decline in functional connectomes extracted from magnetoencephalography data. We find that identifiability is reduced in patients as compared to controls, and show that these connectivity features are predictive of the individual Mini-Mental State Examination (MMSE) score in patients. We hope that the proposed methodology can help in bridging the gap between connectivity features and biomarkers of brain dysfunction in large-scale brain networks.