Recent studies in the human literature suggest that serum bile acid concentrations could be an early predictor of short-term survival in critically ill patients. However, there is no available information in the veterinary literature regarding serum bile acid concentrations in dogs with sepsis. We aimed to evaluate if resting serum bile acid concentrations differ between septic and non-septic dogs. This was a retrospective observational study, of medical records at a single referral center over a twelve-year period. Twenty-six client-owned dogs diagnosed with sepsis were identified. Twenty-one dogs presenting with a non-hepatobiliary systemic disease and twenty-nine dogs admitted for an elective orthopedic procedure, considered otherwise healthy, were selected as control groups. Resting serum bile acid concentrations were significantly higher in the septic compared to the non-septic groups (ill control and orthopedic control groups). However, when assessing bile acid concentrations between groups individually, no difference was identified between the septic and the orthopedic control group. These results should be interpreted cautiously.

Bacterial liver parenchymal infections in dogs are rarely documented, and their imaging characteristics are scarce in the veterinary literature, especially in Computed Tomography (CT). This retrospective multicentric study aimed to describe the CT characteristics of parenchymal bacterial liver infection and abscessation in dogs and compare them with the human literature. Twenty dogs met the inclusion criteria. All dogs, except one, showed discrete hepatic lesions consistent with pyogenic liver abscess (19/20). A single case showed diffuse liver changes, which was diagnosed with granulomatous bacterial hepatitis (1/20). Multifocal lesions were associated with the presence of abdominal pain (p = 0.023). CT characteristics of pyogenic liver abscesses in our study resemble those described in the human literature, with multifocal (14/19) or single (5/19), round or ovoid (19/19), hypoattenuating hepatic lesions, which are better visualised in post-contrast images. Pyogenic liver abscesses can also show features such as the “cluster sign” (8/19), transient arterial segmental enhancement (6/10), rim enhancement (6/19), and intralesional gas (4/19). Additional CT findings, such as local lymphadenomegaly (18/20), peritoneal fat stranding (14/20), and peritoneal fluid (13/20), are also commonly observed.