Airway management procedures, such as endotracheal intubation (ETI), pose a significant risk of aerosol generation, requiring robust personal protective equipment (PPE) against aerosol-generating procedures (AGP). This study aimed to assess the impact of PPE-AGP on intubation success rates, time to intubation, and glottic visualization using ETView and a standard Macintosh laryngoscope (MAC). A total of 52 physicians participated in this prospective, observational, randomized crossover study conducted in a medical simulation setting. Participants included COVID-19 patients with cardiac arrest scenarios with and without PPE-AGP who were intubated with ETView and MAC. During intubation without PPE-AGP, ETView showed a similar first-pass success rate (FPS) but had a shorter intubation time and better glottal hydration compared to MAC. In scenario B (with PPE-AGP), ETView outperformed MAC in FPS, initiation time, and glottic visualization. The use of PPE-AGP had little impact on ETView’s performance. However, it negatively affected the Macintosh laryngoscope, reducing FPS and glottic visibility. Participants found intubation with ETView easier in both scenarios. In conclusion, as compared to the Macintosh laryngoscope, ETView demonstrated higher performance under the circumstances of the simulation, especially when PPE-AGP was used.

Background: Although a large body of literature describes Takotsubo syndrome (TTS) and spontaneous coronary artery dissection (SCAD) as having overlapped clinical features and benign outcome measures, they differ significantly in pathophysiological mechanisms, demo-graphic profile, and natural history of the disease. Herein, we sought to investigate differences in clinical profile and outcomes between patients of these two conditions. Methods: Following PRISMA guidelines, we compared TTS and SCAD in adult patients regarding epidemiological, clinical, and prognostic features. A systematic search of PubMed, Embase, and Cochrane Library identified eligible studies, with data extracted and quality assessed using the Newcastle-Ottawa scale. Random effects models were applied for statistical analysis, with heterogeneity evaluated by I2 and sensitivity analysis conducted to ensure robustness. Results: TTS patients presented more often with dyspnea (46.8% vs. 0.9%; p < 0.001), while SCAD patients displayed typical angina (p < 0.001). In-hospital outcomes were worse for TTS patients, with higher mortality (4.4% vs. 0.8%; RR=7.41, p=0.001) and major adverse cardiac events (43.3% vs. 5.2%; RR=8.35, p < 0.001). At one year, TTS patients had higher all-cause mortality (12.5% vs. 0.8%; p < 0.001) and stroke (2.1% vs. 0.6%; RR=5.08, p=0.02). Keywords: Takotsubo Syndrome Spontaneous Coronary Artery Dissection MINOCA cardio-vascular outcome women's health