Ovarian cancer is the 5^th most common cause of deaths in the women among gynecological tumors. There are many growing evidences that stress and other behavioral factors may affect cancer progression and patient survival. The purpose of this study is to determine the key role of matrix metalloproteinases (MMPs), and cytokines in the aggregation and progression of ovarian cancer. Stress variables (MDA, AGEs, AOPPs, NO), profile of antioxidants (SOD, Catalase, Vitamin E & A, GSH, GRx, GPx) and inflammatory biomarkers (MMP-9, MMP-2, MMP-11, IL-1α and TNF-α) were biochemically assessed from venous blood of fifty ovarian cancer patients and twenty healthy control subjects. The results of all parameters were analyzed statistically by independent sample t-test. The results of the study demonstrated that the levels of stress variables like MDA (3.38±1.12nmol/ml), AGEs (2.72±0.22 ng/ml), AOPPs (128.48±27.23 ng/ml) and NO (58.71±8.67 ng/ml) were increased in the patients of ovarian cancer as compared to control individuals whereas the profile of antioxidants like SOD, Catalase, Vitamin E, Vitamin A, GSH and GRx were decreased in ovarian cancer patients (0.11±0.08 μg/ml, 2.41±1.01μmol/mol of protein, 0.22±0.04 μg/ml, 45.84±9.07μg/ml, 4.88±1.18μg/ml, 5.33±1.26 μmol/ml respectively). But the level of GPx antioxidant was increased in ovarian cancer patients (6.58±0.21μmol/ml). Moreover the levels of MMP-9 (64.87±5.35 ng/ml), MMP-2 (75.87±18.82 ng/ml) and MMP-11 (63.58±8.48 ng/ml) were elevated in the patients. Similarly, the levels of various cytokines TNF-α and IL-1α were also increased in the patients of ovarian cancer (32.17±3.52 pg/ml and 7.04±0.85 pg/ml respectively). MMPs are commonly expressed in ovarian cancer which are potential extrapolative biomarkers and have a major role in metastasis. Due to oxidative stress, different cytokines are released by tumor associated macrophages (TAMs) that result in the cancer progression. Consequently, tissue inhibitors of matrix metalloproteinases (TIMPs) are the valuable therapeutic approaches to complement conservative anticancer strategies.

This article was migrated. The article was marked as recommended. Developments in Outcome-based education (OBE) and innovative shifts in its pedagogical approaches have reshaped the learning environment of curricula at medical schools. This instructional design has gained popularity due to its authenticity and systematic approach. However, this needs organized supervision and faculty training in order to achieve the desired goals for the program. Aim: This article examines the evaluation of OBE at a private medical school in Saudi Arabia. It describes the curriculum review process and the characteristics of the curriculum reviewers involved. It evaluates the curriculum using Harden's OBE implementation inventory. OBE reviewers' satisfaction about OBE implementation was evaluated using the OBE inventory. Results: This analysis shows our institutional profile to be similar to the 'transition to beavers' symbol in Harden's representation. At the program level, the study identifies gaps and suggests suitable recommendations to enhance the enactment of OBE. Conclusion: We strongly encourage medical educators to apply the nine components of the OBE implementation inventory to evaluate their level of implementation of OBE. To further build up this model, the authors propose a mnemonic "ADAPTIVE Species" as an instructional prompt to develop these qualities in medical faculty. "ADAPTIVE Species" stands for Assertive, Developer, Assessors, Prime-movers, Transparent, Innovators, Vigilant, Evaluators, and Selectors.

This article was migrated. The article was marked as recommended. In medical education, peer learning has a significant impact on deeper learning and considered an effective method of collaborative and deeper learning. This article highlights the adjustment of the final year medical students to the peer learning style during the COVID-19 pandemic. It explores the additional benefits of peer learning style and recommend key points that can help medical students to combat the current stressful situation. Adaptation to peer learning strategy may help to overcome this stressful situation and motivate each other to focus on studies. This approach can assist medical students to stay in touch with each other, collaborate, communicate, and boost each other morally. The peer learning style provides an opportunity for students to share thoughts and emotional reactions freely and friendly. This way can help to reduce stress and develop resilience. Students get rapid adaptation to technology-enhanced learning smoothly and effectively by helping each other to learn new skills. The feeling of staying connected with peers during the online sessions significantly augmented the ability to combat the crisis and augment social interactions.

Certainty, artificial intelligence (AI) has a remarkable role in the control of the COVID-19 pandemic globally. This review article aimed to determine the outcomes/benefits associated with the use of artificial intelligence during the COVID-19 pandemic in different specialties in healthcare. Out of 144 articles, 100 publish article abstracts were reviewed using keywords artificial intelligence, intelligent health systems during COVID-19 pandemic, medical education. This review determined that artificial intelligence has a significant role in predicting the spread of disease by chasing the infected population and can prove as a powerful tool for public health professionals. There is a remarkable role of AI-assisted diagnostic features in radiology to specifically diagnose infected cases with COVID-19. AI assists in taking quicker decision making among health professionals through AI operated apps.This review highlights the need for future research which should emphasize determining the effectiveness and challenges of the use of robotics during pandemics.

Oral health significantly impacts overall health, with increasing evidence linking poor oral health to adverse pregnancy outcomes. Periodontal disease, a chronic gum condition, is associated with preterm birth, low birth weight, and preeclampsia. Systemic inflammation and bacterial translocation are proposed mechanisms connecting periodontal disease to pregnancy complications. Maternal immune responses may be impaired, increasing systemic inflammation, and triggering preterm labor. In addition, oral bacteria may reach the uterus, causing localized inflammation and poor outcomes. Intervention trials show mixed results—some small studies report improved birth outcomes after periodontal treatment, while larger trials show no significant effect. These discrepancies highlight the need for further research on patient subgroups, disease categories, and treatment strategies. Prenatal care should emphasize preventive dental care, including regular checkups, good oral hygiene, and treatment of periodontal disease. Addressing oral health during pregnancy can improve outcomes for both mother and child. Future studies should explore the oral‐systemic connection, host susceptibility, and effective interventions for at‐risk individuals. Comprehensive oral health care during pregnancy offers the potential to reduce adverse outcomes and promote better maternal and fetal health.