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Xiaobo Yang
Department of Occupational Health and Environmental Health, School of Public Health, Guangxi Medical University, Nanning, China

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Article
Published: 07 August 2021 in BioMetals
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It is important but remains unclear whether ethylenediaminetetraacetic acid (EDTA) and sodium heparin anticoagulants have different impacts on the levels of various metals in peripheral blood after long-term frozen storage. The concentrations of 22 metals (Al, As, Ba, Ca, Cd, Cr, Co, Cu, Mn, Mg, Mo, Ni, Fe, Pb, Rb, Se, Sn, Sb, Sr, Ti, V, Zn) in whole blood, blood cells and plasma from 22 healthy participants were determined twice, 18 months apart, using inductively coupled plasma mass spectrometry (ICP-MS). The mean percentage error (MPE) and intraclass correlation coefficient (ICC) were calculated to evaluate the impact of the anticoagulants and long-term frozen storage on metal concentrations, respectively. The concentrations of Sb and Ba in whole blood, blood cells and plasma were significantly altered by EDTA and sodium heparin at two measurement timepoints (P < 0.05 and MPE > 80%). In EDTA tubes, the Ti and Ni concentrations in blood cells were changed significantly; and in heparin tubes, the concentrations of Ni and Mo in blood cells and Sb in plasma were also altered (P < 0.05 and MPE > 80%). The ICCs of 11 metals in whole blood, 15 metals in blood cells and 16 metals in plasma remained unchanged in EDTA tubes, and 16 metals in whole blood, 15 metals in blood cells and 17 metals in plasma remained unchanged in heparin tubes (ICC > 0.40). Our study suggested the use of EDTA tubes to determine Sb concentrations in peripheral blood and heparin tubes to determine Ba concentrations. Additionally, heparin tubes may be more suited for determining multiple metal concentrations in whole blood, whereas for blood cells and plasma either EDTA or heparin tubes could be used.

ACS Style

Yu Bao; Xiaoting Ge; Longman Li; Junxiu He; Sifang Huang; Xiaoyu Luo; Xing Chen; Pan Chen; Xiaobo Yang. The impacts of different anticoagulants and long-term frozen storage on multiple metal concentrations in peripheral blood: a comparative study. BioMetals 2021, 1 -15.

AMA Style

Yu Bao, Xiaoting Ge, Longman Li, Junxiu He, Sifang Huang, Xiaoyu Luo, Xing Chen, Pan Chen, Xiaobo Yang. The impacts of different anticoagulants and long-term frozen storage on multiple metal concentrations in peripheral blood: a comparative study. BioMetals. 2021; ():1-15.

Chicago/Turabian Style

Yu Bao; Xiaoting Ge; Longman Li; Junxiu He; Sifang Huang; Xiaoyu Luo; Xing Chen; Pan Chen; Xiaobo Yang. 2021. "The impacts of different anticoagulants and long-term frozen storage on multiple metal concentrations in peripheral blood: a comparative study." BioMetals , no. : 1-15.

Journal article
Published: 02 July 2021 in Ecotoxicology and Environmental Safety
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Single toxic metal exposure has been reported to be associated with impaired cognitive function, but less is known about the effects of combined exposure to multiple metals. The aim of the study was to investigate the potential associations and interactions of multiple metals with cognitive function in older adults using multi-pollutants approach. A cross-sectional study was conducted in a total of 2879 participants aged ≥ 60 years old. We systematically measured levels of 22 blood metals and used the Mini-Mental State Examination (MMSE) to assess the cognitive function. The least absolute shrinkage and selection operator (LASSO) penalized regression was applied to identify independently main metals. Adjusted estimates of cognitive function with selected metals were investigated by generalized linear regression in the multi-metal model. We found that calcium, titanium, vanadium, copper, zinc, arsenic, selenium, rubidium, molybdenum, cadmium, barium, and lead were independently identified based on LASSO penalized regression. The multi-metal model showed a higher MMSE of 0.384 (95% CI: 0.122–0.646) for a 1-SD increment in log-transformed rubidium and a lower MMSE of 0.460 (95% CI: − 0.706 to − 0.214) for a 1-SD increment in log-transformed cadmium (P < 0.05). The significantly negative associations between cadmium and cognitive function were attenuated to null accompanying with increasing concentrations of rubidium (P interaction = 0.256). Our findings suggested that blood rubidium and cadmium were mainly associated with cognitive function when accounting for co-exposure to other metals and higher level of rubidium appeared to attenuate the toxic effects of cadmium on cognitive function in older adults.

ACS Style

Lili Xiao; Gaohui Zan; Jian Qin; Xiao Wei; Guodong Lu; Xiyi Li; Haiying Zhang; Yunfeng Zou; Li Yang; Min He; Zhiyong Zhang; Xiaobo Yang. Combined exposure to multiple metals and cognitive function in older adults. Ecotoxicology and Environmental Safety 2021, 222, 112465 .

AMA Style

Lili Xiao, Gaohui Zan, Jian Qin, Xiao Wei, Guodong Lu, Xiyi Li, Haiying Zhang, Yunfeng Zou, Li Yang, Min He, Zhiyong Zhang, Xiaobo Yang. Combined exposure to multiple metals and cognitive function in older adults. Ecotoxicology and Environmental Safety. 2021; 222 ():112465.

Chicago/Turabian Style

Lili Xiao; Gaohui Zan; Jian Qin; Xiao Wei; Guodong Lu; Xiyi Li; Haiying Zhang; Yunfeng Zou; Li Yang; Min He; Zhiyong Zhang; Xiaobo Yang. 2021. "Combined exposure to multiple metals and cognitive function in older adults." Ecotoxicology and Environmental Safety 222, no. : 112465.

Review
Published: 17 June 2021 in Toxics
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Metals are actively involved in multiple catalytic physiological activities. However, metal overload may result in neurotoxicity as it increases formation of reactive oxygen species (ROS) and elevates oxidative stress in the nervous system. Mitochondria are a key target of metal-induced toxicity, given their role in energy production. As the brain consumes a large amount of energy, mitochondrial dysfunction and the subsequent decrease in levels of ATP may significantly disrupt brain function, resulting in neuronal cell death and ensuing neurological disorders. Here, we address contemporary studies on metal-induced mitochondrial dysfunction and its impact on the nervous system.

ACS Style

Hong Cheng; Bobo Yang; Tao Ke; Shaojun Li; Xiaobo Yang; Michael Aschner; Pan Chen. Mechanisms of Metal-Induced Mitochondrial Dysfunction in Neurological Disorders. Toxics 2021, 9, 142 .

AMA Style

Hong Cheng, Bobo Yang, Tao Ke, Shaojun Li, Xiaobo Yang, Michael Aschner, Pan Chen. Mechanisms of Metal-Induced Mitochondrial Dysfunction in Neurological Disorders. Toxics. 2021; 9 (6):142.

Chicago/Turabian Style

Hong Cheng; Bobo Yang; Tao Ke; Shaojun Li; Xiaobo Yang; Michael Aschner; Pan Chen. 2021. "Mechanisms of Metal-Induced Mitochondrial Dysfunction in Neurological Disorders." Toxics 9, no. 6: 142.

Article
Published: 27 March 2021 in Biological Trace Element Research
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Manganese (Mn)-induced neurotoxicity has aroused public concerns for many years, but its precise mechanism is still poorly understood. Herein, we report the impacts of the phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) signaling pathway in mediating neurological effects induced by manganese sulfate (MnSO4) exposure in PC12 cells. In this study, cells were treated with MnSO4 for 24 h in the absence or presence of LY294002 (a special inhibitor of PI3K). We investigated cell viability and apoptosis signals, as well as levels of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT), and malondialdehyde (MDA). The mRNA levels of B-cell lymphoma 2 (Bcl-2), Bcl-2-associated X protein (Bax), and Caspase-3 were also quantified through real-time quantitative PCR (RT-qPCR); protein levels of serine/threonine protein kinase (Akt) and forkhead box O3A (Foxo3a) were determined by western blot. Increasing of MnSO4 doses led to decreased SOD, GSH-Px, and CAT activities, while the level of MDA was upregulated. Moreover, cell apoptosis was significantly increased, as the mRNA of Bcl-2 and Caspase-3 was significantly decreased, while Bax mRNA was increased. Phosphorylated Akt (p-Akt) and Foxo3a (p-Foxo3a) were upregulated in a dose-dependent manner. In addition, LY294002 pretreatment reduced the activity of SOD, GSH-Px, and CAT but elevated MDA levels. Meanwhile, LY294002 pretreatment also increased cell apoptosis given the upregulated Bax and Caspase-3 mRNAs and decreased Bcl-2 mRNA. In summary, the PI3K/Akt signaling pathway can be activated by MnSO4 exposure and mediate MnSO4-induced neurotoxicity.

ACS Style

Yanli Tan; Hong Cheng; Cheng Su; Pan Chen; Xiaobo Yang. PI3K/Akt Signaling Pathway Ameliorates Oxidative Stress-Induced Apoptosis upon Manganese Exposure in PC12 Cells. Biological Trace Element Research 2021, 1 -12.

AMA Style

Yanli Tan, Hong Cheng, Cheng Su, Pan Chen, Xiaobo Yang. PI3K/Akt Signaling Pathway Ameliorates Oxidative Stress-Induced Apoptosis upon Manganese Exposure in PC12 Cells. Biological Trace Element Research. 2021; ():1-12.

Chicago/Turabian Style

Yanli Tan; Hong Cheng; Cheng Su; Pan Chen; Xiaobo Yang. 2021. "PI3K/Akt Signaling Pathway Ameliorates Oxidative Stress-Induced Apoptosis upon Manganese Exposure in PC12 Cells." Biological Trace Element Research , no. : 1-12.

Journal article
Published: 19 February 2021 in Environmental Pollution
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Previous studies have reported metals exposure contribute to the change of fasting blood glucose (FBG) level. However, the roles of reproductive hormones in their associations have not been fully elucidated. The aim of the study is to investigate the associations of multiple serum metals with reproductive hormones, and to further explore potential roles of reproductive hormones in relationships between metals exposure and FBG level. A total of 1911 Chinese Han men were analyzed by a cross-sectional study. We measured serum levels of 22 metals by inductively coupled plasma mass spectrometer (ICP-MS). FBG, total testosterone (TT), estradiol (E2), follicle stimulating hormone (FSH), and sex hormone-binding globulin (SHBG) levels were determined. Least absolute shrinkage and selection operator (LASSO) regression models were conducted to select important metals, and restricted cubic spline models were then used to estimate dose-response relationships between selected metals and reproductive hormones. We also conducted mediation analyses to evaluate whether reproductive hormones played mediating roles in the associations between metals and FBG. We found significant inverse dose-dependent trends of copper, tin and zinc with E2; zinc with SHBG; copper and nickel with TT, while significant positive dose-dependent trend of iron with E2, respectively. Moreover, approximately inverted U-shaped associations existed between lead and SHBG, iron and TT. In addition, E2, SHBG and TT were negatively associated with FBG level. In mediation analyses, the association of copper with FBG was mediated by E2 and TT, with a mediation ratio of 10.4% and 22.1%, respectively. Furthermore, E2 and SHBG mediated the relationship of zinc with FBG, with a mediation ratio of 7.8% and 14.5%, respectively. E2 mediated 11.5% of positive relationship between tin with FBG. Our study suggested that the associations of metals exposure with FBG may be mediated by reproductive hormones.

ACS Style

Gaohui Zan; Longman Li; Hong Cheng; Lulu Huang; Sifang Huang; Xiaoyu Luo; Lili Xiao; Chaoqun Liu; Haiying Zhang; Zengnan Mo; Xiaobo Yang. Mediated relationships between multiple metals exposure and fasting blood glucose by reproductive hormones in Chinese men. Environmental Pollution 2021, 278, 116791 .

AMA Style

Gaohui Zan, Longman Li, Hong Cheng, Lulu Huang, Sifang Huang, Xiaoyu Luo, Lili Xiao, Chaoqun Liu, Haiying Zhang, Zengnan Mo, Xiaobo Yang. Mediated relationships between multiple metals exposure and fasting blood glucose by reproductive hormones in Chinese men. Environmental Pollution. 2021; 278 ():116791.

Chicago/Turabian Style

Gaohui Zan; Longman Li; Hong Cheng; Lulu Huang; Sifang Huang; Xiaoyu Luo; Lili Xiao; Chaoqun Liu; Haiying Zhang; Zengnan Mo; Xiaobo Yang. 2021. "Mediated relationships between multiple metals exposure and fasting blood glucose by reproductive hormones in Chinese men." Environmental Pollution 278, no. : 116791.

Preprint content
Published: 09 December 2020
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Backgrounds: The deleterious effects of abdominal obesity and aging have grown into a global health issue. However, relationships between abdominal obesity and renal function with aging and underlying mechanisms have not been fully elucidated. We aimed to explore associations of abdominal obesity with renal function in older individuals and further investigate potential mechanisms of metabolic traits on them. Methods: We conducted a cross-sectional study of 4,086 participants aged 60-115 years. Generalized linear models were used to quantify dose-response relationships of abdominal obesity with metabolic traits and renal function. Mediation analysis was performed to assess mediating effects of metabolic traits in the associations between abdominal obesity and renal function. Results: We found negative dose-response relationships between waist circumstance and the estimated glomerular rate (eGFR) (P P P Conclusion: Our findings suggest individuals of abdominal obesity are more susceptible to the nephrotoxic effect with aging, and highlight the metabolic pathways, especially TG, in the link of abdominal obesity with decreased renal function.

ACS Style

Lili Xiao; Gaohui Zan; Xiaoting Ge; Xiuming Feng; Yu Bao; Xiaobo Yang. The Mediating Effects of Metabolic Traits on the Association between Abdominal Obesity and Renal Function in Older Adults. 2020, 1 .

AMA Style

Lili Xiao, Gaohui Zan, Xiaoting Ge, Xiuming Feng, Yu Bao, Xiaobo Yang. The Mediating Effects of Metabolic Traits on the Association between Abdominal Obesity and Renal Function in Older Adults. . 2020; ():1.

Chicago/Turabian Style

Lili Xiao; Gaohui Zan; Xiaoting Ge; Xiuming Feng; Yu Bao; Xiaobo Yang. 2020. "The Mediating Effects of Metabolic Traits on the Association between Abdominal Obesity and Renal Function in Older Adults." , no. : 1.

Journal article
Published: 05 December 2020 in Environmental Pollution
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Aging is a leading cause of mortality for the elderly and DNA methylation age is reported to be predictive of biological aging. However, few studies have investigated the associations between multiple metals exposure and accelerated aging in the elderly. We performed a pilot study of 288 elderly participants aged 50 to 115 years and measured genome-wide DNA methylation and 22 blood metals concentrations. Measures of DNA methylation age were estimated using CpGs from Illumina HumanMethylation EPIC BeadChip. Linear mixed regression and Bayesian kernel machine regression (BKMR) models were used to estimate the individual and overall associations between multiple metals and accelerated methylation aging. Single metal models revealed that each 1-standard deviance (SD) increase in log-transformed vanadium, cobalt, nickel, zinc, arsenic, and barium was associated with a -2.256, -1.318, 1.004, -1.926, 1.910 and -1.356 changes in ΔAge, respectively; meanwhile, for aging rate, the change was -0.019, -0.013, 0.010, -0.018, 0.023, and -0.012, respectively (all P<0.05). The BKMR models showed reverse U-shaped associations of the overall metals mixture with ΔAge and aging rate. Downward trends of ΔAge and aging rate were observed for increasing quantiles of essential metals mixture, but upward trends were observed for non-essential metals mixture. Further individual analysis of the BKMR revealed that the 95% confidence interval of ΔAge and aging rate associated with vanadium, zinc, and arsenic did not cross 0, when other metals concentrations set at 25th, 50th, and 75th percentile. Our findings suggest reverse U-shaped associations of the overall metals mixture with accelerated methylation aging for the first time, and vanadium, zinc, and arsenic may be major contributors driving the associations.

ACS Style

Lili Xiao; Gaohui Zan; Xiuming Feng; Yu Bao; Sifang Huang; Xiaoyu Luo; Xia Xu; Zhiyong Zhang; Xiaobo Yang. The associations of multiple metals mixture with accelerated DNA methylation aging. Environmental Pollution 2020, 269, 116230 .

AMA Style

Lili Xiao, Gaohui Zan, Xiuming Feng, Yu Bao, Sifang Huang, Xiaoyu Luo, Xia Xu, Zhiyong Zhang, Xiaobo Yang. The associations of multiple metals mixture with accelerated DNA methylation aging. Environmental Pollution. 2020; 269 ():116230.

Chicago/Turabian Style

Lili Xiao; Gaohui Zan; Xiuming Feng; Yu Bao; Sifang Huang; Xiaoyu Luo; Xia Xu; Zhiyong Zhang; Xiaobo Yang. 2020. "The associations of multiple metals mixture with accelerated DNA methylation aging." Environmental Pollution 269, no. : 116230.

Journal article
Published: 03 December 2020 in Science of The Total Environment
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Studies with multi-pollutant approach on the relationships between multiple metals and fasting plasma glucose (FPG) is limited. Few studies are available on the potential sex-specific associations between metal exposures and glucose metabolism. We explored the associations between 22 plasma metals and FPG level among the 769 participants from the manganese-exposed workers healthy cohort in China. We applied a sparse partial least squares (sPLS) regression followed by ordinary least-squares regression to evaluate multi-pollutant association. Bayesian kernel machine regression (BKMR) model was used to deal with metal mixtures and evaluate their joint effects on FPG level. In the sPLS model, negative associations on FPG levels were observed for plasma iron (belta = −0.066), cobalt (belta = −0.075), barium (belta = −0.109), and positive associations for strontium (belta = 0.082), and selenium (belta = 0.057) in men, which overlapped with the results among the overall participants. Among women, plasma copper (belta = 0.112) and antimony (belta = 0.137) were positively associated with elevated FPG level. Plasma magnesium was negatively associated with FPG level in both sexes (belta = −0.071 in men and (belta = −0.144 in women). The results of overlapped for plasma magnesium was selected as the significant contributor to decreasing FPG level in the multi-pollutant, single-metal, and multi-metal models. BKMR model showed a significantly negative over-all effect of six metal mixtures (magnesium, iron, cobalt, selenium, strontium and barium) on FPG level among the overall participants with all the metals fixed at 50th percentile. In summary, our findings underline the probable role of metals in glucose homeostasis with potential sex-dependent heterogeneities, and suggest more researches are needed to explore the sex-specific associations of metal exposures with risk of diabetes.

ACS Style

Xiaoting Ge; Aimin Yang; Sifang Huang; Xiaoyu Luo; Qingzhi Hou; Lulu Huang; Yanting Zhou; Defu Li; Yingnan Lv; Longman Li; Hong Cheng; Xiang Chen; Gaohui Zan; Yanli Tan; Chaoqun Liu; Lili Xiao; Yunfeng Zou; Xiaobo Yang. Sex-specific associations of plasma metals and metal mixtures with glucose metabolism: An occupational population-based study in China. Science of The Total Environment 2020, 760, 143906 .

AMA Style

Xiaoting Ge, Aimin Yang, Sifang Huang, Xiaoyu Luo, Qingzhi Hou, Lulu Huang, Yanting Zhou, Defu Li, Yingnan Lv, Longman Li, Hong Cheng, Xiang Chen, Gaohui Zan, Yanli Tan, Chaoqun Liu, Lili Xiao, Yunfeng Zou, Xiaobo Yang. Sex-specific associations of plasma metals and metal mixtures with glucose metabolism: An occupational population-based study in China. Science of The Total Environment. 2020; 760 ():143906.

Chicago/Turabian Style

Xiaoting Ge; Aimin Yang; Sifang Huang; Xiaoyu Luo; Qingzhi Hou; Lulu Huang; Yanting Zhou; Defu Li; Yingnan Lv; Longman Li; Hong Cheng; Xiang Chen; Gaohui Zan; Yanli Tan; Chaoqun Liu; Lili Xiao; Yunfeng Zou; Xiaobo Yang. 2020. "Sex-specific associations of plasma metals and metal mixtures with glucose metabolism: An occupational population-based study in China." Science of The Total Environment 760, no. : 143906.

Article
Published: 03 October 2020 in Biological Trace Element Research
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Although many studies have confirmed metabolic syndrome (MetS) is correlated with metal exposures, few studies have elucidated the associations of multiple metals with MetS risk. We aim to explore the relationship between serum 22 metals and MetS. We determined serum 22 metals using ICP-MS and used LASSO regression to select metals independently related with MetS to construct multiple-metals model. We further explored the dose-response relationship between positive metals and MetS by the restricted cubic spline regression. After screening by LASSO regression, serum 11 metals were selected to construct multiple-metals model in cross-sectional analysis, while 5 metals in longitudinal analysis. In the 11-metal model, only tin and zinc were associated with MetS in cross-sectional analysis (ORtin = 2.22, 95% CI:1.43, 3.45; ORzinc = 2.17, 95% CI: 1.42, 3.32; both Ptrend < 0.05). Besides, the same results were found in the 5-metal model in longitudinal analysis (HRtin = 1.66, 95% CI: 0.87, 3.17; HRzinc = 1.83, 95% CI: 1.07, 3.14; both Ptrend < 0.05). Moreover, there were positive linear relationships between serum tin and zinc concentrations and the increasing risk of MetS (both Poverall < 0.05, Pnon-linearity > 0.05). Furthermore, the interaction between high tin and high zinc was also associated with increasing MetS risk (Pinteraction < 0.05). We found that serum tin and zinc were independently and interactively associated with MetS in the southern Chinese men. Our results suggested that high tin and zinc may be the risk factors of MetS.

ACS Style

Xiuming Feng; Longman Li; Lulu Huang; Haiying Zhang; Zengnan Mo; Xiaobo Yang. Associations Between Serum Multiple Metals Exposures and Metabolic Syndrome: a Longitudinal Cohort Study. Biological Trace Element Research 2020, 199, 2444 -2455.

AMA Style

Xiuming Feng, Longman Li, Lulu Huang, Haiying Zhang, Zengnan Mo, Xiaobo Yang. Associations Between Serum Multiple Metals Exposures and Metabolic Syndrome: a Longitudinal Cohort Study. Biological Trace Element Research. 2020; 199 (7):2444-2455.

Chicago/Turabian Style

Xiuming Feng; Longman Li; Lulu Huang; Haiying Zhang; Zengnan Mo; Xiaobo Yang. 2020. "Associations Between Serum Multiple Metals Exposures and Metabolic Syndrome: a Longitudinal Cohort Study." Biological Trace Element Research 199, no. 7: 2444-2455.

Journal article
Published: 09 July 2020 in Environment International
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Human are widely exposed to multiple metals, some of which have suspected reproductive toxicity, but no human studies have investigated the developmental effects of prenatal metal exposure. We aimed to evaluate the associations between prenatal multiple metal exposure and reproductive development in boys at 2–3 years using multi-pollutant approach. This prospective study used data of 564 mother–child pairs recruited from the Guangxi Birth Cohort Study. Twenty serum metal concentrations were measured. Least absolute shrinkage and selection operator (LASSO) penalized regression was used to identify independent associations between prenatal multiple metal exposure and testicular volume (TV), and anogenital distance (AGD). Adjusted estimates were then obtained using multiple linear regression analysis, and the regression tree method was used to explore the interactions. Boys in the highest quartile of prenatal lead exposure had a 0.064 mL (95% CI: −0.124, −0.004) smaller ln-transformed TV, 0.060 cm (95% CI: −0.110, −0.011) shorter ln-transformed anopenile distance (AGDap), and 0.115 cm (95% CI: −0.190, −0.039) shorter ln-transformed anoscrotal distance (AGDas) than boys in the lowest quartile (all Ptrend < 0.05). Chromium was inversely with ln-transformed AGDap (β = −0.078, 95% CI: −0.127, −0.030) and ln-transformed AGDas (β = −0.113, 95% CI: −0.188, −0.038), while stibium was positivity associated with ln-transformed AGDap (β = 0.091, 95% CI: 0.046, 0.136) and strontium was positivity associated with ln-transformed AGDas (β = 0.120, 95% CI: 0.051, 0.189) (all Ptrend < 0.05). And the critical window of vulnerability may be the late pregnancy (the second and third trimester). Moreover, we detected interaction effects between lead, chromium and stibium on AGDap; lead, chromium and strontium on AGDas. The results suggest that prenatal exposure to lead, chromium, stibium and strontium may affect TV and/or AGD in infant boys. Potential mechanisms for the complex metal interactive effects during vulnerable periods are worthy of further investigation.

ACS Style

Lulu Huang; Sifang Huang; Xiaoyu Luo; Longman Li; Xiang Chen; Gaohui Zan; Yanli Tan; Chaoqun Liu; Qingzhi Hou; Xiaoting Ge; Chunfei Chen; Xin Hong; Yan Tian; Aimin Yang; Pan Chen; Mujun Li; Zengnan Mo; Xiaobo Yang. Associations of prenatal exposure to multiple metals with testicular volume and anogenital distance in infant boys: A longitudinal cohort study. Environment International 2020, 143, 105900 .

AMA Style

Lulu Huang, Sifang Huang, Xiaoyu Luo, Longman Li, Xiang Chen, Gaohui Zan, Yanli Tan, Chaoqun Liu, Qingzhi Hou, Xiaoting Ge, Chunfei Chen, Xin Hong, Yan Tian, Aimin Yang, Pan Chen, Mujun Li, Zengnan Mo, Xiaobo Yang. Associations of prenatal exposure to multiple metals with testicular volume and anogenital distance in infant boys: A longitudinal cohort study. Environment International. 2020; 143 ():105900.

Chicago/Turabian Style

Lulu Huang; Sifang Huang; Xiaoyu Luo; Longman Li; Xiang Chen; Gaohui Zan; Yanli Tan; Chaoqun Liu; Qingzhi Hou; Xiaoting Ge; Chunfei Chen; Xin Hong; Yan Tian; Aimin Yang; Pan Chen; Mujun Li; Zengnan Mo; Xiaobo Yang. 2020. "Associations of prenatal exposure to multiple metals with testicular volume and anogenital distance in infant boys: A longitudinal cohort study." Environment International 143, no. : 105900.

Journal article
Published: 05 June 2020 in BMC Public Health
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ACS Style

Xiaoyu Luo; Zhenfang Liu; Xiaoting Ge; Sifang Huang; Yanting Zhou; Defu Li; Longman Li; Xiang Chen; Lulu Huang; Qingzhi Hou; Hong Cheng; Lili Xiao; Chaoqun Liu; Yunfeng Zou; Xiaobo Yang. High manganese exposure decreased the risk of high triglycerides in workers: a cross-sectional study. BMC Public Health 2020, 20, 874 .

AMA Style

Xiaoyu Luo, Zhenfang Liu, Xiaoting Ge, Sifang Huang, Yanting Zhou, Defu Li, Longman Li, Xiang Chen, Lulu Huang, Qingzhi Hou, Hong Cheng, Lili Xiao, Chaoqun Liu, Yunfeng Zou, Xiaobo Yang. High manganese exposure decreased the risk of high triglycerides in workers: a cross-sectional study. BMC Public Health. 2020; 20 (1):874.

Chicago/Turabian Style

Xiaoyu Luo; Zhenfang Liu; Xiaoting Ge; Sifang Huang; Yanting Zhou; Defu Li; Longman Li; Xiang Chen; Lulu Huang; Qingzhi Hou; Hong Cheng; Lili Xiao; Chaoqun Liu; Yunfeng Zou; Xiaobo Yang. 2020. "High manganese exposure decreased the risk of high triglycerides in workers: a cross-sectional study." BMC Public Health 20, no. 1: 874.

Journal article
Published: 29 February 2020 in Science of The Total Environment
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The homeostasis imbalance of metals is closely associated with nonalcoholic fatty liver disease (NAFLD). A total of 1594 and 566 Chinese Han men were enrolled in cross-sectional and longitudinal analyses, respectively. We measured the serum concentrations of 22 metals by ICP-MS. The traditional and the LASSO regression methods were used to construct multiple-metals models, respectively. We performed Mendelian randomization (MR) analysis to confirm the causal relationship between NAFLD and metals using three NAFLD-related SNPs as instrumental variable. After adjustment in the six-metal model, only depressed molybdenum and elevated zinc were associated with a higher NAFLD risk, in both cross-sectional and longitudinal analyses. In the twelve-metal model, similar results were still observed. Moreover, dose-response relationships were non-linear for molybdenum and positively linear for zinc with NAFLD risk. In MR analysis, no causal associations were found from NAFLD to molybdenum and zinc. Our results support that serum molybdenum levels were non-linearly associated with NAFLD risk in Chinese men, whereas serum zinc levels showed a positively linear association. Moreover, MR analysis indicated the changes in serum molybdenum and zinc levels might be not caused by NAFLD, further confirmed our findings in cross-sectional and longitudinal analyses.

ACS Style

Longman Li; Lulu Huang; Sifang Huang; Xiaoyu Luo; Haiying Zhang; Zengnan Mo; Tangchun Wu; Xiaobo Yang. Non-linear association of serum molybdenum and linear association of serum zinc with nonalcoholic fatty liver disease: Multiple-exposure and Mendelian randomization approach. Science of The Total Environment 2020, 720, 137655 .

AMA Style

Longman Li, Lulu Huang, Sifang Huang, Xiaoyu Luo, Haiying Zhang, Zengnan Mo, Tangchun Wu, Xiaobo Yang. Non-linear association of serum molybdenum and linear association of serum zinc with nonalcoholic fatty liver disease: Multiple-exposure and Mendelian randomization approach. Science of The Total Environment. 2020; 720 ():137655.

Chicago/Turabian Style

Longman Li; Lulu Huang; Sifang Huang; Xiaoyu Luo; Haiying Zhang; Zengnan Mo; Tangchun Wu; Xiaobo Yang. 2020. "Non-linear association of serum molybdenum and linear association of serum zinc with nonalcoholic fatty liver disease: Multiple-exposure and Mendelian randomization approach." Science of The Total Environment 720, no. : 137655.

Research article
Published: 29 February 2020 in American Journal of Industrial Medicine
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Background Elevated exposure to manganese (Mn) could induce cardiovascular dysfunction. However, limited research is available on the effects of occupational Mn exposure on myocardial enzymes. We aimed to evaluate the relationships between Mn exposure and myocardial enzyme elevation among Mn‐exposed workers. Methods Data were from a follow‐up investigation of a Mn‐exposed workers healthy cohort in 2017. A total of 744 workers were divided into low‐exposure and high‐exposure groups according to Mn time‐weighted average (Mn‐TWA) of less than or equal to 0.15 mg/m3 or greater than 0.15 mg/m3, respectively. Serum levels of myocardial enzymes, including creatine kinase (CK) and creatine kinase‐MB (CK‐MB), lactic dehydrogenase, α‐hydroxybutyrate dehydrogenase, and aspartate transaminase, were assessed, as well as airborne Mn exposure levels. Results After adjustment for sex, body mass index, seniority, education, current smoking status, current drinking status, and hypertension, Mn‐TWA levels were positively associated with the risk of CK elevation (odds ratio [OR] = 1.47 (95% confidence interval [CI]: 1.18‐1.83) per interquartile range [IQR] increase), and risk of CK‐MB elevation [OR = 1.57 (95% CI: 1.03‐2.38) per IQR increase]. In a stratified analysis, Mn‐TWA levels were positively correlated with CK elevation in workers of seniority greater than 19 years, male workers, current smokers, and drinkers. Conclusion Our results suggest that occupational exposure to Mn is associated with increased risk of CK and CK‐MB elevation. The potential mechanisms of the associations between airborne exposure to Mn and increased risk of these myocardial enzyme elevations warrant further investigation.

ACS Style

Sifang Huang; Zhenfang Liu; Xiaoting Ge; Xiaoyu Luo; Yanting Zhou; Defu Li; Longman Li; Xiang Chen; Lulu Huang; Hong Cheng; Qingzhi Hou; Gaohui Zan; Yanli Tan; Chaoqun Liu; Yunfeng Zou; Xiaobo Yang. Occupational exposure to manganese and risk of creatine kinase and creatine kinase‐MB elevation among ferromanganese refinery workers. American Journal of Industrial Medicine 2020, 63, 394 -401.

AMA Style

Sifang Huang, Zhenfang Liu, Xiaoting Ge, Xiaoyu Luo, Yanting Zhou, Defu Li, Longman Li, Xiang Chen, Lulu Huang, Hong Cheng, Qingzhi Hou, Gaohui Zan, Yanli Tan, Chaoqun Liu, Yunfeng Zou, Xiaobo Yang. Occupational exposure to manganese and risk of creatine kinase and creatine kinase‐MB elevation among ferromanganese refinery workers. American Journal of Industrial Medicine. 2020; 63 (5):394-401.

Chicago/Turabian Style

Sifang Huang; Zhenfang Liu; Xiaoting Ge; Xiaoyu Luo; Yanting Zhou; Defu Li; Longman Li; Xiang Chen; Lulu Huang; Hong Cheng; Qingzhi Hou; Gaohui Zan; Yanli Tan; Chaoqun Liu; Yunfeng Zou; Xiaobo Yang. 2020. "Occupational exposure to manganese and risk of creatine kinase and creatine kinase‐MB elevation among ferromanganese refinery workers." American Journal of Industrial Medicine 63, no. 5: 394-401.

Journal article
Published: 27 February 2020 in BMC Pregnancy and Childbirth
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Background Currently, there are many studies researched the associations between maternal serum inflammatory indicators (i.e. ferritin, C-reactive protein [CRP], C3 and C4) and preterm birth (PTB). The results, however, are inconsistent. Therefore, the aim of this study was to estimate the relationship between maternal serum inflammatory indicators and PTB in a nested case-control (NCC)study. Methods A NCC study was conducted by Guangxi Birth Cohort Study which enrolled a total of 6203 pregnant women between 50/7 and 346/7 weeks of gestational age (wGA) from six cities in China between 2015 and 2016. There were 206women who delivered preterm (< 370/7 wGA), and 412 women who delivered term birth, those women were matched by maternal age, birth place, gender of infants, and wGA at blood collection. The inflammatory indicators were quantified by immunoturbidimetric methods. Results Highest quartile concentrations of all inflammatory indicators were determined versus median. After adjusting for maternal age, high levels of CRP (CRP > 16.60 mg/L) are related to the risk of PTB (OR = 2.16, 95% CI: 1.02–4.56, p = 0.044) in the first trimester. The association of C3 was extremely related to those who delivered PTB (OR = 2.53, 95% CI: 1.14–5.64, p = 0.023) in the first trimester. Moreover, no significant associations were found in C4 (p = 0.079) and ferritin (p = 0.067) between PTB. Conclusions Elevated concentrations of CRP and C3 in the first trimester were associated with increased risk of PTB. Inflammatory indicators may act a pivotal part in early diagnosis and prognosis of PTB.

ACS Style

Shengzhu Huang; Jiarong Tian; Chaoqun Liu; Yu Long; Dehao Cao; Luyun Wei; Xiujuan Zhu; Ruiqiang Tang; Weiwu Liu; Dingyuan Zeng; Mujun Li; Xiaobo Yang; Zengnan Mo. Elevated C-reactive protein and complement C3 levels are associated with preterm birth: a nested case–control study in Chinese women. BMC Pregnancy and Childbirth 2020, 20, 1 -9.

AMA Style

Shengzhu Huang, Jiarong Tian, Chaoqun Liu, Yu Long, Dehao Cao, Luyun Wei, Xiujuan Zhu, Ruiqiang Tang, Weiwu Liu, Dingyuan Zeng, Mujun Li, Xiaobo Yang, Zengnan Mo. Elevated C-reactive protein and complement C3 levels are associated with preterm birth: a nested case–control study in Chinese women. BMC Pregnancy and Childbirth. 2020; 20 (1):1-9.

Chicago/Turabian Style

Shengzhu Huang; Jiarong Tian; Chaoqun Liu; Yu Long; Dehao Cao; Luyun Wei; Xiujuan Zhu; Ruiqiang Tang; Weiwu Liu; Dingyuan Zeng; Mujun Li; Xiaobo Yang; Zengnan Mo. 2020. "Elevated C-reactive protein and complement C3 levels are associated with preterm birth: a nested case–control study in Chinese women." BMC Pregnancy and Childbirth 20, no. 1: 1-9.

Journal article
Published: 10 January 2020 in Journal of Trace Elements in Medicine and Biology
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Manganese (Mn) ions play a crucial role in the immune response. The immunotoxicity of Mn is rarely reported compared with the neurotoxicity of Mn. The purpose of this study was to investigate the associations between chronic Mn exposure and immunological parameters in occupational Mn-exposed workers. A total of 538 workers were selected from the follow-up of manganese-exposed workers healthy cohort (MEWHC) in 2017. We divided the workers into the low-exposure group and the high-exposure group by the cutoff of the manganese-time weighted average (Mn-TWA) setting at 0.15 mg/m3. We examined serum immunological parameters by the immunoturbidimetric method and leukocyte counts and ratios in blood routine. Then we used the generalized linear model analyses and spline analyses to explore the associations between external exposure of Mn and multiple immunological parameters adjusted for variables. Based on the epidemiological analyses, we used Elisa (enzyme-linked immune sorbent assay) to detect plasma complement C3 of Mn-exposed rats. In male workers, the mean value of complement C3 was 1.20 ± 0.16 g/L in the high-exposure group, which was significantly lower as compared to the low-exposure group (1.25 ± 0.18 g/L, P = 0.023). The generalize linear models’ analyses showed that complement C3 value had a significantly negative association with external exposure of Mn included adjustment for variables (β = -0.04, P = 0.035). Moreover, in male rats, the high-exposure group also had a lower level of complement C3 compared with the low-exposure group (P < 0.001). None significant association was observed in immunological parameters among female workers and rats (all P > 0.05). Mn exposure from inhalable dust was associated with decreased complement C3 among occupationally Mn-exposed male individuals but not in female workers, which was further confirmed by the rat model. Further research into the possible mechanism of C3 reduction is needed in the future.

ACS Style

Xiang Chen; Zhenfang Liu; Xiaoting Ge; Xiaoyu Luo; Sifang Huang; Yanting Zhou; Defu Li; Hong Cheng; Longman Li; Lulu Huang; Qingzhi Hou; Gaohui Zan; Yanli Tan; Chaoqun Liu; Yunfeng Zou; Xiaobo Yang. Associations between manganese exposure and multiple immunological parameters in manganese-exposed workers healthy cohort. Journal of Trace Elements in Medicine and Biology 2020, 59, 126454 .

AMA Style

Xiang Chen, Zhenfang Liu, Xiaoting Ge, Xiaoyu Luo, Sifang Huang, Yanting Zhou, Defu Li, Hong Cheng, Longman Li, Lulu Huang, Qingzhi Hou, Gaohui Zan, Yanli Tan, Chaoqun Liu, Yunfeng Zou, Xiaobo Yang. Associations between manganese exposure and multiple immunological parameters in manganese-exposed workers healthy cohort. Journal of Trace Elements in Medicine and Biology. 2020; 59 ():126454.

Chicago/Turabian Style

Xiang Chen; Zhenfang Liu; Xiaoting Ge; Xiaoyu Luo; Sifang Huang; Yanting Zhou; Defu Li; Hong Cheng; Longman Li; Lulu Huang; Qingzhi Hou; Gaohui Zan; Yanli Tan; Chaoqun Liu; Yunfeng Zou; Xiaobo Yang. 2020. "Associations between manganese exposure and multiple immunological parameters in manganese-exposed workers healthy cohort." Journal of Trace Elements in Medicine and Biology 59, no. : 126454.

Journal article
Published: 04 December 2019 in Environmental Pollution
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Few studies specifically address the possible associations between multiple-metal exposures and liver damage among the occupational population. This study aimed to explore the cross-sectional relationships of plasma metals with liver function parameters. For 571 on-the-spot workers in the manganese-exposed workers healthy cohort (MEWHC), we determined liver function parameters: total bilirubin (TBILI), direct bilirubin (DBILI), indirect bilirubin (IBILI), alanine transaminase (ALT) and aspartate transaminase (AST). Total concentrations of 22 plasma metals were measured by ICP-MS. The LASSO (least absolute shrinkage and selection operator) penalized regression model was applied for selecting plasma metals independently associated with liver function parameters. Multiple linear regression analyses and restricted cubic spline (RCS) were utilized for identifying the exposure-response relationship of plasma metals with liver function parameters. After adjusting for covariates and selected metals, a 1-SD increase in log-10 transformed levels of iron was associated with increases in the levels of TBILI, DBILI and IBILI by 20.3%, 12.1% and 23.7%, respectively; similar increases in molybdenum for decreases in levels of TBILI, DBILI and IBILI by 6.1%, 2.6% and 8.3%, respectively. The effect of a 1-SD increase in plasma copper corresponded decreases of 3.2%, 3.4% and 5.0% in TBILI, AST and ALT levels, respectively. The spline analyses further clarified the non-linear relationships between plasma iron and bilirubin whilst negative linear relationships for plasma molybdenum and bilirubin. Plasma iron was positively whilst plasma molybdenum was negatively associated with increased serum bilirubin levels. Further studies are needed to validate these associations and uncover the underlying mechanisms.

ACS Style

Xiaoting Ge; Zhenfang Liu; Qingzhi Hou; Lulu Huang; Yanting Zhou; Defu Li; Sifang Huang; Xiaoyu Luo; Yingnan Lv; Longman Li; Hong Cheng; Xiang Chen; Gaohui Zan; Yanli Tan; Chaoqun Liu; Yunfeng Zou; Xiaobo Yang. Plasma metals and serum bilirubin levels in workers from manganese-exposed workers healthy cohort (MEWHC). Environmental Pollution 2019, 258, 113683 .

AMA Style

Xiaoting Ge, Zhenfang Liu, Qingzhi Hou, Lulu Huang, Yanting Zhou, Defu Li, Sifang Huang, Xiaoyu Luo, Yingnan Lv, Longman Li, Hong Cheng, Xiang Chen, Gaohui Zan, Yanli Tan, Chaoqun Liu, Yunfeng Zou, Xiaobo Yang. Plasma metals and serum bilirubin levels in workers from manganese-exposed workers healthy cohort (MEWHC). Environmental Pollution. 2019; 258 ():113683.

Chicago/Turabian Style

Xiaoting Ge; Zhenfang Liu; Qingzhi Hou; Lulu Huang; Yanting Zhou; Defu Li; Sifang Huang; Xiaoyu Luo; Yingnan Lv; Longman Li; Hong Cheng; Xiang Chen; Gaohui Zan; Yanli Tan; Chaoqun Liu; Yunfeng Zou; Xiaobo Yang. 2019. "Plasma metals and serum bilirubin levels in workers from manganese-exposed workers healthy cohort (MEWHC)." Environmental Pollution 258, no. : 113683.

Research article
Published: 03 December 2019 in Environmental Science and Pollution Research
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Despite well documents for manganese-induced neurological deficits, limited researches are available for effects of manganese (Mn) exposure on the bone. Here we aimed to explore the associations between long-term occupational Mn exposure and bone quality among retired workers. We conducted a cross-sectional study of 304 exposed subjects (n, male = 161 and female = 143) and 277 control retired workers (n, male = 65 and female = 212) recruited from a ferromanganese refinery. Self-reported occupation types were used as exposure classification confirmed by expert consultation. Bone quality was measured by quantitative ultrasound (QUS). In sex-stratified analyses throughout, stiffness index (SI) and T-score levels of the participants in the highest exposed group [tertile 3 of Mn cumulative exposure index (Mn-CEI)] were significantly lower as compared with the control group among female workers (SI, mean, 61.60 vs. 68.17; T-score, mean, −3.01 vs. −2.34, both P < 0.05). In addition, SI and T-score were found to be negatively associated with Mn-CEI only in the highest exposure group as compared with the female controls (both P = 0.01). However, we did not find the significant difference for SI or T-score among the male subjects in exposure models and the male controls (P > 0.05). Our results suggest that female retired workers in the highest Mn-exposed model (tertile 3 of Mn-CEI) potentially experience a higher risk of developing osteoporosis compared with the female controls. Further investigations on possible mechanisms on bone quality alteration are needed in the future.

ACS Style

Defu Li; Xiaoting Ge; Zhenfang Liu; Lulu Huang; Yanting Zhou; Peng Liu; Lian Qin; Suzhen Lin; Chaoqun Liu; Qingzhi Hou; Longman Li; Hong Cheng; Songfeng Ou; Fu Wei; Yuefei Shen; Yunfeng Zou; Xiaobo Yang. Association between long-term occupational manganese exposure and bone quality among retired workers. Environmental Science and Pollution Research 2019, 27, 482 -489.

AMA Style

Defu Li, Xiaoting Ge, Zhenfang Liu, Lulu Huang, Yanting Zhou, Peng Liu, Lian Qin, Suzhen Lin, Chaoqun Liu, Qingzhi Hou, Longman Li, Hong Cheng, Songfeng Ou, Fu Wei, Yuefei Shen, Yunfeng Zou, Xiaobo Yang. Association between long-term occupational manganese exposure and bone quality among retired workers. Environmental Science and Pollution Research. 2019; 27 (1):482-489.

Chicago/Turabian Style

Defu Li; Xiaoting Ge; Zhenfang Liu; Lulu Huang; Yanting Zhou; Peng Liu; Lian Qin; Suzhen Lin; Chaoqun Liu; Qingzhi Hou; Longman Li; Hong Cheng; Songfeng Ou; Fu Wei; Yuefei Shen; Yunfeng Zou; Xiaobo Yang. 2019. "Association between long-term occupational manganese exposure and bone quality among retired workers." Environmental Science and Pollution Research 27, no. 1: 482-489.

Journal article
Published: 30 October 2019 in Food and Chemical Toxicology
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Manganese (Mn), an essential micronutrient, has the potential to induce apoptosis. The NT3/TrkC ligand/receptor pair known as part of the classic neurotrophic theory plays a critical role in neuronal survival. However, whether the NT3/TrkC-mediated signaling pathways are involved in Mn-induced apoptosis of cortical neurons remains unknown. The present study was designed to investigate the interactions between NT3/TrkC-mediated signaling pathways and Mn-induced apoptosis in cortical neurons. This study showed that subacute Mn exposure significantly increased the levels of pro-apoptotic Bax while decreasing the levels of anti-apoptotic Bcl 2 in the cortex compared with the corresponding control. Markedly reduced NT3 and TrkC levels along with decreased Ras/MAPK and PI3/Akt signaling in the cortex were observed following subacute Mn exposure. We further found increased levels of Bax, cleaved caspase-3, and the total apoptosis rate, and decreased levels of Bcl 2, NT3, TrkC, and Ras/MAPK and PI3/Akt signaling in Mn-treated primary cortical neurons. Pretreatment with hNT3 or Z-VAD-FAM ameliorated Mn-induced apoptosis by increasing the levels of NT3 and TrkC and its Ras/MAPK and PI3/Akt signaling pathways. Taken together, our findings clearly indicate that NT3/TrkC and mediated Ras/MAPK and PI3/Akt signaling pathways play a crucial role in Mn-induced neurotoxicity.

ACS Style

Yiping Yang; Fu Wei; Jian Wang; Rui Chen; Jie Zhang; Danni Li; Dong Gan; Xiaobo Yang; Yunfeng Zou. Manganese modifies Neurotrophin-3 (NT3) and its tropomyosin receptor kinase C (TrkC) in the cortex: Implications for manganese-induced neurotoxicity. Food and Chemical Toxicology 2019, 135, 110925 .

AMA Style

Yiping Yang, Fu Wei, Jian Wang, Rui Chen, Jie Zhang, Danni Li, Dong Gan, Xiaobo Yang, Yunfeng Zou. Manganese modifies Neurotrophin-3 (NT3) and its tropomyosin receptor kinase C (TrkC) in the cortex: Implications for manganese-induced neurotoxicity. Food and Chemical Toxicology. 2019; 135 ():110925.

Chicago/Turabian Style

Yiping Yang; Fu Wei; Jian Wang; Rui Chen; Jie Zhang; Danni Li; Dong Gan; Xiaobo Yang; Yunfeng Zou. 2019. "Manganese modifies Neurotrophin-3 (NT3) and its tropomyosin receptor kinase C (TrkC) in the cortex: Implications for manganese-induced neurotoxicity." Food and Chemical Toxicology 135, no. : 110925.

Journal article
Published: 05 August 2019 in The American Journal of Clinical Nutrition
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Background Observational studies present conflicting results about a possible association of iron status with asthma risk, pointing to potential modifiable targets for prevention. Objective The aim of this study was to use Mendelian randomization (MR) to estimate associations between iron status and asthma risk. Methods We used the Genetics of Iron Status consortium to identify genetic variants that could be used as instrumental variables for the effect of systemic iron status. The following sets of instruments were used: a conservative set (instruments restricted to variants with concordant relations to 4 iron status biomarkers) and a liberal set (instruments selected using variants associated with at least 1 of 4 iron status biomarkers). Associations of these genetic variants with asthma risk were estimated in data from the Trans-National Asthma Genetics Consortium (TAGC) and the GABRIEL consortium (A Multidisciplinary Study to Identify the Genetic and Environmental Causes of Asthma in the European Community). Data on the association of genetic variants with iron status and with asthma were combined to assess the influence of iron status on asthma risk. Results In the conservative approach, the MR OR of asthma was 1.00 (95% CI: 0.91, 1.10) per SD increase in iron, 0.96 (95% CI: 0.78, 1.18) in log-transformed ferritin, 0.99 (95% CI: 0.93, 1.06) in transferrin saturation, and 1.03 (95% CI: 0.93, 1.14) in transferrin in the TAGC dataset (none of the values were statistically significant). An age at onset–stratified analysis in the GABRIEL dataset suggested no effect of iron status in childhood onset, later onset, or unknown age at onset asthma. Findings from the liberal approach were similar, and the results persisted in sensitivity analyses (all P > 0.05). Conclusions This MR study does not provide evidence of an effect of iron status on asthma, suggesting that efforts to change iron concentrations will probably not result in decreased risk of asthma.

ACS Style

Lulu Huang; Longman Li; Xiaoyu Luo; Sifang Huang; Qingzhi Hou; Xiaoting Ge; Yingnan Lv; Zengnan Mo; Xiaobo Yang. The association between serum iron status and risk of asthma: a 2-sample Mendelian randomization study in descendants of Europeans. The American Journal of Clinical Nutrition 2019, 110, 959 -968.

AMA Style

Lulu Huang, Longman Li, Xiaoyu Luo, Sifang Huang, Qingzhi Hou, Xiaoting Ge, Yingnan Lv, Zengnan Mo, Xiaobo Yang. The association between serum iron status and risk of asthma: a 2-sample Mendelian randomization study in descendants of Europeans. The American Journal of Clinical Nutrition. 2019; 110 (4):959-968.

Chicago/Turabian Style

Lulu Huang; Longman Li; Xiaoyu Luo; Sifang Huang; Qingzhi Hou; Xiaoting Ge; Yingnan Lv; Zengnan Mo; Xiaobo Yang. 2019. "The association between serum iron status and risk of asthma: a 2-sample Mendelian randomization study in descendants of Europeans." The American Journal of Clinical Nutrition 110, no. 4: 959-968.

Journal article
Published: 16 May 2019 in Chemosphere
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To investigate the associations between prenatal exposure to single metal and multiple metals and the risk of low birth weight (LBW), we conducted a nested case-control study of 246 LBW and 492 normal birth weight (NBW) mother-infant pairs based on a prospective birth cohort study. As sample deficiency, there were 246 LBW and 406 NBW mother-infant pairs in our study. 22 serum metals were detected by inductively coupled plasma quadruple mass spectrometry (ICP-MS). Categorical analyses showed serum Co and Ti were associated with LBW (Co: 3rd vs 4th. quartile: OR = 1.83, 95%CI: 1.14–2.92, P trend = 0.043; Ti: 2nd vs. 4th quartile: OR = 0.51, 95% CI: 0.32–0.81), especially gestational age >13 weeks. Cubic spline analyses showed serum Co and serum Ti had non-linearity associations with LBW (Co: P for overall = 0.048, P-nonlinearity = 0.014; Ti: P for overall = 0.015, P- nonlinearity = 0.008). In multi-metal compound exposure model, 15 metals selected by elastic net model were significantly associated with the increased risk of LBW and OR (95%CI) was 5.14 (2.81, 9.40). Our study suggested that lower level serum Co were positively associated with LBW and lower level serum Ti were negatively associated with LBW, especially gestational age >13 weeks, and both of them had non-linearity dose-relationships with LBW. And multi-metal compound model was significantly associated with LBW compared with single metal model.

ACS Style

Qingzhi Hou; Lulu Huang; Xiaoting Ge; Aimin Yang; Xiaoyu Luo; Sifang Huang; Yang Xiao; Chao Jiang; Longman Li; Zhijian Pan; Tao Teng; Haiying Zhang; Mujun Li; Zengnan Mo; Xiaobo Yang. Associations between multiple serum metal exposures and low birth weight infants in Chinese pregnant women: A nested case-control study. Chemosphere 2019, 231, 225 -232.

AMA Style

Qingzhi Hou, Lulu Huang, Xiaoting Ge, Aimin Yang, Xiaoyu Luo, Sifang Huang, Yang Xiao, Chao Jiang, Longman Li, Zhijian Pan, Tao Teng, Haiying Zhang, Mujun Li, Zengnan Mo, Xiaobo Yang. Associations between multiple serum metal exposures and low birth weight infants in Chinese pregnant women: A nested case-control study. Chemosphere. 2019; 231 ():225-232.

Chicago/Turabian Style

Qingzhi Hou; Lulu Huang; Xiaoting Ge; Aimin Yang; Xiaoyu Luo; Sifang Huang; Yang Xiao; Chao Jiang; Longman Li; Zhijian Pan; Tao Teng; Haiying Zhang; Mujun Li; Zengnan Mo; Xiaobo Yang. 2019. "Associations between multiple serum metal exposures and low birth weight infants in Chinese pregnant women: A nested case-control study." Chemosphere 231, no. : 225-232.